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Modelling the effects of blood component storage lesions on the quality of haemostatic resuscitation in massive transfusion for trauma.

Abstract All blood components undergo loss of potency during storage. These loss-of-potency storage lesions are important in trauma resuscitation because they reduce the haemostatic capacity of mixtures of components that attempt to reconstitute whole blood. Even red cell storage-related loss of potency, which averages 17% with modern additive solutions, is important because 6 units of red cells must be given to achieve the effect of 5 fully potent units.
PMID
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Authors

Mayor MeshTerms

Models, Biological

Keywords
Journal Title blood transfusion = trasfusione del sangue
Publication Year Start




PMID- 28263173
OWN - NLM
STAT- MEDLINE
DA  - 20170306
DCOM- 20170310
LR  - 20170310
IS  - 1723-2007 (Print)
IS  - 1723-2007 (Linking)
VI  - 15
IP  - 2
DP  - 2017 Mar
TI  - Modelling the effects of blood component storage lesions on the quality of
      haemostatic resuscitation in massive transfusion for trauma.
PG  - 153-157
LID - 10.2450/2017.0310-16 [doi]
AB  - BACKGROUND: All blood components undergo loss of potency during storage. These
      loss-of-potency storage lesions are important in trauma resuscitation because
      they reduce the haemostatic capacity of mixtures of components that attempt to
      reconstitute whole blood. Even red cell storage-related loss of potency, which
      averages 17% with modern additive solutions, is important because 6 units of red 
      cells must be given to achieve the effect of 5 fully potent units. MATERIALS AND 
      METHODS: Loss of potency of stored units of red blood cells, plasma, platelets,
      and cryoprecipitate were summed for dilutional, storage-related, pathogen
      reduction-related, and splenic sequestration-related causes and expressed as
      fractional plasma coagulation factor concentrations and platelet counts. RESULTS:
      Production of reconstituted whole blood from 1:1:1 unit ratios of red
      cells:plasma:platelets is associated with a 38% loss of plasma coagulation factor
      concentration and 56% loss of platelets. Storage losses of 17% for red cells, 10%
      for coagulation factors, and 30% for platelets are additive to pathogen
      reduction-related losses of 18% for coagulation factors and 30% for platelets.
      DISCUSSION: Component preparation and storage-related losses of potency for all
      blood components are serious problems for trauma resuscitation. Even red cell
      storage contributes to this problem and this can be made better in ways that can 
      save many lives each year.
FAU - Mays, James A
AU  - Mays JA
AD  - Department of Laboratory Medicine, University of Washington School of Medicine,
      Seattle, WA, United States of America.
FAU - Hess, John R
AU  - Hess JR
AD  - Department of Laboratory Medicine, University of Washington School of Medicine,
      Seattle, WA, United States of America.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
SB  - IM
MH  - Blood Component Transfusion/*methods
MH  - Blood Preservation/*methods
MH  - Humans
MH  - *Models, Biological
MH  - Resuscitation/*methods
MH  - Wounds and Injuries/*therapy
EDAT- 2017/03/07 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/11/08 [received]
PHST- 2016/11/21 [accepted]
AID - 2017.0310-16 [pii]
AID - 10.2450/2017.0310-16 [doi]
PST - ppublish
SO  - Blood Transfus. 2017 Mar;15(2):153-157. doi: 10.2450/2017.0310-16.

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