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Neurobehavioral Deficits in Progressive Experimental Hydrocephalus in Neonatal Rats.

Abstract Hydrocephalus is usually associated with functional deficits which can be assessed by neurobehavioral tests. This study characterizes the neurobehavioral deficits occurring with increasing duration and severity of ventriculomegaly in an experimental neonatal hydrocephalic rat model. Hydrocephalus was induced in three weeks old albino rats by intracisternal injection of kaolin while controls received sterile water injection. They were sacrificed in batches at one, four and eight weeks post-injection after neurobehavioral tests (forelimb grip strength, open field and Morris water maze tests) were performed. The hydrocephalic rats were also categorized into mild, moderate and severe hydrocephalus based on ventricular size. The indices of muscular strength and vertical movements in severely hydrocephalic rats were 28.05 ± 5.19 seconds and 7.29 ± 2.71 rearings respectively, compared to controls (75.68 ± 8.58 seconds and 17.09 ± 1.25 rearings respectively). At eight weeks, vertical movements were significantly reduced in hydrocephalic rats compared to controls (3.14 ± 1.3 vs 13 ± 4.11 rearings). At one week, indices of learning and memory were significantly reduced in hydrocephalic rats, compared to controls (0.89±0.31 vs 3.88±1.01 crossings), but at 8 weeks, the indices were similar (2.56 ± 0.41 vs 3.33 ± 0.71 crossings). Untreated hydrocephalus is accompanied by decline in motor functions which increase with duration and severity of ventriculomegaly. However, cognitive deficits appear to partially recover.
PMID
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Authors

Mayor MeshTerms

Behavior, Animal

Keywords
Journal Title nigerian journal of physiological sciences : official publication of the physiological society of nigeria
Publication Year Start




PMID- 28262845
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170315
LR  - 20170315
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar 06
TI  - Neurobehavioral Deficits in Progressive Experimental Hydrocephalus in Neonatal
      Rats.
PG  - 105-113
AB  - Hydrocephalus is usually associated with functional deficits which can be
      assessed by neurobehavioral tests. This study characterizes the neurobehavioral
      deficits occurring with increasing duration and severity of ventriculomegaly in
      an experimental neonatal hydrocephalic rat model. Hydrocephalus was induced in
      three weeks old albino rats by intracisternal injection of kaolin while controls 
      received sterile water injection. They were sacrificed in batches at one, four
      and eight weeks post-injection after neurobehavioral tests (forelimb grip
      strength, open field and Morris water maze tests) were performed. The
      hydrocephalic rats were also categorized into mild, moderate and severe
      hydrocephalus based on ventricular size. The indices of muscular strength and
      vertical movements in severely hydrocephalic rats were 28.05 +/- 5.19 seconds and
      7.29 +/- 2.71 rearings respectively, compared to controls (75.68 +/- 8.58 seconds
      and 17.09 +/- 1.25 rearings respectively). At eight weeks, vertical movements
      were significantly reduced in hydrocephalic rats compared to controls (3.14 +/-
      1.3 vs 13 +/- 4.11 rearings). At one week, indices of learning and memory were
      significantly reduced in hydrocephalic rats, compared to controls (0.89+/-0.31 vs
      3.88+/-1.01 crossings), but at 8 weeks, the indices were similar (2.56 +/- 0.41
      vs 3.33 +/- 0.71 crossings). Untreated hydrocephalus is accompanied by decline in
      motor functions which increase with duration and severity of ventriculomegaly.
      However, cognitive deficits appear to partially recover.
FAU - Olopade, F E
AU  - Olopade FE
AD  - Department of Anatomy, College of Medicine, University of Ibadan.
      [email protected]
FAU - Shokunbi, M T
AU  - Shokunbi MT
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the
      Physiological Society of Nigeria
JID - 8811109
RN  - 24H4NWX5CO (Kaolin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Behavior, Animal
MH  - Cognition
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Female
MH  - Hydrocephalus/chemically induced/*physiopathology/*psychology
MH  - Kaolin
MH  - Male
MH  - Maze Learning
MH  - Memory
MH  - Motor Activity
MH  - Muscle Strength
MH  - Nervous System/*physiopathology
MH  - Rats, Wistar
MH  - Recovery of Function
MH  - Severity of Illness Index
MH  - Time Factors
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO  - Niger J Physiol Sci. 2017 Mar 6;31(2):105-113.

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