OWN - NLM
DA - 20170306
LR - 20170315
IS - 0794-859X (Print)
IS - 0794-859X (Linking)
VI - 31
IP - 2
DP - 2017 Mar 06
TI - Studies on Zinc and Copper Ion in Relation to Wound Healing in Male and Female
West African Dwarf Goats.
PG - 171-176
AB - Wound healing remains a challenging clinical problem for which precise and
efficient management is essential in order to curtail morbidity and mortality.
Wound healing has been shown to depend upon the availability of appropriate trace
elements like copper and zinc which serve as enzyme cofactors and structural
components in tissue repair. This study aims at evaluating the distribution of
zinc and copper found in the hair as well as skin during epidermal wound healing.
Adult and healthy West African dwarf (WAD) goats of both sexes fed with
concentrate, grass, cassava peel and water ad libitum were used. The animals were
housed for three weeks before commencement of the experiments. Epidermal wounds
were created on the trunks of all the goats using cardboard template of 1cm(2).
Progressive changes in wound contraction were monitored grossly by placing clean
and sterile venier calliper on the wound margin. Hair and skin elemental (copper
and zinc) analyses were done using atomic absorption spectroscopy (AAS).
Significant increases in Cu level were observed in the female hair compared with
that of males. There were significant increases in the Zn levels of the females'
hair compared with the males. The wound healed faster in female goat compared
with the males. The ratio of copper to zinc is clinically more important than the
concentration of either of these trace metals. The pattern of distribution
between zinc and copper concentration in the skin and hair of the male and female
goats observed in this study could be added factor responsible for early wound
healing in female. Therefore, our findings suggest that the distribution in the
Cu and Zinc level in skin and hair of both male and female goats could also be a
factor for wound healing in the animals.
FAU - Olaifa, A K
AU - Olaifa AK
AD - Department of Veterinary Surgery and Reproduction, University of Ibadan, Ibadan.
FAU - Fadason, S T
AU - Fadason ST
LA - eng
PT - Comparative Study
PT - Journal Article
DEP - 20170306
PL - Nigeria
TA - Niger J Physiol Sci
JT - Nigerian journal of physiological sciences : official publication of the
Physiological Society of Nigeria
JID - 8811109
RN - 789U1901C5 (Copper)
RN - J41CSQ7QDS (Zinc)
SB - IM
MH - Animals
MH - Copper/*metabolism
MH - Disease Models, Animal
MH - Epidermis/injuries/*metabolism/pathology
MH - Female
MH - Goats
MH - Hair/metabolism
MH - Male
MH - Sex Factors
MH - Time Factors
MH - *Wound Healing
MH - Wounds, Penetrating/*metabolism/pathology
MH - Zinc/*metabolism
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO - Niger J Physiol Sci. 2017 Mar 6;31(2):171-176.