PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats.

Abstract In acupuncture practice, the most important step is to confirm the location of a sensitized acupoint which reflects a diagnosis and can be stimulated with a specialized needle to treat the disease. Abnormal symptoms such as hyperalgesia or allodynia at the sensitized acupoints in patients with visceral disorders are considered to be in relation with referred pain and neurogenic inflammation. Yet, limited study has investigated the cutaneous neurochemical changes of the sensitized acuponits.
PMID
Related Publications

Electrophysiological Characteristics of Sensitized Acupoints after Acute Intestinal Mucosal Injury in Rats.

Distribution of the activated acupoints after acute gastric mucosal injury in the rat.

Local cutaneous nerve terminal and mast cell responses to manual acupuncture in acupoint LI4 area of the rats.

Mast cell and substance P are involved in the process of acupoint sensitization induced by acute gastric mucosal injury.

Entity of acupoint: kinetic changes of acupoints in histocytochemistry.

Authors

Mayor MeshTerms

Acupuncture Points

Keywords

5-HT

Gastric mucosal injury

HA

Mast cell

Nociceptive neuropeptide

Sensitized acupoints

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28270193
OWN - NLM
STAT- MEDLINE
DA  - 20170308
DCOM- 20170314
LR  - 20170314
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 07
TI  - Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric 
      mucosal injury in rats.
PG  - 141
LID - 10.1186/s12906-017-1580-z [doi]
AB  - BACKGROUND: In acupuncture practice, the most important step is to confirm the
      location of a sensitized acupoint which reflects a diagnosis and can be
      stimulated with a specialized needle to treat the disease. Abnormal symptoms such
      as hyperalgesia or allodynia at the sensitized acupoints in patients with
      visceral disorders are considered to be in relation with referred pain and
      neurogenic inflammation. Yet, limited study has investigated the cutaneous
      neurochemical changes of the sensitized acuponits. METHODS: The resent study
      developed an animal model of gastric mucosal injury (GMI) by HCl administered
      into the stomach of the rats. Evans Blue (EB) dye was applied by injection of
      tail vein after mucosal damage to observe the neurogenic plasma extravasation
      dots in the skin of the rats. The EB dots extravagated in the skin were compared 
      with locations of acupoints. Immnohistochemistry analysis was used to detect the 
      expression of calcitonin gene-related peptide (CGRP)- or substance P (SP)-labeled
      nerve fibers, histamine (HA)-, serotonin (5-HT)-, and tryptase-labeled cells in
      EB dots. Images were recorded and analyzed by Confocal imaging system and Olympus
      Image Processing Software. RESULTS: The results showed that GMI resulted in
      neurogenic plasma extravasation in the skin of the acupoints over the back and
      abdomen, which mostly occurred in the T9-11 dermatomere. The EB extravasation
      dots appeared after GMI and disappeared gradually during the natural
      self-recovery of the gastric mucosa. More SP and CGRP positive nerve fibers were 
      distributed in EB dots than that in regions beside EB dots and in the control,
      mostly distributed in the nerve fibers around both the vessels and root of hair
      follicle. Mast cells also aggregated and degranulated to release algogenic
      substances of 5-HT and HA around the vessels in areas of the EB dots.
      CONCLUSIONS: Our results indicates that the mechanism of EB extravasation in the 
      skin of the acupoints induced by GMI are closely related to neurogenic
      inflammation, and that the high expression of local allergic substances and
      nociceptive neuropeptides in the local skin including SP, CGRP, HA, 5-HT, and
      mast cell tryptase may be the underlying mechanism of the acupoint sensitization.
FAU - He, Wei
AU  - He W
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Wang, Xiao-Yu
AU  - Wang XY
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Shi, Hong
AU  - Shi H
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Bai, Wan-Zhu
AU  - Bai WZ
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Cheng, Bin
AU  - Cheng B
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
AD  - The Affiliated Hospital, Shandong University of Traditional Chinese Medicine, No.
      42, Wenhuaxi Road, Jinan, 250014, China.
FAU - Su, Yang-Shuai
AU  - Su YS
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Yu, Xiao-Chun
AU  - Yu XC
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
FAU - Jing, Xiang-Hong
AU  - Jing XH
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
      [email protected]
FAU - Zhu, Bing
AU  - Zhu B
AD  - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
      Sciences, Nanxiaojie 16, Dongzhimennei, Beijing, 100700, China.
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170307
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Coloring Agents)
RN  - 45PG892GO1 (Evans Blue)
RN  - QTT17582CB (Hydrochloric Acid)
SB  - IM
MH  - *Acupuncture Points
MH  - Animals
MH  - Antibodies/analysis
MH  - Biomarkers/metabolism
MH  - Coloring Agents/metabolism
MH  - Disease Models, Animal
MH  - Evans Blue/metabolism
MH  - Gastric Mucosa/chemistry/metabolism
MH  - Hydrochloric Acid/pharmacology
MH  - Immunohistochemistry
MH  - Male
MH  - Neurogenic Inflammation/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stomach Diseases/chemically induced/metabolism/*therapy
PMC - PMC5341424
OTO - NOTNLM
OT  - 5-HT
OT  - Gastric mucosal injury
OT  - HA
OT  - Mast cell
OT  - Nociceptive neuropeptide
OT  - Sensitized acupoints
EDAT- 2017/03/09 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/09 06:00
PHST- 2016/09/10 [received]
PHST- 2017/01/12 [accepted]
AID - 10.1186/s12906-017-1580-z [doi]
AID - 10.1186/s12906-017-1580-z [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Mar 7;17(1):141. doi: 10.1186/s12906-017-1580-z.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>