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Echocardiographic predictors of outcome in acute heart failure patients in sub-Saharan Africa: insights from THESUS-HF.

Abstract The role of echocardiography in the risk stratification of acute heart failure (HF) is unknown. Some small studies and retrospective analyses have found little change in echocardiographic variables during admission for acute HF and some echocardiographic parameters were not found to be associated with outcomes. It is unknown which echocardiographic variables will predict outcomes in sub-Saharan African patients admitted with acute HF. Using echocardiograms, this study aimed to determine the predictors of death and re-admissions within 60 days and deaths up to 180 days in patients with acute heart failure.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title cardiovascular journal of africa
Publication Year Start




PMID- 28262911
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170314
LR  - 20170314
IS  - 1680-0745 (Electronic)
IS  - 1015-9657 (Linking)
VI  - 28
IP  - 1
DP  - 2017 Jan/Feb
TI  - Echocardiographic predictors of outcome in acute heart failure patients in
      sub-Saharan Africa: insights from THESUS-HF.
PG  - 60-67
LID - 10.5830/CVJA-2016-070 [doi]
AB  - BACKGROUND: The role of echocardiography in the risk stratification of acute
      heart failure (HF) is unknown. Some small studies and retrospective analyses have
      found little change in echocardiographic variables during admission for acute HF 
      and some echocardiographic parameters were not found to be associated with
      outcomes. It is unknown which echocardiographic variables will predict outcomes
      in sub-Saharan African patients admitted with acute HF. Using echocardiograms,
      this study aimed to determine the predictors of death and re-admissions within 60
      days and deaths up to 180 days in patients with acute heart failure. METHODS: Out
      of the 1 006 patients in the THESUS-HF registry, 954 had had an echocardiogram
      performed within a few weeks of admission. Echocardiographic measurements were
      performed according to the American Society of Echocardiography guidelines. We
      examined the associations between each echocardiographic predictor and outcome
      using regression models. RESULTS: Heart rate and left atrial size predicted death
      within 60 days or re-admission. Heart rate, left ventricular posterior wall
      thickness in diastole (PWTd), and presence of aortic stenosis were associated
      with the risk of death within 180 days. PTWd added to clinical variables in
      predicting 180-day mortality rates. CONCLUSIONS: Echocardiographic variables,
      especially those of left ventricular size and function, were not found to have
      additional predictive value in patients admitted for acute HF. Left atrial size, 
      aortic stenosis, heart rate and measures of hypertrophy (LV PWTd) had some
      predictive value, suggesting the importance of early treatment of hypertension
      and severe valvular heart disease.
FAU - Sani, Mahmoud U
AU  - Sani MU
AD  - Department of Medicine, Bayero University Kano; Aminu Kano Teaching Hospital,
      Kano, Nigeria. Email: [email protected]
FAU - Davison, Beth A
AU  - Davison BA
AD  - Momentum Research, Inc, Durham, North Carolina, United States of America.
FAU - Cotter, Gad
AU  - Cotter G
AD  - Momentum Research, Inc, Durham, North Carolina, United States of America.
FAU - Damasceno, Albertino
AU  - Damasceno A
AD  - Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
FAU - Mayosi, Bongani M
AU  - Mayosi BM
AD  - Department of Medicine, GF Jooste and Groote Schuur Hospitals, University of Cape
      Town, Cape Town, South Africa.
FAU - Ogah, Okechukwu S
AU  - Ogah OS
AD  - Department of Medicine, University College Hospital, Ibadan and Ministry of
      Health, Abia State, Nigeria.
FAU - Mondo, Charles
AU  - Mondo C
AD  - Uganda Heart Institute, Kampala, Uganda.
FAU - Dzudie, Anastase
AU  - Dzudie A
AD  - Department of Internal Medicine, Douala General Hospital and Buea Faculty of
      Health Sciences, Douala, Cameroon.
FAU - Ojji, Dike B
AU  - Ojji DB
AD  - Department of Medicine, University of Abuja Teaching Hospital, Abuja, Nigeria.
FAU - Kouam, Charles Kouam
AU  - Kouam CK
AD  - Department of Internal Medicine, Douala General Hospital and Buea Faculty of
      Health Sciences, Douala, Cameroon.
FAU - Suliman, Ahmed
AU  - Suliman A
AD  - Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
FAU - Yonga, Gerald
AU  - Yonga G
AD  - Department of Medicine, Aga Khan University, Nairobi, Kenya.
FAU - Ba, Sergine Abdou
AU  - Ba SA
AD  - Department of Cardiology, Faculty of Medecine, Dakar, Senegal.
FAU - Maru, Fikru
AU  - Maru F
AD  - Addis Cardiac Hospital, Addis Ababa, Ethiopia.
FAU - Alemayehu, Bekele
AU  - Alemayehu B
AD  - Addis Cardiac Hospital, Addis Ababa, Ethiopia.
FAU - Edwards, Christopher
AU  - Edwards C
AD  - Momentum Research, Inc, Durham, North Carolina, United States of America.
FAU - Sliwa, Karen
AU  - Sliwa K
AD  - Hatter Institute for Cardiovascular Research in Africa, Department of Medicine,
      Faculty of Health Sciences, University of Cape Town, South Africa.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PL  - South Africa
TA  - Cardiovasc J Afr
JT  - Cardiovascular journal of Africa
JID - 101313864
SB  - IM
MH  - Acute Disease
MH  - Africa South of the Sahara/epidemiology
MH  - Echocardiography/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*diagnosis/epidemiology/physiopathology
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume/physiology
MH  - Survival Rate/trends
MH  - Ventricular Function, Left/physiology
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
PHST- 2015/07/12 [received]
PHST- 2016/07/10 [accepted]
AID - 10.5830/CVJA-2016-070 [doi]
PST - ppublish
SO  - Cardiovasc J Afr. 2017 Jan/Feb;28(1):60-67. doi: 10.5830/CVJA-2016-070.

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