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Studies on Zinc and Copper Ion in Relation to Wound Healing in Male and Female West African Dwarf Goats.

Abstract Wound healing remains a challenging clinical problem for which precise and efficient management is essential in order to curtail morbidity and mortality. Wound healing has been shown to depend upon the availability of appropriate trace elements like copper and zinc which serve as enzyme cofactors and structural components in tissue repair. This study aims at evaluating the distribution of zinc and copper found in the hair as well as skin during epidermal wound healing. Adult and healthy West African dwarf (WAD) goats of both sexes fed with concentrate, grass, cassava peel and water ad libitum were used. The animals were housed for three weeks before commencement of the experiments. Epidermal wounds were created on the trunks of all the goats using cardboard template of 1cm². Progressive changes in wound contraction were monitored grossly by placing clean and sterile venier calliper on the wound margin. Hair and skin elemental (copper and zinc) analyses were done using atomic absorption spectroscopy (AAS). Significant increases in Cu level were observed in the female hair compared with that of males. There were significant increases in the Zn levels of the females' hair compared with the males. The wound healed faster in female goat compared with the males. The ratio of copper to zinc is clinically more important than the concentration of either of these trace metals. The pattern of distribution between zinc and copper concentration in the skin and hair of the male and female goats observed in this study could be added factor responsible for early wound healing in female. Therefore, our findings suggest that the distribution in the Cu and Zinc level in skin and hair of both male and female goats could also be a factor for wound healing in the animals.
PMID
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Authors

Mayor MeshTerms

Wound Healing

Keywords
Journal Title nigerian journal of physiological sciences : official publication of the physiological society of nigeria
Publication Year Start




PMID- 28262855
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170315
LR  - 20170315
IS  - 0794-859X (Print)
IS  - 0794-859X (Linking)
VI  - 31
IP  - 2
DP  - 2017 Mar 06
TI  - Studies on Zinc and Copper Ion in Relation to Wound Healing in Male and Female
      West African Dwarf Goats.
PG  - 171-176
AB  - Wound healing remains a challenging clinical problem for which precise and
      efficient management is essential in order to curtail morbidity and mortality.
      Wound healing has been shown to depend upon the availability of appropriate trace
      elements like copper and zinc which serve as enzyme cofactors and structural
      components in tissue repair. This study aims at evaluating the distribution of
      zinc and copper found in the hair as well as skin during epidermal wound healing.
      Adult and healthy West African dwarf (WAD) goats of both sexes fed with
      concentrate, grass, cassava peel and water ad libitum were used. The animals were
      housed for three weeks before commencement of the experiments. Epidermal wounds
      were created on the trunks of all the goats using cardboard template of 1cm(2).
      Progressive changes in wound contraction were monitored grossly by placing clean 
      and sterile venier calliper on the wound margin. Hair and skin elemental (copper 
      and zinc) analyses were done using atomic absorption spectroscopy (AAS).
      Significant increases in Cu level were observed in the female hair compared with 
      that of males. There were significant increases in the Zn levels of the females' 
      hair compared with the males. The wound healed faster in female goat compared
      with the males. The ratio of copper to zinc is clinically more important than the
      concentration of either of these trace metals. The pattern of distribution
      between zinc and copper concentration in the skin and hair of the male and female
      goats observed in this study could be added factor responsible for early wound
      healing in female. Therefore, our findings suggest that the distribution in the
      Cu and Zinc level in skin and hair of both male and female goats could also be a 
      factor for wound healing in the animals.
FAU - Olaifa, A K
AU  - Olaifa AK
AD  - Department of Veterinary Surgery and Reproduction, University of Ibadan, Ibadan. 
      akolaifa@yahoo.com.
FAU - Fadason, S T
AU  - Fadason ST
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170306
PL  - Nigeria
TA  - Niger J Physiol Sci
JT  - Nigerian journal of physiological sciences : official publication of the
      Physiological Society of Nigeria
JID - 8811109
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Copper/*metabolism
MH  - Disease Models, Animal
MH  - Epidermis/injuries/*metabolism/pathology
MH  - Female
MH  - Goats
MH  - Hair/metabolism
MH  - Male
MH  - Sex Factors
MH  - Time Factors
MH  - *Wound Healing
MH  - Wounds, Penetrating/*metabolism/pathology
MH  - Zinc/*metabolism
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2017/03/06 [received]
PHST- 2017/03/06 [accepted]
PST - epublish
SO  - Niger J Physiol Sci. 2017 Mar 6;31(2):171-176.

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