PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride.

Abstract Lead (Pb) is cheap and there is a long tradition of its use, but its toxic effects have also been recognized. There is increased public health concern regarding the hazards of low dose Pb exposure to adults and children. Studies have shown the risks for hypertension, decrements in renal function, subtle decline in cognitive function, and adverse reproductive outcome at low blood Pb level. In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated. Twenty adult Wistar rats of both sexes (weight 150g to 200g) were used. The animals were divided into four groups (n = 5) and administered Pb (5mg/kg), Pb (5mg/kg) + CoCl2 (50mg/kg) and CoCl2 (50mg/kg) orally for twenty-eight days. The last group served as control and were given distilled water only. In the tail immersion test, there was no significant change in reaction time for all three groups when compared to the control. In the formalin-induced pain, pain score after five and forty-five minutes also do not show significant change for all the three groups when compared to control. This work suggested that exposure to 5mg/kg Pb for twenty-eight days do not significantly impair reaction time in tail immersion test and pain score in formalin induced pain in Wistar rats. Also, administration of 50mg/kg CoCl2 do not improve performance of the animals in the experiments.
PMID
Related Publications

Formalin pain is expressed in decerebrate rats but not attenuated by morphine.

The antinociceptive effect of stimulating the retrosplenial cortex in the rat tail-flick test but not in the formalin test involves the rostral anterior cingulate cortex.

Pain threshold variations in female rats as a function of the estrus cycle.

Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat.

Antinociceptive effect of certain dimethoxy flavones in mice.

Authors

Mayor MeshTerms

Formaldehyde

Keywords
Journal Title nigerian journal of physiological sciences : official publication of the physiological society of nigeria
Publication Year Start




PMID- 28262853
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170315
LR  - 20170315
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar 06
TI  - Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and
      Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II)
      Chloride.
PG  - 161-164
AB  - Lead (Pb) is cheap and there is a long tradition of its use, but its toxic
      effects have also been recognized. There is increased public health concern
      regarding the hazards of low dose Pb exposure to adults and children. Studies
      have shown the risks for hypertension, decrements in renal function, subtle
      decline in cognitive function, and adverse reproductive outcome at low blood Pb
      level. In this study, the possible modulatory role of cobalt (II) chloride
      (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain
      was investigated. Twenty adult Wistar rats of both sexes (weight 150g to 200g)
      were used. The animals were divided into four groups (n = 5) and administered Pb 
      (5mg/kg), Pb (5mg/kg) + CoCl2 (50mg/kg) and CoCl2 (50mg/kg) orally for
      twenty-eight days. The last group served as control and were given distilled
      water only. In the tail immersion test, there was no significant change in
      reaction time for all three groups when compared to the control. In the
      formalin-induced pain, pain score after five and forty-five minutes also do not
      show significant change for all the three groups when compared to control. This
      work suggested that exposure to 5mg/kg Pb for twenty-eight days do not
      significantly impair reaction time in tail immersion test and pain score in
      formalin induced pain in Wistar rats. Also, administration of 50mg/kg CoCl2 do
      not improve performance of the animals in the experiments.
FAU - Umar, A H
AU  - Umar AH
AD  - Department of Human Physiology, Faculty of Medicine, Ahmadu Bello University,
      Zaria. [email protected]
FAU - Suleiman, I
AU  - Suleiman I
FAU - Muhammed, H
AU  - Muhammed H
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Organometallic Compounds)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 3G0H8C9362 (Cobalt)
RN  - EVS87XF13W (cobaltous chloride)
RN  - RX077P88RY (lead acetate)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cobalt/*pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - *Formaldehyde
MH  - Male
MH  - Organometallic Compounds/*pharmacology
MH  - Pain/chemically induced/physiopathology/*psychology
MH  - Pain Perception/*drug effects
MH  - Rats, Wistar
MH  - Reaction Time/drug effects
MH  - Time Factors
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO  - Niger J Physiol Sci. 2017 Mar 6;31(2):161-164.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>