PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.

Abstract In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed.
PMID
Related Publications

Image of the month. Wermer syndrome and Zollinger-Ellison syndrome.

Regression of type II gastric carcinoids in multiple endocrine neoplasia type 1 patients with Zollinger-Ellison syndrome after surgical excision of all gastrinomas.

A case of Zollinger-Ellison syndrome produced by gastrinoma in the duodenum accompanied with multiple endocrine neoplasia type 1.

Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome.

Patients with multiple endocrine neoplasia type 1 with gastrinomas have an increased risk of severe esophageal disease including stricture and the premalignant condition, Barrett's esophagus.

Authors

Mayor MeshTerms
Keywords

Balloon dilation

Esophageal stricture

Hypergastrinemia

Multiple endocrine neoplasm type 1 (MEN1)

Steroid

Ulcer

Journal Title bmc gastroenterology
Publication Year Start




PMID- 28270118
OWN - NLM
STAT- MEDLINE
DA  - 20170308
DCOM- 20170313
LR  - 20170313
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 07
TI  - A case of type 1 multiple endocrine neoplasia with esophageal stricture
      successfully treated with endoscopic balloon dilation and local steroid injection
      combined with surgical resection of gastrinomas.
PG  - 37
LID - 10.1186/s12876-017-0597-6 [doi]
AB  - BACKGROUND: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases
      association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) 
      sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia 
      due to reflux esophagitis with severe esophageal stricture. Treatment for his
      esophageal stricture and ZES was discussed. CASE PRESENTATION: A 43-year-old man 
      with progressive dysphagia and diarrhea was referred to the teaching hospital. He
      had a history of recurrent duodenojejunal perforations despite the anti-secretory
      medication. Blood examinations revealed elevated serum gastrin, calcium, and
      parathyroid hormone. Upper gastrointestinal endoscopy demonstrated a severe
      esophageal stricture, multiple gastroduodenal ulcer scars, and a duodenal
      submucosal tumor. Enhanced computed tomography showed multiple hypervascular
      tumors within the pancreas and duodenum, suggestive of MEN1. Genetic examination 
      demonstrated a pathogenic MEN1 mutation. Repetitive endoscopic esophageal
      dilatation with intralesional corticosteroid injection, coupled with
      pancreatoduodenectomy were performed to improve the patient's symptoms and to
      treat pancreatic tumors. The histology of multiple tumors in the duodenum and
      pancreas were all consistent with neuroendocrine tumors. His hypergastrinemia
      subsided and he remained asymptomatic in his gastrointestinal tract after these
      treatments. CONCLUSION: For esophageal stenosis in case of MEN1/ZES,
      anti-secretory therapy and endoscopic dilatation with corticosteroid injection
      could be recommended. However, in refractory cases with repetitive and/or severe 
      complications due to high acid secretion, surgical treatment could be considered 
      as an option.
FAU - Matsubayashi, Hiroyuki
AU  - Matsubayashi H
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan. [email protected]
AD  - Clinic of Genetic Medicine, Shizuoka Cancer Center, 1007, Shimonagakubo,
      Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan. [email protected]
FAU - Kawata, Noboru
AU  - Kawata N
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
FAU - Kakushima, Naomi
AU  - Kakushima N
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
FAU - Tanaka, Masaki
AU  - Tanaka M
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
FAU - Takizawa, Kohei
AU  - Takizawa K
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
FAU - Kiyozumi, Yoshimi
AU  - Kiyozumi Y
AD  - Clinic of Genetic Medicine, Shizuoka Cancer Center, 1007, Shimonagakubo,
      Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
FAU - Horiuchi, Yasue
AU  - Horiuchi Y
AD  - Clinic of Genetic Medicine, Shizuoka Cancer Center, 1007, Shimonagakubo,
      Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
FAU - Sasaki, Keiko
AU  - Sasaki K
AD  - Division of Pathology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
FAU - Sugiura, Teiichi
AU  - Sugiura T
AD  - Division of Hepato-biliary-pancreatic Surgery, Shizuoka Cancer Center, 1007,
      Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
FAU - Uesaka, Katsuhiko
AU  - Uesaka K
AD  - Division of Hepato-biliary-pancreatic Surgery, Shizuoka Cancer Center, 1007,
      Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
FAU - Ono, Hiroyuki
AU  - Ono H
AD  - Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi,
      Suntogun, Shizuoka, 411-8777, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170307
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Glucocorticoids)
RN  - 1ZK20VI6TY (Triamcinolone)
SB  - IM
MH  - Adult
MH  - Dilatation/methods
MH  - Duodenal Neoplasms/complications/diagnostic imaging/*surgery
MH  - Esophageal Stenosis/etiology/*therapy
MH  - Esophagitis, Peptic/etiology
MH  - Esophagoscopy
MH  - Gastrinoma/complications/diagnostic imaging/*surgery
MH  - Glucocorticoids/*therapeutic use
MH  - Humans
MH  - Injections, Intralesional
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/complications/diagnostic imaging
MH  - Pancreatic Neoplasms/complications/diagnostic imaging/*surgery
MH  - Pancreaticoduodenectomy/methods
MH  - Tomography, X-Ray Computed
MH  - Triamcinolone/*therapeutic use
MH  - Zollinger-Ellison Syndrome/complications/*surgery
PMC - PMC5341352
OTO - NOTNLM
OT  - *Balloon dilation
OT  - *Esophageal stricture
OT  - *Hypergastrinemia
OT  - *Multiple endocrine neoplasm type 1 (MEN1)
OT  - *Steroid
OT  - *Ulcer
EDAT- 2017/03/09 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/09 06:00
PHST- 2016/03/12 [received]
PHST- 2017/03/01 [accepted]
AID - 10.1186/s12876-017-0597-6 [doi]
AID - 10.1186/s12876-017-0597-6 [pii]
PST - epublish
SO  - BMC Gastroenterol. 2017 Mar 7;17(1):37. doi: 10.1186/s12876-017-0597-6.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>