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PMID- 28274159
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Effect of Spirulina platensis ingestion on the abnormal biochemical and oxidative
      stress parameters in the pancreas and liver of alloxan-induced diabetic rats.
PG  - 1304-1312
LID - 10.1080/13880209.2017.1300820 [doi]
AB  - CONTEXT: Previous studies have shown that Spirulina platensis Gomont
      (Phormidiaceae) (SP) extract has beneficial effects on many disease conditions.
      The putative protective effects of SP were investigated in diabetic rats.
      OBJECTIVE: The current study investigates the antioxidant effects of SP in
      diabetic Wistar rats. MATERIALS AND METHODS: Alloxan monohydrate (150 mg/kg body 
      weight) was intraperitoneally administrated to induce diabetes. An aqueous
      suspension of SP powder in distillate water (10% w/v) was administrated orally by
      gavage (1 mL/day) for 50 days. Histopathological, biochemical and antioxidant
      analyses were performed. Glycemia, liver function and HOMA-IR were assessed using
      Spinreact and ELISA kits. RESULTS: SP exhibited high-antioxidant activity. The
      IC50 values of the SP aqueous extract were 70.40 and 45.69 mg/L compared to those
      of the standard antioxidant BHT, which were 27.97 and 19.77 mg/L, for the DPPH
      and ABTS tests, respectively. The diabetic animals showed a significant increase 
      in glycaemia (from 4.05 to 4.28 g/L) and thiobarbituric acid reactive substances 
      (50.17 mmol/g protein) levels. Treatment with SP significantly reduced glycaemia 
      by 79% and liver function markers [glutamate pyruvate transaminase (GPT),
      glutamate oxaloacetate transaminase (GOT) and alkaline phosphatase (Alk-p)]) by
      25, 36 and 20%, respectively, compared to that of the controls. There was a
      significant increase in superoxide dismutase (48%), total antioxidant status
      (43%), glutathione peroxidase (37%) and glutathione reductase (16%) in the
      diabetic rats treated with SP. DISCUSSION AND CONCLUSION: These results showed
      that SP has high antioxidant activity, free radical scavenging, antihyperglycemic
      and hepatoprotective effects in diabetes.
FAU - Aissaoui, Ourida
AU  - Aissaoui O
AD  - a Food Technology and Human Nutrition Laboratory , Ecole Nationale Superieure
      Agronomique (ENSA) , Algiers , Algeria.
FAU - Amiali, Malek
AU  - Amiali M
AD  - a Food Technology and Human Nutrition Laboratory , Ecole Nationale Superieure
      Agronomique (ENSA) , Algiers , Algeria.
FAU - Bouzid, Nora
AU  - Bouzid N
AD  - b Department of Anapathology , CHU Parnet , Algiers , Algeria.
FAU - Belkacemi, Khaled
AU  - Belkacemi K
AD  - c Department of Soil Sciences and Agri-Food Engineering , Universite Laval ,
      Quebec City , Quebec , Canada.
FAU - Bitam, Arezki
AU  - Bitam A
AD  - a Food Technology and Human Nutrition Laboratory , Ecole Nationale Superieure
      Agronomique (ENSA) , Algiers , Algeria.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Antioxidants)
RN  - 6SW5YHA5NG (Alloxan)
SB  - IM
MH  - Alloxan
MH  - Animals
MH  - Antioxidants/isolation & purification/pharmacology/*therapeutic use
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Oxidative Stress/*drug effects/physiology
MH  - Pancreas/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - *Spirulina
OT  - Antioxidant effect
OT  - beta-cells
OT  - glycaemia
OT  - liver function
OT  - metformin
OT  - organ weight
OT  - phenolic compounds
OT  - phycobiliproteins
OT  - weight gain
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.1080/13880209.2017.1300820 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1304-1312. doi: 10.1080/13880209.2017.1300820.

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