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Koala retrovirus genotyping analyses reveal a low prevalence of KoRV-A in Victorian koalas and an association with clinical disease.

Abstract Koala retrovirus (KoRV) is undergoing endogenization into the genome of koalas in Australia, providing an opportunity to assess the effect of retrovirus infection on the health of a population. The prevalence of KoRV in north-eastern Australia (Queensland and New South Wales) is 100 %, whereas previous preliminary investigations in south-eastern Australia (Victoria) suggested KoRV is present at a lower prevalence, although the values have varied widely. Here, we describe a large study of free-ranging koalas in Victoria to estimate the prevalence of KoRV and assess the clinical significance of KoRV infection in wild koalas.
PMID
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Koala retrovirus (KoRV) genotyping analyses reveal a low prevalence of KoRV-A in Victorian koalas and an association with clinical disease.

Authors

Mayor MeshTerms
Keywords
Journal Title journal of medical microbiology
Publication Year Start




PMID- 28266284
OWN - NLM
STAT- MEDLINE
DA  - 20170307
DCOM- 20170315
LR  - 20170315
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 66
IP  - 2
DP  - 2017 Feb
TI  - Koala retrovirus genotyping analyses reveal a low prevalence of KoRV-A in
      Victorian koalas and an association with clinical disease.
PG  - 236-244
LID - 10.1099/jmm.0.000416 [doi]
AB  - PURPOSE: Koala retrovirus (KoRV) is undergoing endogenization into the genome of 
      koalas in Australia, providing an opportunity to assess the effect of retrovirus 
      infection on the health of a population. The prevalence of KoRV in north-eastern 
      Australia (Queensland and New South Wales) is 100 %, whereas previous preliminary
      investigations in south-eastern Australia (Victoria) suggested KoRV is present at
      a lower prevalence, although the values have varied widely. Here, we describe a
      large study of free-ranging koalas in Victoria to estimate the prevalence of KoRV
      and assess the clinical significance of KoRV infection in wild koalas.
      METHODOLOGY: Blood or spleen samples from 648 koalas where tested for KoRV
      provirus, and subsequently genotyped, using PCRs to detect the pol and env genes 
      respectively. Clinical data was also recorded where possible and analysed in
      comparison to infection status. RESULTS: The prevalence of KoRV was 24.7 %
      (160/648). KoRV-A was detected in 141/160 cases, but KoRV-B, a genotype
      associated with neoplasia in captive koalas, was not detected. The genotype in 19
      cases could not be determined. Genomic differences between KoRV in Victoria and
      type strains may have impacted genotyping. Factors associated with KoRV
      infection, based on multivariable analysis, were low body condition score, region
      sampled, and 'wet bottom' (a staining of the fur around the rump associated with 
      chronic urinary incontinence). Koalas with wet bottom were nearly twice as likely
      to have KoRV provirus detected than those without wet bottom (odds ratio=1.90, 95
      % confidence interval 1.21, 2.98). CONCLUSION: Our findings have important
      implications for the conservation of this iconic species, particularly regarding 
      translocation potential of Victorian koalas.
FAU - Legione, Alistair R
AU  - Legione AR
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Patterson, Jade L S
AU  - Patterson JL
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia 2Veterinary
      Department, Melbourne Zoo, Parkville, Victoria, Australia.
FAU - Whiteley, Pam
AU  - Whiteley P
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia 3Wildlife
      Health Surveillance Victoria, The University of Melbourne, Werribee, Victoria,
      Australia.
FAU - Firestone, Simon M
AU  - Firestone SM
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Curnick, Megan
AU  - Curnick M
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia 4Australian
      Wildlife Health Centre, Healesville Sanctuary, Healesville, Victoria, Australia.
FAU - Bodley, Kate
AU  - Bodley K
AD  - 2Veterinary Department, Melbourne Zoo, Parkville, Victoria, Australia.
FAU - Lynch, Michael
AU  - Lynch M
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia 2Veterinary
      Department, Melbourne Zoo, Parkville, Victoria, Australia.
FAU - Gilkerson, James R
AU  - Gilkerson JR
AD  - 5Centre for Equine Infectious Diseases, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Sansom, Fiona M
AU  - Sansom FM
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
FAU - Devlin, Joanne M
AU  - Devlin JM
AD  - 1Asia Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural
      Sciences, The University of Melbourne, Parkville, Victoria, Australia.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - DNA, Viral/genetics
MH  - Genotype
MH  - Genotyping Techniques
MH  - Logistic Models
MH  - Multivariate Analysis
MH  - New South Wales/epidemiology
MH  - Phascolarctidae/*virology
MH  - Prevalence
MH  - Queensland/epidemiology
MH  - Retroviridae/genetics/*isolation & purification
MH  - Retroviridae Infections/epidemiology/*veterinary
EDAT- 2017/03/08 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/08 06:00
AID - 10.1099/jmm.0.000416 [doi]
PST - ppublish
SO  - J Med Microbiol. 2017 Feb;66(2):236-244. doi: 10.1099/jmm.0.000416.

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