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Effect of Insulin on Visuo-Spatial Memory and Histology of Cerebral Cortex in the Presence or Absence of Nitric Oxide Inhibition.

Abstract Insulin has emerged from its traditional 'peripheral' glucose-lowering function to become increasingly regarded as a brain hormone that controls a wide range of functions including learning and memory. Insulin action on learning and memory is linked to nitric oxide (NO) signalling, but its effects on memory and histology of cerebral cortex in conditions of varied NO availability is unclear. This research sought to determine the effect of insulin on visuo-spatial learning, memory and histology of cerebral cortex during NO deficiency. Twenty-four mice weighing 21-23 g, were divided into four groups (n = 6) and treated daily for seven days with 0.2 ml distilled water subcutaneously (s.c.) (control), 10 I.U/kg insulin s.c., 10 I.U/kg insulin + 50 mg/kg L-NAME intraperitoneally (i.p.), and 50 mg/kg i.p. L-NAME s.c., respectively. The 3-day MWM paradigm was used to assess memory. Brain tissue was examined for histological changes. There was no significant difference between day 1 and day 2 latencies for all the groups. The mice in all (but L-NAME) groups spent more time in the target quadrant, and the difference was significant within but not between groups. There was significant reduction in number of platform site crossings (4.83 ± 0.5, 0.67 ± 0.3, 0.50 ± 0.3 and 0.50 ± 0.3 for control, insulin, insulin+L-NAME and L-NAME groups, respectively) in all the groups compared to control. Normal histology of the cortex and absence of histological lesions were observed in brain slides of control and treatment groups. It was concluded that insulin administration impairs visuo-spatial memory to a greater extent in the presence of NO block, and to a lesser extent in the absence of NO block. Nitric oxide has a role in insulin-induced memory impairment. Insulin administration in the presence or absence of NO block had no effect on histology of cortex.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title nigerian journal of physiological sciences : official publication of the physiological society of nigeria
Publication Year Start




PMID- 28262854
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170315
LR  - 20170315
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar 06
TI  - Effect of Insulin on Visuo-Spatial Memory and Histology of Cerebral Cortex in the
      Presence or Absence of Nitric Oxide Inhibition.
PG  - 165-170
AB  - Insulin has emerged from its traditional 'peripheral' glucose-lowering function
      to become increasingly regarded as a brain hormone that controls a wide range of 
      functions including learning and memory. Insulin action on learning and memory is
      linked to nitric oxide (NO) signalling, but its effects on memory and histology
      of cerebral cortex in conditions of varied NO availability is unclear. This
      research sought to determine the effect of insulin on visuo-spatial learning,
      memory and histology of cerebral cortex during NO deficiency. Twenty-four mice
      weighing 21-23 g, were divided into four groups (n = 6) and treated daily for
      seven days with 0.2 ml distilled water subcutaneously (s.c.) (control), 10 I.U/kg
      insulin s.c., 10 I.U/kg insulin + 50 mg/kg L-NAME intraperitoneally (i.p.), and
      50 mg/kg i.p. L-NAME s.c., respectively. The 3-day MWM paradigm was used to
      assess memory. Brain tissue was examined for histological changes. There was no
      significant difference between day 1 and day 2 latencies for all the groups. The 
      mice in all (but L-NAME) groups spent more time in the target quadrant, and the
      difference was significant within but not between groups. There was significant
      reduction in number of platform site crossings (4.83 +/- 0.5, 0.67 +/- 0.3, 0.50 
      +/- 0.3 and 0.50 +/- 0.3 for control, insulin, insulin+L-NAME and L-NAME groups, 
      respectively) in all the groups compared to control. Normal histology of the
      cortex and absence of histological lesions were observed in brain slides of
      control and treatment groups. It was concluded that insulin administration
      impairs visuo-spatial memory to a greater extent in the presence of NO block, and
      to a lesser extent in the absence of NO block. Nitric oxide has a role in
      insulin-induced memory impairment. Insulin administration in the presence or
      absence of NO block had no effect on histology of cortex.
FAU - Yarube, I U
AU  - Yarube IU
AD  - Department of Physiology, Faculty of Basic Medical Sciences, College of Health
      Sciences, Bayero University, Kano. [email protected]
FAU - Ayo, J O
AU  - Ayo JO
FAU - Fatihu, M Y
AU  - Fatihu MY
FAU - Magaji, R A
AU  - Magaji RA
FAU - Umar, I A
AU  - Umar IA
FAU - Alhassan, A W
AU  - Alhassan AW
FAU - Saleh, M Ia
AU  - Saleh MI
LA  - eng
PT  - Journal Article
DEP - 20170306
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the
      Physiological Society of Nigeria
JID - 8811109
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Insulin)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cerebral Cortex/*drug effects/metabolism/physiopathology
MH  - Cognition/drug effects
MH  - Enzyme Inhibitors/*toxicity
MH  - Female
MH  - Insulin/*toxicity
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*chemically induced/metabolism/physiopathology/psychology
MH  - Mice
MH  - Motor Activity/drug effects
MH  - NG-Nitroarginine Methyl Ester/*toxicity
MH  - Nitric Oxide/deficiency/*metabolism
MH  - Nitric Oxide Synthase/*antagonists & inhibitors/metabolism
MH  - Spatial Learning/*drug effects
MH  - Spatial Memory/*drug effects
MH  - Time Factors
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO  - Niger J Physiol Sci. 2017 Mar 6;31(2):165-170.

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