PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28263096
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170314
LR  - 20170314
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 123
IP  - 2
DP  - 2017 May
TI  - Glutamine dipeptide and cortisol change the liver glucose metabolism and reduce
      the severity of insulin-induced hypoglycaemia in untreated T1DM Swiss mice.
PG  - 134-144
LID - 10.1080/13813455.2016.1273364 [doi]
AB  - CONTEXT: Glutamine is conditionally essential in type 1 diabetes mellitus, and
      might be useful to counteract hypoglycaemia. OBJECTIVE: To investigate the
      systemic and hepatic effects of counter-regulatory hormones and glutamine
      dipeptide (GDP) during hypoglycemic episodes. MATERIALS AND METHODS: Diabetic
      Swiss mice made hypoglycaemic by insulin injection (1 U/kg) were given
      counter-regulatory hormones and/or GDP. Sixty minutes later, liver histology,
      liver glucose metabolism and plasma were assessed. RESULTS: Combined, cortisol
      and GDP improved the hypoglycemic profile. During liver perfusion,
      gluconeogenesis was possibly the major pathway leading to glucose release.
      Perfusion with gluconeogenic precursors after glycogen depletion by adrenaline
      increased liver glucose and urea release. DISCUSSION: The less severe
      hypoglycaemia could result from cortisol stimulating periportal gluconeogenesis
      and GDP inhibiting pericentral glycogenolysis, both favouring liver glucose
      release. CONCLUSIONS: At least some benefits of GDP and cortisol during
      hypoglycaemia came from their hepatic actions, and their use in diabetic patients
      should be explored.
FAU - Bataglini, Camila
AU  - Bataglini C
AD  - a Program of Graduate Studies in Biological Sciences, State University of Maringa
      , Maringa , Brazil.
FAU - Rezende, Diego G L
AU  - Rezende DG
AD  - b Undergraduation in Physical Education, State University of Maringa , Maringa , 
      Brazil.
FAU - Primo, Marcos A
AU  - Primo MA
AD  - b Undergraduation in Physical Education, State University of Maringa , Maringa , 
      Brazil.
FAU - Gomes, Celia R G
AU  - Gomes CR
AD  - c Department of Morphological Sciences , State University of Maringa , Maringa , 
      Brazil , and.
FAU - Pedrosa, Maria M D
AU  - Pedrosa MM
AD  - d Department of Physiological Sciences , State University of Maringa , Maringa , 
      Brazil.
FAU - Godoi, Vilma A F
AU  - Godoi VA
AD  - d Department of Physiological Sciences , State University of Maringa , Maringa , 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170112
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Dipeptides)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0RH81L854J (Glutamine)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Experimental/*physiopathology
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Dipeptides/pharmacology
MH  - Gluconeogenesis/drug effects
MH  - Glutamine/*pharmacology
MH  - Hydrocortisone/*pharmacology
MH  - Hypoglycemia/chemically induced/*prevention & control
MH  - Hypoglycemic Agents/toxicity
MH  - Insulin/*toxicity
MH  - Liver/drug effects/*metabolism
MH  - Male
MH  - Mice
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Type 1 diabetes mellitus
OT  - counter-regulation
OT  - gluconeogenesis
OT  - glucose homeostasis
OT  - liver perfusion
EDAT- 2017/03/07 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/07 06:00
AID - 10.1080/13813455.2016.1273364 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2017 May;123(2):134-144. doi:
      10.1080/13813455.2016.1273364. Epub 2017 Jan 12.

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