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Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis.

Abstract The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individual C19MC miRNA expression in cancer and stem cells, systematic studies on C19MC miRNA expression and biological functions are lacking.
PMID
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Authors

Mayor MeshTerms
Keywords

Apoptosis

C19MC

Cancer

Stem cells

miRNA expression

Journal Title journal of biomedical science
Publication Year Start




PMID- 28270145
OWN - NLM
STAT- MEDLINE
DA  - 20170308
DCOM- 20170313
LR  - 20170313
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Mar 07
TI  - Selective activation of miRNAs of the primate-specific chromosome 19 miRNA
      cluster (C19MC) in cancer and stem cells and possible contribution to regulation 
      of apoptosis.
PG  - 20
LID - 10.1186/s12929-017-0326-z [doi]
AB  - BACKGROUND: The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a
      primate-specific miRNA cluster that may have biological significance in the
      genetic complexity of the primate. Despite previous reports on individual C19MC
      miRNA expression in cancer and stem cells, systematic studies on C19MC miRNA
      expression and biological functions are lacking. RESULTS: Cluster-wide C19MC
      miRNA expression profiling by microarray analysis showed wholesome C19MC
      activation in embryonic stem cells (ESCs) and induced pluripotent stem cells
      (iPSCs). However, in multipotent adipose-derived mesenchymal stem cells (MSCs)
      and a unipotent human white pre-adipocyte cell line, only selected C19MC miRNAs
      were expressed. MiRNA copy number analysis also showed selective C19MC expression
      in cancer cells with expression patterns highly similar to those in MSCs,
      suggesting similar miRNA regulatory mechanisms in these cells. Selective miRNA
      expression also suggests complex transcriptional mechanism(s) regulating C19MC
      expression under specific cellular and pathological conditions. Bioinformatics
      analysis showed that sixteen of the C19MC miRNAs share the same "AAGUGC" seed
      sequence with members of the miR-302/-372 family, which are known cellular
      reprogramming factors. In particular, C19MC-AAGUGC-miRNAs with the nucleotides
      2-7 canonical seed position as in miR-302/-372 miRNAs, may play similar roles as 
      miR-302/-372 in induced pluripotency. A biased 3p-arm selection of the
      C19MC-AAGUGC-miRNAs was observed indicating that targets of the 3p species of
      these miRNAs may be biologically significant in regulating stemness. Furthermore,
      bioinformatics analysis of the putative targets of the C19MC-AAGUGC-miRNAs
      predicted significant involvement of signaling pathways in reprogramming, many of
      which contribute to promoting apoptosis by indirect activation of the
      pro-apoptotic proteins BAK/BAX via suppression of genes of the cell survival
      pathways, or by enhancing caspase-8 activation through targeting inhibitors of
      TRAIL-inducing apoptosis. CONCLUSIONS: This work demonstrated selective C19MC
      expression in MSCs and cancer cells, and, through miRNA profiling and
      bioinformatics analysis, predicted C19MC modulation of apoptosis in induced
      pluripotency and tumorigenesis.
FAU - Nguyen, Phan Nguyen Nhi
AU  - Nguyen PN
AD  - Centre for Stem Cell Research, Universiti Tunku Abdul Rahman, 43000, Kajang,
      Selangor, Malaysia.
AD  - Postgraduate Program, Universiti Tunku Abdul Rahman, 43000, Kajang, Selangor,
      Malaysia.
FAU - Huang, Chiu-Jung
AU  - Huang CJ
AD  - Centre for Stem Cell Research, Universiti Tunku Abdul Rahman, 43000, Kajang,
      Selangor, Malaysia.
AD  - Department of Animal Science & Graduate Institute of Biotechnology, Chinese
      Culture University, Taipei, Taiwan.
FAU - Sugii, Shigeki
AU  - Sugii S
AD  - Singapore BioImaging Consortium, A*Star, Singapore, Singapore.
AD  - Duke-NUS Graduate Medical School, Singapore, Singapore.
FAU - Cheong, Soon Keng
AU  - Cheong SK
AD  - Centre for Stem Cell Research, Universiti Tunku Abdul Rahman, 43000, Kajang,
      Selangor, Malaysia.
AD  - Department of Preclinical Sciences, Faculty of Medicine and Health Sciences,
      Universiti Tunku Abdul Rahman, 43000, Kajang, Selangor, Malaysia.
FAU - Choo, Kong Bung
AU  - Choo KB
AUID- ORCID: http://orcid.org/0000-0002-0880-7867
AD  - Centre for Stem Cell Research, Universiti Tunku Abdul Rahman, 43000, Kajang,
      Selangor, Malaysia. [email protected]
AD  - Department of Preclinical Sciences, Faculty of Medicine and Health Sciences,
      Center for Stem Cell Research, Universiti Tunku Abdul Rahman, Sungai Long campus,
      Bandar Sungai Long, Cheras, 43000, Kajang, Selangor Darul Ehsan, Malaysia.
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170307
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Apoptosis/*genetics
MH  - Carcinogenesis/*genetics
MH  - Chromosomes, Human, Pair 19/genetics
MH  - DNA Copy Number Variations/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mesenchymal Stromal Cells/metabolism
MH  - MicroRNAs/*biosynthesis/genetics
MH  - Multigene Family
MH  - Neoplasms/*genetics
MH  - Primates/genetics
PMC - PMC5341377
OTO - NOTNLM
OT  - Apoptosis
OT  - C19MC
OT  - Cancer
OT  - Stem cells
OT  - miRNA expression
EDAT- 2017/03/09 06:00
MHDA- 2017/03/14 06:00
CRDT- 2017/03/09 06:00
PHST- 2016/11/01 [received]
PHST- 2017/02/22 [accepted]
AID - 10.1186/s12929-017-0326-z [doi]
AID - 10.1186/s12929-017-0326-z [pii]
PST - epublish
SO  - J Biomed Sci. 2017 Mar 7;24(1):20. doi: 10.1186/s12929-017-0326-z.

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