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Effects of Selenium Yeast on Blood Glucose and Antioxidant Biomarkers in Cholesterol Fed Diet Induced Type 2 Diabetes Mellitus in Wistar Rats.

Abstract Selenium is an antioxidant that prevents oxygen radical from damaging cells from chronic diseases that can develop from cell injury and inflammation such as diabetes mellitus. The aim of the study is to investigate the possible protective effect of selenium yeast on cholesterol diet induced type-2 diabetes mellitus and oxidative stress in rats. Twenty male wistar rats were divided in to four groups of five animals each: Group 1: (Negative control) received standard animal feed only, Group 2:  received cholesterol diet (CD) only, Group 3: received CD and 0.1 mg/kg selenium yeast orally, Group 4: Received CD and 0.2 mg/kg selenium yeast orally for six weeks. At the end of the study period, the animals were sacrificed and the serum samples were collected and evaluated for estimation of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). The results showed a significant decrease in blood glucose level in the groups  co-administered CD and selenium yeast when compared to CD group only. Antioxidant enzymes status recorded significant decrease in SOD, CAT and GPx activities in CD and selenium yeast administered when compared to CD group only. In Conclusion, Selenium yeast administrations prevent free radical formations which are potent inducer of diabetes mellitus.
PMID
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Authors

Mayor MeshTerms

Cholesterol, Dietary

Diet, High-Fat

Oxidative Stress

Keywords
Journal Title nigerian journal of physiological sciences : official publication of the physiological society of nigeria
Publication Year Start




PMID- 28262851
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170315
LR  - 20170315
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar 06
TI  - Effects of Selenium Yeast on Blood Glucose and Antioxidant Biomarkers in
      Cholesterol Fed Diet Induced Type 2 Diabetes Mellitus in Wistar Rats.
PG  - 147-152
AB  - Selenium is an antioxidant that prevents oxygen radical from damaging cells from 
      chronic diseases that can develop from cell injury and inflammation such as
      diabetes mellitus. The aim of the study is to investigate the possible protective
      effect of selenium yeast on cholesterol diet induced type-2 diabetes mellitus and
      oxidative stress in rats. Twenty male wistar rats were divided in to four groups 
      of five animals each: Group 1: (Negative control) received standard animal feed
      only, Group 2: received cholesterol diet (CD) only, Group 3: received CD and 0.1 
      mg/kg selenium yeast orally, Group 4: Received CD and 0.2 mg/kg selenium yeast
      orally for six weeks. At the end of the study period, the animals were sacrificed
      and the serum samples were collected and evaluated for estimation of antioxidant 
      enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione
      peroxidase (GPx). The results showed a significant decrease in blood glucose
      level in the groups co-administered CD and selenium yeast when compared to CD
      group only. Antioxidant enzymes status recorded significant decrease in SOD, CAT 
      and GPx activities in CD and selenium yeast administered when compared to CD
      group only. In Conclusion, Selenium yeast administrations prevent free radical
      formations which are potent inducer of diabetes mellitus.
FAU - Tanko, Y
AU  - Tanko Y
AD  - Department of Human Physiology, Ahmadu Bello University, Zaria.
      [email protected]
FAU - Jimoh, A
AU  - Jimoh A
FAU - Ahmed, A
AU  - Ahmed A
FAU - Adam, A
AU  - Adam A
FAU - Ejeh, L
AU  - Ejeh L
FAU - Mohammed, A
AU  - Mohammed A
FAU - Ayo, J O
AU  - Ayo JO
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, Dietary)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Catalase/blood
MH  - *Cholesterol, Dietary
MH  - Diabetes Mellitus, Type 2/blood/etiology/*prevention & control
MH  - *Diet, High-Fat
MH  - Disease Models, Animal
MH  - Female
MH  - Glutathione Peroxidase/blood
MH  - Male
MH  - *Oxidative Stress
MH  - Rats, Wistar
MH  - Saccharomyces cerevisiae/*metabolism
MH  - Selenium/*metabolism
MH  - Superoxide Dismutase/blood
MH  - Time Factors
MH  - Yeast, Dried/*metabolism
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO  - Niger J Physiol Sci. 2017 Mar 6;31(2):147-152.

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