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Protective effects of Cassia tora leaves in experimental cataract by modulating intracellular communication, membrane co-transporters, energy metabolism and the ubiquitin-proteasome pathway.

Abstract Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpinaceae) is an edible plant mentioned in the traditional systems of medicine for whole body health, especially to the eyes.
PMID
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Authors

Mayor MeshTerms

Cassia

Symporters

Keywords

Blindness

functional food

oxidative stress

selenite cataract

Journal Title pharmaceutical biology
Publication Year Start




PMID- 28274170
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 55
IP  - 1
DP  - 2017 Dec
TI  - Protective effects of Cassia tora leaves in experimental cataract by modulating
      intracellular communication, membrane co-transporters, energy metabolism and the 
      ubiquitin-proteasome pathway.
PG  - 1274-1282
LID - 10.1080/13880209.2017.1299769 [doi]
AB  - CONTEXT: Cataract is the clouding of eye lens which causes impairment in vision
      and accounts for the leading factor of global blindness. Functional food-based
      prevention of cataract finds application in vision research because of its
      availability and easy access to all classes of the society. Cassia tora Linn.
      (Caesalpinaceae) is an edible plant mentioned in the traditional systems of
      medicine for whole body health, especially to the eyes. OBJECTIVE: The present
      study evaluates the potential of ethyl acetate fraction of Cassia tora leaves
      (ECT) on experimental cataract. MATERIALS AND METHODS: Cataract was induced by a 
      single subcutaneous injection of sodium selenite (4 mug/g body weight) on 10th
      day. ECT was supplemented orally from 8th day up to 12th day at a concentration
      of 5 mug/g body weight and marker parameters were evaluated after 30 days.
      RESULTS: The production of MPO and the activation of calpain were reduced 52.17% 
      and 36.67% by ECT in lens tissue, respectively. It modulated the energy status by
      significantly increasing the activity of CCO 1 (55.56%) and ATP production
      (41.88%). ECT maintained the ionic balance in the lens by reducing the level of
      sodium (50%) and increasing the level of potassium (42.5%). It also reduced cell 
      junction modifications and preserved a functional ubiquitin-proteasome pathway.
      DISCUSSION AND CONCLUSION: The results reinforce the growing attention on wild
      plant food resources for preventive protection against cataract. The data suggest
      the value of Cassia tora leaves as a functional food for ameliorating cataract
      pathology.
FAU - Sreelakshmi, V
AU  - Sreelakshmi V
AD  - a Department of Biochemistry , University of Kerala , Thiruvananthapuram , Kerala
      , India.
FAU - Abraham, Annie
AU  - Abraham A
AD  - a Department of Biochemistry , University of Kerala , Thiruvananthapuram , Kerala
      , India.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Plant Extracts)
RN  - 0 (Protective Agents)
RN  - 0 (Symporters)
RN  - 0 (Ubiquitin)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Animals
MH  - *Cassia
MH  - Cataract/*drug therapy/metabolism
MH  - Cell Communication/*drug effects/physiology
MH  - Cell Membrane/drug effects/metabolism
MH  - Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Energy Metabolism/*drug effects/physiology
MH  - Intracellular Fluid/drug effects/metabolism
MH  - Oxidative Stress/drug effects/physiology
MH  - Plant Extracts/isolation & purification/pharmacology/*therapeutic use
MH  - Plant Leaves
MH  - Proteasome Endopeptidase Complex/metabolism
MH  - Protective Agents/isolation & purification/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/drug effects/physiology
MH  - *Symporters/metabolism
MH  - Treatment Outcome
MH  - Ubiquitin/metabolism
OTO - NOTNLM
OT  - Blindness
OT  - functional food
OT  - oxidative stress
OT  - selenite cataract
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.1080/13880209.2017.1299769 [doi]
PST - ppublish
SO  - Pharm Biol. 2017 Dec;55(1):1274-1282. doi: 10.1080/13880209.2017.1299769.

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