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Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes.

Abstract Dry eye is a common problem in Ophthalmology and may occur for many reasons including Sjogren's syndrome (SS). Recent studies have identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course of SS. The current studies were designed to evaluate how many patients with idiopathic dry eye and no evidence of systemic diseases from a dry eye practice have these autoantibodies.
PMID
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Authors

Mayor MeshTerms
Keywords

Autoantibodies

Corneal abrasion

Dry eyes

Sjogren’s syndrome

Journal Title bmc ophthalmology
Publication Year Start




PMID- 28270126
OWN - NLM
STAT- MEDLINE
DA  - 20170308
DCOM- 20170310
LR  - 20170311
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 07
TI  - Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes.
PG  - 20
LID - 10.1186/s12886-017-0412-8 [doi]
AB  - BACKGROUND: Dry eye is a common problem in Ophthalmology and may occur for many
      reasons including Sjogren's syndrome (SS). Recent studies have identified
      autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6
      (CA6) and anti-parotid secretory protein (PSP), which occur early in the course
      of SS. The current studies were designed to evaluate how many patients with
      idiopathic dry eye and no evidence of systemic diseases from a dry eye practice
      have these autoantibodies. METHODS: Patients from a dry eye clinic and normal
      controls were assessed by Schirmer's test for tear flow. Sera were assessed for
      autoantibodies using ELISA assays. Statistics was performed with Prism 7 software
      and student's unpaired t test. RESULTS: In this study 60% of the dry eye patients
      expressed one of these autoantibodies. Only 30% expressed one of the
      autoantibodies associated with long-standing SS, which are included in the
      diagnostic criteria for SS, anti-Ro and anti-La. Patients with disease for less
      than 2 years and mild dry eyes did not express anti-Ro or anti-La, while 25%
      expressed anti-SP1. Similar observations, with smaller numbers, were made when
      patients had not only dry eye but also dry mouth. CONCLUSIONS: Antibodies to SP1,
      CA6 and PSP occur in some patients with idiopathic dry eyes. Further studies will
      be needed to determine how many of these patients go on to develop systemic
      manifestations of SS. Testing for these autoantibodies may allow early
      recognition of patients with SS. This will lead to improved management of the
      patients and the development of new strategies to maintain normal lacrimal and
      salivary gland function in patients with SS.
FAU - Everett, Sandra
AU  - Everett S
AD  - Department of Ophthalmology, SUNY at Buffalo School of Medicine, Buffalo, NY,
      USA.
FAU - Vishwanath, Sahana
AU  - Vishwanath S
AD  - Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
FAU - Cavero, Vanessa
AU  - Cavero V
AD  - Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
FAU - Shen, Long
AU  - Shen L
AD  - Immco Diagnostics, Buffalo, NY, USA.
FAU - Suresh, Lakshmanan
AU  - Suresh L
AD  - Dental School, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
AD  - Immco Diagnostics, Buffalo, NY, USA.
FAU - Malyavantham, Kishore
AU  - Malyavantham K
AD  - Immco Diagnostics, Buffalo, NY, USA.
FAU - Lincoff-Cohen, Norah
AU  - Lincoff-Cohen N
AD  - Department of Ophthalmology, SUNY at Buffalo School of Medicine, Buffalo, NY,
      USA.
AD  - Department of Neurology, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
FAU - Ambrus, Julian L Jr
AU  - Ambrus JL Jr
AD  - Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
      [email protected]
AD  - Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of
      Medicine, Room C281, Buffalo General Hospital, 100 High Street, Buffalo, NY,
      14203, USA. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170307
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Dry Eye Syndromes/blood/*immunology
MH  - Early Diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunoglobulins/blood
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sjogren's Syndrome/blood/diagnosis/*immunology
PMC - PMC5341407
OTO - NOTNLM
OT  - Autoantibodies
OT  - Corneal abrasion
OT  - Dry eyes
OT  - Sjogren's syndrome
EDAT- 2017/03/09 06:00
MHDA- 2017/03/11 06:00
CRDT- 2017/03/09 06:00
PHST- 2016/07/19 [received]
PHST- 2017/02/11 [accepted]
AID - 10.1186/s12886-017-0412-8 [doi]
AID - 10.1186/s12886-017-0412-8 [pii]
PST - epublish
SO  - BMC Ophthalmol. 2017 Mar 7;17(1):20. doi: 10.1186/s12886-017-0412-8.

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