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miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R.

Abstract Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human glioma. We found that miR-422a was downregulated in glioma tissues. We also demonstrated that expression of miR-422a in glioma cells markedly suppressed cell proliferation, migration, and invasion. In addition, we identified insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) as inhibitory targets of miR-422a in glioma cells. We established that the expression levels of miR-422a were negatively correlated with the expression levels of IGF1/IGF1R and the clinical parameters in glioma patients. An IGFR inhibitor, AG1024, completely blocked the activity of miR-442a on glioma cell proliferation and invasion, which further confirmed that miR-422a functions through IGF1 and IGF1R.
PMID
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Authors

Mayor MeshTerms

Gene Targeting

Keywords
Journal Title oncology research
Publication Year Start




PMID- 28277190
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Linking)
VI  - 25
IP  - 2
DP  - 2017 Jan 26
TI  - miR-422a Inhibits Glioma Proliferation and Invasion by Targeting IGF1 and IGF1R.
PG  - 187-194
LID - 10.3727/096504016X14732772150389 [doi]
AB  - Glioma is a common type of malignant brain tumor characterized by aggressive
      metastasis capability. Recent evidence has suggested that noncoding RNAs,
      including microRNAs, have important functions in the pathophysiology of glioma
      development. In this study, we investigated the biological function of miR-422a
      in human glioma. We found that miR-422a was downregulated in glioma tissues. We
      also demonstrated that expression of miR-422a in glioma cells markedly suppressed
      cell proliferation, migration, and invasion. In addition, we identified
      insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) as inhibitory
      targets of miR-422a in glioma cells. We established that the expression levels of
      miR-422a were negatively correlated with the expression levels of IGF1/IGF1R and 
      the clinical parameters in glioma patients. An IGFR inhibitor, AG1024, completely
      blocked the activity of miR-442a on glioma cell proliferation and invasion, which
      further confirmed that miR-422a functions through IGF1 and IGF1R.
FAU - Wang, Haiyang
AU  - Wang H
AD  - Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical
      University, Harbin, P.R. China.
FAU - Tang, Chongyang
AU  - Tang C
FAU - Na, Meng
AU  - Na M
FAU - Ma, Wei
AU  - Ma W
FAU - Jiang, Zhenfeng
AU  - Jiang Z
FAU - Gu, Yifei
AU  - Gu Y
FAU - Ma, Guizhen
AU  - Ma G
FAU - Ge, Haitao
AU  - Ge H
FAU - Shen, Hong
AU  - Shen H
FAU - Lin, Zhiguo
AU  - Lin Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - 0 (IGF1 protein, human)
RN  - 0 (IGF1R protein, human)
RN  - 0 (MIRN422 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Receptors, Somatomedin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Brain Neoplasms/genetics/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/genetics
MH  - *Gene Targeting/methods
MH  - Glioma/genetics/*metabolism/pathology
MH  - Humans
MH  - Insulin-Like Growth Factor I/antagonists & inhibitors/*biosynthesis/genetics
MH  - MicroRNAs/*biosynthesis/genetics
MH  - Neoplasm Invasiveness/genetics/pathology
MH  - Receptors, Somatomedin/antagonists & inhibitors/*biosynthesis/genetics
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.3727/096504016X14732772150389 [doi]
PST - ppublish
SO  - Oncol Res. 2017 Jan 26;25(2):187-194. doi: 10.3727/096504016X14732772150389.

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