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Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.

Abstract Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found that the Gli1 inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title oncology research
Publication Year Start




PMID- 28277196
OWN - NLM
STAT- MEDLINE
DA  - 20170309
DCOM- 20170316
LR  - 20170316
IS  - 1555-3906 (Electronic)
IS  - 0965-0407 (Linking)
VI  - 25
IP  - 2
DP  - 2017 Jan 26
TI  - Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In 
      Vivo.
PG  - 241-248
LID - 10.3727/096504016X14742891049118 [doi]
AB  - Rab23, a novel member of the Rab GTPase family, was found to be implicated in the
      progression of some human cancers. However, what role Rab23 plays in prostate
      cancer (PCa) remains to be illustrated. In the present study, we investigated the
      expression pattern and roles of Rab23 in PCa. The study results showed that Rab23
      was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 
      remarkably suppressed the proliferation, migration, and invasion of PCa cells. In
      addition, downregulation of Rab23 significantly downregulated the protein
      expression levels of Shh and Gli1. Furthermore, we found that the Gli1 inhibitor 
      GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa
      cells. In conclusion, we suggested Rab23 as a potential therapeutic target for
      PCa treatment.
FAU - Chang, Junkai
AU  - Chang J
AD  - Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan
      Province, P.R. China.
FAU - Xu, Weibo
AU  - Xu W
FAU - Liu, Guangchao
AU  - Liu G
FAU - Du, Xinyi
AU  - Du X
FAU - Li, Xiaodong
AU  - Li X
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncol Res
JT  - Oncology research
JID - 9208097
RN  - EC 3.6.1.- (RAB23 protein, human)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/genetics/*metabolism/pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/physiology
MH  - Down-Regulation/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Prostatic Neoplasms/genetics/*metabolism/pathology
MH  - Random Allocation
MH  - Xenograft Model Antitumor Assays/methods
MH  - rab GTP-Binding Proteins/genetics/*metabolism
EDAT- 2017/03/10 06:00
MHDA- 2017/03/17 06:00
CRDT- 2017/03/10 06:00
AID - 10.3727/096504016X14742891049118 [doi]
PST - ppublish
SO  - Oncol Res. 2017 Jan 26;25(2):241-248. doi: 10.3727/096504016X14742891049118.

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