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Multiple chemical sensitivity: Genotypic characterization, nutritional status and quality of life in 52 patients.

Abstract Multiple chemical sensitivity (MCS) is a chronic, multisystem syndrome of unknown etiology. The aim of the present study was to describe the nutritional status and quality of life of patients suffering from MCS, as well as to identify potential polymorphisms associated with this illness.
PMID
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Authors

Mayor MeshTerms

Genotype

Multiple Chemical Sensitivity

Nutritional Status

Polymorphism, Single Nucleotide

Quality of Life

Keywords

Calidad de vida

Genetic polymorphisms

Malnutrición

Malnutrition

Multiple chemical sensitivity

Polimorfismos genéticos

Quality of life

Sensibilidad química múltiple

Journal Title medicina clinica
Publication Year Start




PMID- 28283271
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20180522
IS  - 1578-8989 (Electronic)
IS  - 0025-7753 (Linking)
VI  - 149
IP  - 4
DP  - 2017 Aug 22
TI  - Multiple chemical sensitivity: Genotypic characterization, nutritional status and
      quality of life in 52 patients.
PG  - 141-146
LID - S0025-7753(17)30093-3 [pii]
LID - 10.1016/j.medcli.2017.01.022 [doi]
AB  - BACKGROUND AND OBJECTIVES: Multiple chemical sensitivity (MCS) is a chronic,
      multisystem syndrome of unknown etiology. The aim of the present study was to
      describe the nutritional status and quality of life of patients suffering from
      MCS, as well as to identify potential polymorphisms associated with this illness.
      PATIENTS AND METHODS: A cross-sectional, descriptive study was performed on
      patients with a diagnosis of MCS. Data on anthropometric and body composition
      variables, hand muscle strength and quality of life were collected. The selection
      of single nucleotide polymorphisms (SNPs) was based on genes previously
      associated with MCS and genes involved in inflammatory and oxidative stress
      pathways. RESULTS: A total of 52 patients (93.2% female), with a mean age of 50.9
      (10.3) years were included in the study. Among them, based on their BMI, 48% had 
      an inadequate nutritional status (17% were underweight and 32% were overweight or
      obese). Thirty percent of patients had a low muscle mass for their age, 84% had
      muscle strength below the tenth percentile, and 51.8% had a high fat mass
      percentage. Regarding quality of life, all median scores were lower than those of
      other illnesses assessed for every subscale assessed. Statistically significant
      differences between patient cases and controls were found with respect to
      rs1801133 (MTHFR), rs174546 (FADS1) and rs1801282 (PPARgamma) polymorphisms.
      CONCLUSION: A high percentage of patients had a poor nutritional status, low
      muscle strength and decreased muscle mass. These facts exacerbate the
      already-lower quality of life of these patients. Specific genetic polymorphisms
      associated with the syndrome or its pathogenesis were not identified.
CI  - Copyright (c) 2017 Elsevier Espana, S.L.U. All rights reserved.
FAU - Loria-Kohen, Viviana
AU  - Loria-Kohen V
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
      Electronic address: [email protected]
FAU - Marcos-Pasero, Helena
AU  - Marcos-Pasero H
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - de la Iglesia, Rocio
AU  - de la Iglesia R
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - Aguilar-Aguilar, Elena
AU  - Aguilar-Aguilar E
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - Espinosa-Salinas, Isabel
AU  - Espinosa-Salinas I
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - Herranz, Jesus
AU  - Herranz J
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - Ramirez de Molina, Ana
AU  - Ramirez de Molina A
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana.
FAU - Reglero, Guillermo
AU  - Reglero G
AD  - IMDEA-Food, Campus de Excelencia Internacional (CEI) UAM+CSIC, Madrid, Espana;
      Departamento de Produccion y Caracterizacion de Nuevos Alimentos, Instituto de
      Investigacion en Ciencias de la Alimentacion (CIAL), Campus de Excelencia
      Internacional (CEI) UAM+CSIC, Madrid, Espana.
LA  - eng
LA  - spa
PT  - Journal Article
TT  - Sensibilidad quimica multiple: caracterizacion genotipica, estado nutricional y
      calidad de vida de 52 pacientes.
DEP - 20170307
PL  - Spain
TA  - Med Clin (Barc)
JT  - Medicina clinica
JID - 0376377
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Body Composition
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Markers
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - Hand Strength
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Multiple Chemical Sensitivity/complications/diagnosis/genetics/physiopathology
MH  - *Nutritional Status
MH  - Overweight/diagnosis/epidemiology/*etiology
MH  - *Polymorphism, Single Nucleotide
MH  - *Quality of Life
MH  - Thinness/diagnosis/epidemiology/*etiology
OTO - NOTNLM
OT  - Calidad de vida
OT  - Genetic polymorphisms
OT  - Malnutricion
OT  - Malnutrition
OT  - Multiple chemical sensitivity
OT  - Polimorfismos geneticos
OT  - Quality of life
OT  - Sensibilidad quimica multiple
EDAT- 2017/03/12 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/03/12 06:00
PHST- 2016/08/22 00:00 [received]
PHST- 2016/11/21 00:00 [revised]
PHST- 2017/01/17 00:00 [accepted]
PHST- 2017/03/12 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/03/12 06:00 [entrez]
AID - S0025-7753(17)30093-3 [pii]
AID - 10.1016/j.medcli.2017.01.022 [doi]
PST - ppublish
SO  - Med Clin (Barc). 2017 Aug 22;149(4):141-146. doi: 10.1016/j.medcli.2017.01.022.
      Epub 2017 Mar 7.