PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer Cells.

Abstract Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription factor family. Increasing evidence has reported that SOX9 plays different roles in various types of malignancies. However, the role of SOX9 in papillary thyroid cancer (PTC) is still unclear. The aim of this study was to investigate the role of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and cell lines. In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial-mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells. Moreover, knockdown of SOX9 significantly inhibited the expression levels of β-catenin, cyclin D1, and c-Myc in PTC cells. In conclusion, this is the first report demonstrating that knockdown of SOX9 inhibited PTC cell proliferation, invasion, and the EMT process via suppressing Wnt/β-catenin signaling pathway. Thus, SOX9 may act as a novel molecular target for the prevention and treatment of PTC.
PMID
Related Publications

LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-κB activation in papillary thyroid carcinoma.

LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.

Twist1 regulates the epithelial-mesenchymal transition via the NF-κB pathway in papillary thyroid carcinoma.

MicroRNA-663 suppresses cell invasion and migration by targeting transforming growth factor beta 1 in papillary thyroid carcinoma.

ABCG2/BCRP gene expression is related to epithelial-mesenchymal transition inducer genes in a papillary thyroid carcinoma cell line (TPC-1).

Authors

Mayor MeshTerms

Gene Knockdown Techniques

Keywords
Journal Title oncology research
Publication Year Start




PMID- 28277188
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Linking)
VI  - 25
IP  - 2
DP  - 2017 Jan 26
TI  - Knockdown of SOX9 Inhibits the Proliferation, Invasion, and EMT in Thyroid Cancer
      Cells.
PG  - 167-176
LID - 10.3727/096504016X14732772150307 [doi]
AB  - Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription 
      factor family. Increasing evidence has reported that SOX9 plays different roles
      in various types of malignancies. However, the role of SOX9 in papillary thyroid 
      cancer (PTC) is still unclear. The aim of this study was to investigate the role 
      of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and
      cell lines. In addition, knockdown of SOX9 significantly inhibited PTC
      proliferation, colony formation, migration, and invasion, as well as
      epithelial-mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells.
      Moreover, knockdown of SOX9 significantly inhibited the expression levels of
      beta-catenin, cyclin D1, and c-Myc in PTC cells. In conclusion, this is the first
      report demonstrating that knockdown of SOX9 inhibited PTC cell proliferation,
      invasion, and the EMT process via suppressing Wnt/beta-catenin signaling pathway.
      Thus, SOX9 may act as a novel molecular target for the prevention and treatment
      of PTC.
FAU - Huang, Jie
AU  - Huang J
AD  - Department of General Surgery, Weifang People's Hospital, Weifang, P.R. China.
FAU - Guo, Li
AU  - Guo L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - 0 (SOX9 Transcription Factor)
RN  - 0 (SOX9 protein, human)
RN  - Thyroid cancer, papillary
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Carcinoma/*genetics/*pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*genetics
MH  - Epithelial-Mesenchymal Transition/*genetics
MH  - Female
MH  - *Gene Knockdown Techniques/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - SOX9 Transcription Factor/*genetics
MH  - Thyroid Neoplasms/*genetics/*pathology
MH  - Young Adult
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.3727/096504016X14732772150307 [doi]
PST - ppublish
SO  - Oncol Res. 2017 Jan 26;25(2):167-176. doi: 10.3727/096504016X14732772150307.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>