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Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma.

Abstract Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA) from donor to recipient cells. Notably, tumor-derived exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.
PMID
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Authors

Mayor MeshTerms

Exosomes

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28265569
OWN - NLM
STAT- MEDLINE
DA  - 20170307
DCOM- 20170309
LR  - 20170309
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular
      Carcinoma.
PG  - 2931813
LID - 10.1155/2017/2931813 [doi]
AB  - Exosomes are important in intercellular communication. They assure the horizontal
      transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, 
      and circulating DNA) from donor to recipient cells. Notably, tumor-derived
      exosomes (TDEs) appear to be an important vehicle of specific signals in cancer, 
      impacting on tumor growth and metastasis. Recent researches point to the
      characterization of exosomes in Hepatocellular Carcinoma (HCC), the major adult
      liver malignancy. In this review, we summarize current findings on HCC exosomes, 
      focusing on the identification of noncoding RNAs as exosome-enriched functional
      regulators and new potential biomarkers. The great potential of exosomes in
      future HCC diagnostic and therapeutic approaches is underlined.
FAU - Santangelo, Laura
AU  - Santangelo L
AUID- ORCID: 0000-0002-9432-262X
AD  - National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
FAU - Battistelli, Cecilia
AU  - Battistelli C
AUID- ORCID: 0000-0002-5611-7377
AD  - Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular
      Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
FAU - Montaldo, Claudia
AU  - Montaldo C
AD  - National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
FAU - Citarella, Franca
AU  - Citarella F
AUID- ORCID: 0000-0001-9946-6190
AD  - Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular
      Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
FAU - Strippoli, Raffaele
AU  - Strippoli R
AD  - Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular
      Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
FAU - Cicchini, Carla
AU  - Cicchini C
AUID- ORCID: 0000-0003-4662-5674
AD  - Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Cellular
      Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170207
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Adult
MH  - Animals
MH  - Carcinoma, Hepatocellular/*metabolism/pathology/*therapy
MH  - *Exosomes
MH  - Humans
MH  - Liver Neoplasms/*metabolism/pathology/*therapy
PMC - PMC5318635
COI - All authors declare that they have no potential conflicts (financial,
      professional, or personal) that are relevant to the manuscript.
EDAT- 2017/03/08 06:00
MHDA- 2017/03/10 06:00
CRDT- 2017/03/08 06:00
PHST- 2016/10/09 [received]
PHST- 2016/12/15 [revised]
PHST- 2017/01/04 [accepted]
AID - 10.1155/2017/2931813 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:2931813. doi: 10.1155/2017/2931813. Epub 2017 Feb 7.

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