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Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents.

Abstract A compound herbal formulation (POL4) has been used in the indigenous system of medicine to treat cardiometabolic disorders like diabetes and associated hypertension. POL4 and most of its constituents have not been studied widely for its therapeutic use in hypertension. This study is aimed to determine the efficacy and possible insight into mechanism(s) for the medicinal use of POL4 and its ingredients in hypertension.
PMID
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Authors

Mayor MeshTerms

Chicory

Gymnema sylvestre

Nigella sativa

Plant Preparations

Trigonella

Keywords

Antihypertensive

Ca++ antagonist

POL4

Vasomodulatory

α-adrenergic antagonist

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28270141
OWN - NLM
STAT- MEDLINE
DA  - 20170308
DCOM- 20170314
LR  - 20170314
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 07
TI  - Pharmacological basis for the medicinal use of polyherbal formulation and its
      ingredients in cardiovascular disorders using rodents.
PG  - 142
LID - 10.1186/s12906-017-1644-0 [doi]
AB  - BACKGROUND: A compound herbal formulation (POL4) has been used in the indigenous 
      system of medicine to treat cardiometabolic disorders like diabetes and
      associated hypertension. POL4 and most of its constituents have not been studied 
      widely for its therapeutic use in hypertension. This study is aimed to determine 
      the efficacy and possible insight into mechanism(s) for the medicinal use of POL4
      and its ingredients in hypertension. METHODS: The aqueous methanolic extracts of 
      POL4 (POL4.Cr) and its components [Cichorium intybus (Ci.Cr), Gymnema sylvestre
      (Gs.Cr), Nigella sativa (Ns.Cr) and Trigonella foenum graecum (Tfg.Cr)] were
      tested for blood pressure lowering activity in anaesthetized Sprague-Dawley rats.
      To assess the vasomodulatory effect, isolated tissue experiments were performed
      on rat aortic strips using isometric force transducer coupled with PowerLab data 
      acquisition system. RESULTS: Administration of POL4 to rats caused a
      dose-dependent (1-100 mg/kg) fall in mean arterial pressure (MAP) with maximum
      effect of 85.33 +/- 1.76% at 100 mg/kg, similar to the effect of verapamil. All
      ingredients of POL4 also decreased blood pressure with varying efficacy in
      following order Ns.Cr congruent with Ci.Cr > Tfg.Cr > Gs.Cr. In rat aortic
      preparations, POL4 and its ingredients inhibited K+ (80 mM)-induced contractions,
      Ci.Cr was the most potent followed by Ns.Cr > Tfg.Cr > Gs.Cr congruent with POL4.
      Against phenylephrine (P.E) contractions, Ci.Cr and Tfg.Cr exhibited complete
      relaxation, while POL4.Cr, Gs.Cr and Ns.Cr showed vasomodulatory effect. The Ca++
      antagonist activity was confirmed when POL4 and its ingredients shifted Ca++
      concentrations-response curves to the right in a manner similar to that of
      verapamil. On baseline of rat aorta, the parent formulation and its ingredients
      (except Tfg.Cr) exhibited partially phentolamine (1 muM)-sensitive
      vasoconstriction. CONCLUSION: These data show that POL4 and its constituents
      possess blood pressure lowering activity mediated through inhibition of Ca++
      influx via membranous Ca++ channels and receptor (alpha-adrenergic) operated
      pathways. Thus, this study provides a rationale to the medicinal use of POL4 and 
      its constituents in hypertension.
FAU - Malik, Abdul
AU  - Malik A
AD  - Natural Product Research Division, Department of Biological and Biomedical
      Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University,
      Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan.
AD  - Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan.
FAU - Mehmood, Malik Hassan
AU  - Mehmood MH
AD  - Natural Product Research Division, Department of Biological and Biomedical
      Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University,
      Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan. [email protected]
FAU - Channa, Hajra
AU  - Channa H
AD  - Natural Product Research Division, Department of Biological and Biomedical
      Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University,
      Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan.
AD  - The Aga Khan University Medical College, Stadium Road, P.O. Box 3500, Karachi,
      74800, Pakistan.
FAU - Akhtar, Muhammad Shoaib
AU  - Akhtar MS
AD  - Faculty of Pharmacy, University of Sargodha, Sargodha, 40100, Pakistan.
FAU - Gilani, Anwarul-Hassan
AU  - Gilani AH
AD  - Natural Product Research Division, Department of Biological and Biomedical
      Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University,
      Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan.
AD  - Pakistan Council for Science and Technology, G-5/2, Islamabad, 44000, Pakistan.
LA  - eng
PT  - Journal Article
DEP - 20170307
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Flavonoids)
RN  - 0 (Phenols)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Animals
MH  - Aorta/drug effects
MH  - Blood Pressure/drug effects
MH  - Cardiovascular Diseases/*drug therapy
MH  - *Chicory
MH  - Disease Models, Animal
MH  - Flavonoids/analysis
MH  - Guinea Pigs
MH  - *Gymnema sylvestre
MH  - Heart Atria/drug effects
MH  - Hypertension/*drug therapy
MH  - *Nigella sativa
MH  - Phenols/analysis
MH  - Phytotherapy/*methods
MH  - *Plant Preparations/chemistry/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Trigonella
MH  - Vasoconstriction/drug effects
PMC - PMC5341478
OTO - NOTNLM
OT  - Antihypertensive
OT  - Ca++ antagonist
OT  - POL4
OT  - Vasomodulatory
OT  - alpha-adrenergic antagonist
EDAT- 2017/03/09 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/09 06:00
PHST- 2016/07/19 [received]
PHST- 2017/02/21 [accepted]
AID - 10.1186/s12906-017-1644-0 [doi]
AID - 10.1186/s12906-017-1644-0 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Mar 7;17(1):142. doi: 10.1186/s12906-017-1644-0.

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