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Iron-deficient erythropoiesis in blood donors and red blood cell recovery after transfusion: initial studies with a mouse model.

Abstract Most frequent red cell (RBC) donors and many first-time donors are iron deficient, but meet haemoglobin standards. However, the effects of donation-induced iron deficiency on RBC storage quality are unknown. Thus, we used a mouse model to determine if donor iron deficiency reduced post-transfusion RBC recovery.
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Journal Title blood transfusion = trasfusione del sangue
Publication Year Start




PMID- 28263174
OWN - NLM
STAT- In-Process
DA  - 20170306
LR  - 20170306
IS  - 1723-2007 (Print)
IS  - 1723-2007 (Linking)
VI  - 15
IP  - 2
DP  - 2017 Mar
TI  - Iron-deficient erythropoiesis in blood donors and red blood cell recovery after
      transfusion: initial studies with a mouse model.
PG  - 158-164
LID - 10.2450/2017.0349-16 [doi]
AB  - BACKGROUND: Most frequent red cell (RBC) donors and many first-time donors are
      iron deficient, but meet haemoglobin standards. However, the effects of
      donation-induced iron deficiency on RBC storage quality are unknown. Thus, we
      used a mouse model to determine if donor iron deficiency reduced post-transfusion
      RBC recovery. METHODS: Weanling mice received a control diet or an iron-deficient
      diet. A third group receiving the iron-deficient diet was also phlebotomised
      weekly. This provided 3 groups of mice with different iron status: (1) iron
      replete, (2) mild iron deficiency with iron-deficient erythropoiesis, and (3)
      iron-deficiency anaemia. At ten weeks of age, blood was collected, leucoreduced, 
      and stored at 4 masculineC. After 12 days of storage, 24-hour (h)
      post-transfusion RBC recovery was quantified in recipients by flow cytometry.
      RESULTS: Before blood collection, mean haemoglobin concentrations in the
      iron-replete, iron-deficient, and iron-deficiency anaemia donor mice were
      16.5+/-0.4, 11.5+/-0.4, and 7.0+/-1.4 [g/dL+/- 1 standard deviation (SD)],
      respectively (p<0.01 for all comparisons between groups). The 24-h
      post-transfusion RBC recoveries in recipients receiving transfusions from these
      three cohorts were 77.1+/-13.2, 66.5+/-10.9, and 46.7+/-15.9 (% +/-1 SD),
      respectively (p<0.05 for all comparisons between groups). DISCUSSION: In summary,
      donor iron deficiency significantly reduced 24-h post-transfusion RBC recovery in
      recipient mice. RBCs from mice with mild iron deficiency and iron-deficient
      erythropoiesis, with haemoglobin levels similar to those used for human
      autologous blood donation, had intermediate post-transfusion RBC recovery, as
      compared to iron-replete donors and those with iron-deficiency anaemia. This
      suggests that, in addition to the effects of iron deficiency on donor health,
      frequent blood donation, leading to iron-deficient erythropoiesis, may also have 
      adverse effects for transfusion recipients.
FAU - Bandyopadhyay, Sheila
AU  - Bandyopadhyay S
AD  - Department of Pathology and Cell Biology, Columbia University, New York, NY,
      United States of America.
FAU - Brittenham, Gary M
AU  - Brittenham GM
AD  - Department of Pediatrics, Columbia University, New York, NY, United States of
      America.
FAU - Francis, Richard O
AU  - Francis RO
AD  - Department of Pathology and Cell Biology, Columbia University, New York, NY,
      United States of America.
FAU - Zimring, James C
AU  - Zimring JC
AD  - BloodWorksNW and Departments of Laboratory Medicine and Internal Medicine,
      University of Washington, Seattle, WA, United States of America.
FAU - Hod, Eldad A
AU  - Hod EA
AD  - Department of Pathology and Cell Biology, Columbia University, New York, NY,
      United States of America.
FAU - Spitalnik, Steven L
AU  - Spitalnik SL
AD  - Department of Pathology and Cell Biology, Columbia University, New York, NY,
      United States of America.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Blood Transfus
JT  - Blood transfusion = Trasfusione del sangue
JID - 101237479
EDAT- 2017/03/07 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/03/07 06:00
PHST- 2016/12/09 [received]
PHST- 2016/12/16 [accepted]
AID - 2017.0349-16 [pii]
AID - 10.2450/2017.0349-16 [doi]
PST - ppublish
SO  - Blood Transfus. 2017 Mar;15(2):158-164. doi: 10.2450/2017.0349-16.

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