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Schizophrenia-like symptoms in a patient with Leigh syndrome.

Abstract Leigh syndrome is a mitochondrial disease characterized by subacute necrotizing encephalomyelopathy. Almost all cases of Leigh syndrome develop at infancy or early childhood and die within several years due to rapidly progressive muscle weakness and respiratory failure. Here, we present a rare case of a patient who developed Leigh syndrome associated with thiamine-responsive pyruvate dehydrogenase-complex deficiency at 2 years of age and has survived to adolescence through effective high dose thiamin therapy. At 15 years of age, the patient presented persecutory delusions and auditory hallucinations, suggesting an association between mitochondrial dysfunction and schizophrenia-like psychotic symptoms.
PMID
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Authors

Mayor MeshTerms
Keywords

Leigh syndrome

Mitochondrial disease

Schizophrenia-like psychotic symptoms

Journal Title asian journal of psychiatry
Publication Year Start




PMID- 28262162
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170314
LR  - 20170314
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 25
DP  - 2017 Feb
TI  - Schizophrenia-like symptoms in a patient with Leigh syndrome.
PG  - 249-250
LID - S1876-2018(16)30559-7 [pii]
LID - 10.1016/j.ajp.2016.12.012 [doi]
AB  - Leigh syndrome is a mitochondrial disease characterized by subacute necrotizing
      encephalomyelopathy. Almost all cases of Leigh syndrome develop at infancy or
      early childhood and die within several years due to rapidly progressive muscle
      weakness and respiratory failure. Here, we present a rare case of a patient who
      developed Leigh syndrome associated with thiamine-responsive pyruvate
      dehydrogenase-complex deficiency at 2 years of age and has survived to
      adolescence through effective high dose thiamin therapy. At 15 years of age, the 
      patient presented persecutory delusions and auditory hallucinations, suggesting
      an association between mitochondrial dysfunction and schizophrenia-like psychotic
      symptoms.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - Satogami, Kazumi
AU  - Satogami K
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera,
      Wakayama, Japan. Electronic address: kazumi.s@wakayama-med.ac.jp.
FAU - Takahashi, Shun
AU  - Takahashi S
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera,
      Wakayama, Japan.
FAU - Kose, Asami
AU  - Kose A
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera,
      Wakayama, Japan; Department of Psychiatry, Wakayama Prefectural Mental Health
      Care Center, 31 Sho, Aridagawa Town, Arida-Gun, Wakayama, Japan.
FAU - Shinosaki, Kazuhiro
AU  - Shinosaki K
AD  - Department of Neuropsychiatry, Wakayama Medical University, 811-1 Kimiidera,
      Wakayama, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161224
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Leigh Disease/*complications
MH  - Male
MH  - Psychotic Disorders/*etiology
MH  - Schizophrenia/etiology
OTO - NOTNLM
OT  - *Leigh syndrome
OT  - *Mitochondrial disease
OT  - *Schizophrenia-like psychotic symptoms
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/11/29 [received]
PHST- 2016/12/23 [accepted]
AID - S1876-2018(16)30559-7 [pii]
AID - 10.1016/j.ajp.2016.12.012 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2017 Feb;25:249-250. doi: 10.1016/j.ajp.2016.12.012. Epub 2016
      Dec 24.

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