PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model.

Abstract The cardiotoxic effect of selective cyclo-oxygenase-2 inhibitors is well known. While rofecoxib and valdecoxib have been withdrawn, celecoxib remains on the market. Folic acid, a naturally occurring vitamin, has been shown to reduce myocardial ischemia and post-reperfusion injury in rats.
PMID
Related Publications

Increased cardiac endothelin-1 and nitric oxide in adriamycin-induced acute cardiotoxicity: protective effect of Ginkgo biloba extract.

Folic acid and vitamin B(12) supplementation attenuates isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats.

Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats.

Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity.

Cardiotoxicity of doxorubicin/paclitaxel combination in rats: effect of sequence and timing of administration.

Authors

Mayor MeshTerms

Disease Models, Animal

Keywords

Selective COX-2 inhibitor

TNF-α

Tn-T

cardiovascular

Journal Title pharmaceutical biology
Publication Year Start




PMID- 28274156
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Folic acid ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure
      rat model.
PG  - 1295-1303
LID - 10.1080/13880209.2017.1299768 [doi]
AB  - CONTEXT: The cardiotoxic effect of selective cyclo-oxygenase-2 inhibitors is well
      known. While rofecoxib and valdecoxib have been withdrawn, celecoxib remains on
      the market. Folic acid, a naturally occurring vitamin, has been shown to reduce
      myocardial ischemia and post-reperfusion injury in rats. OBJECTIVE: This study
      examined the cardiac effects of celecoxib and folic acid on doxorubicin-induced
      cardiomyopathy in rats. MATERIALS AND METHODS: Cardiomyopathy was induced in male
      Wistar rats with six intraperitoneal injections of 2.5 mg/kg doxorubicin over a
      period of two weeks. The effect of 28 days of celecoxib (100 mg/kg/day) and its
      combination with folic acid (10 mg/kg/day) was studied on doxorubicin-induced
      cardiomyopathy according to serum lactate dehydrogenase (LDH), creatine kinase
      (CK-MB), troponin-T (Tn-T), tumor necrosis factor alpha (TNF-alpha), cardiac
      thiobarbituric acid reactive substance (TBARS), and glutathione (GSH) levels as
      well as systolic blood pressure (SBP), heart rate (HR) and ultrastructural
      studies. RESULTS: Celecoxib cardiotoxicity was manifested by significant
      increases in the LDH, Tn-T, TNF-alpha, CK-MB, SBP, HR (p < 0.001) and TBARS (p < 
      0.01) levels and a significant decrease in the GSH (p < 0.05) level when used
      alone or administered with doxorubicin. However, the combination of folic acid
      with celecoxib caused a significant reversal of these parameters and reduced the 
      cardiotoxicity of celecoxib that was aggravated by doxorubicin. The
      ultrastructural study also revealed myocardial protection with this combination. 
      DISCUSSION AND CONCLUSION: Folic acid protects against the cardiotoxic effects of
      celecoxib, which are aggravated in the presence of doxorubicin. Folic acid may
      act as a useful adjunct in patients who are taking celecoxib.
FAU - Ahmad, Shafique
AU  - Ahmad S
AD  - a Department of Pharmacology, Faculty of Pharmacy , Jamia Hamdard , New Delhi ,
      India.
FAU - Panda, Bibhu Prasad
AU  - Panda BP
AD  - b Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy , Jamia
      Hamdard , New Delhi , India.
FAU - Kohli, Kanchan
AU  - Kohli K
AD  - c Department of Pharmaceutics, Faculty of Pharmacy , Jamia Hamdard , New Delhi , 
      India.
FAU - Fahim, Mohammad
AU  - Fahim M
AD  - d Department of Physiology , Hamdard Institute of Medical Sciences and Research, 
      Jamia Hamdard , New Delhi , India.
FAU - Dubey, Kiran
AU  - Dubey K
AD  - a Department of Pharmacology, Faculty of Pharmacy , Jamia Hamdard , New Delhi ,
      India.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 935E97BOY8 (Folic Acid)
RN  - JCX84Q7J1L (Celecoxib)
SB  - IM
MH  - Animals
MH  - Cardiotoxicity/etiology/metabolism/*prevention & control
MH  - Celecoxib/*toxicity
MH  - *Disease Models, Animal
MH  - Folic Acid/*therapeutic use
MH  - Heart Failure/*chemically induced/metabolism/*prevention & control
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Selective COX-2 inhibitor
OT  - TNF-alpha
OT  - Tn-T
OT  - cardiovascular
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.1080/13880209.2017.1299768 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1295-1303. doi: 10.1080/13880209.2017.1299768.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>