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Current Approach to the Evaluation and Management of Microscopic Colitis.

Abstract Microscopic colitis is a common cause of chronic watery diarrhea, particularly in the elderly. The accompanying symptoms, which include abdominal pain and fatigue, can markedly impair patients' quality of life. Diagnosis is based upon characteristic histologic findings of the colonic mucosa. This review focuses on the current approach to evaluation and management of patients with microscopic colitis.
PMID
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Authors

Mayor MeshTerms
Keywords

Large intestine

Microscopic colitis

Microscopic colitis management

Microscopic colitis treatment

Journal Title current gastroenterology reports
Publication Year Start




PMID- 28265892
OWN - NLM
STAT- MEDLINE
DA  - 20170307
DCOM- 20170313
LR  - 20170313
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Linking)
VI  - 19
IP  - 2
DP  - 2017 Feb
TI  - Current Approach to the Evaluation and Management of Microscopic Colitis.
PG  - 8
LID - 10.1007/s11894-017-0551-3 [doi]
AB  - PURPOSE OF REVIEW: Microscopic colitis is a common cause of chronic watery
      diarrhea, particularly in the elderly. The accompanying symptoms, which include
      abdominal pain and fatigue, can markedly impair patients' quality of life.
      Diagnosis is based upon characteristic histologic findings of the colonic mucosa.
      This review focuses on the current approach to evaluation and management of
      patients with microscopic colitis. RECENT FINDINGS: Although the incidence of
      microscopic colitis has been increasing over time, recent epidemiological studies
      show stabilization at 21.0-24.7 cases per 100,000 person-years. Recent research
      has further expanded our knowledge of the underlying pathophysiology and
      emphasized the entity of drug-induced microscopic colitis and the association
      with celiac disease. Two recent randomized studies have confirmed the
      effectiveness of oral budesonide for both induction and maintenance treatment of 
      microscopic colitis and is now endorsed by the American Gastroenterological
      Association as first-line treatment. The incidence of microscopic colitis has
      stabilized at just over 20 cases per 100,000 person-years. Celiac disease and
      drug-induced microscopic colitis should be considered in all patients diagnosed
      with microscopic colitis. There are a number of treatments available for patients
      with microscopic colitis; however, budesonide is the only option well studied in 
      controlled trials and is effective for both induction and maintenance treatment.
FAU - Cotter, Thomas G
AU  - Cotter TG
AD  - Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
FAU - Pardi, Darrell S
AU  - Pardi DS
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW,
      Rochester, MN, 55905, USA. pardi.darrell@mayo.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
RN  - 0 (Glucocorticoids)
RN  - 51333-22-3 (Budesonide)
SB  - IM
MH  - Budesonide/therapeutic use
MH  - Colitis, Microscopic/complications/*diagnosis/drug therapy
MH  - Diarrhea/etiology
MH  - Disease Management
MH  - Glucocorticoids/therapeutic use
MH  - Humans
OTO - NOTNLM
OT  - Large intestine
OT  - Microscopic colitis
OT  - Microscopic colitis management
OT  - Microscopic colitis treatment
EDAT- 2017/03/08 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/08 06:00
AID - 10.1007/s11894-017-0551-3 [doi]
AID - 10.1007/s11894-017-0551-3 [pii]
PST - ppublish
SO  - Curr Gastroenterol Rep. 2017 Feb;19(2):8. doi: 10.1007/s11894-017-0551-3.

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