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Out of the blue finger ischaemia and occult colorectal cancer.

Abstract A woman aged 66 years with a history of unprovoked deep venous thrombosis (DVT) presented with persistent digital ischaemic changes of 2 of her right hand fingers. Physical examination was otherwise normal and extensive laboratory and imaging studies were unremarkable. A history of unprovoked DVT and the current episode of digital ischaemia prompted concern for underlying occult malignancy. Repeated history-taking revealed a strongly positive family history suggesting an occult colorectal cancer. Colonoscopy with biopsy revealed adenocarcinoma. Adenocarcinoma of the colon has rarely been associated with paraneoplastic acral vascular syndrome. This report suggests that occult malignancy needs to be considered in patients with focal digital ischaemia as this association is poorly unrecognised.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title bmj case reports
Publication Year Start




PMID- 28275022
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2017
DP  - 2017 Mar 08
TI  - Out of the blue finger ischaemia and occult colorectal cancer.
LID - bcr2016218779 [pii]
LID - 10.1136/bcr-2016-218779 [doi]
AB  - A woman aged 66 years with a history of unprovoked deep venous thrombosis (DVT)
      presented with persistent digital ischaemic changes of 2 of her right hand
      fingers. Physical examination was otherwise normal and extensive laboratory and
      imaging studies were unremarkable. A history of unprovoked DVT and the current
      episode of digital ischaemia prompted concern for underlying occult malignancy.
      Repeated history-taking revealed a strongly positive family history suggesting an
      occult colorectal cancer. Colonoscopy with biopsy revealed adenocarcinoma.
      Adenocarcinoma of the colon has rarely been associated with paraneoplastic acral 
      vascular syndrome. This report suggests that occult malignancy needs to be
      considered in patients with focal digital ischaemia as this association is poorly
      unrecognised.
CI  - 2017 BMJ Publishing Group Ltd.
FAU - Schattner, Ami
AU  - Schattner A
AD  - Hebrew University Faculty of Medicine, Jerusalem, Israel.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170308
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Adenocarcinoma/*diagnosis/drug therapy/surgery
MH  - Aged
MH  - Antineoplastic Agents/administration & dosage/therapeutic use
MH  - Colonoscopy
MH  - Colorectal Neoplasms/*diagnosis/drug therapy/surgery
MH  - Female
MH  - Fingers/*blood supply
MH  - Humans
MH  - Ischemia/*etiology
MH  - Treatment Outcome
MH  - Venous Thrombosis/*complications
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - bcr-2016-218779 [pii]
AID - 10.1136/bcr-2016-218779 [doi]
PST - epublish
SO  - BMJ Case Rep. 2017 Mar 8;2017. pii: bcr2016218779. doi: 10.1136/bcr-2016-218779.

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