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The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population.

Abstract CXCL16 has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of the CXCL16 polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1.03-1.66, and P = 0.029) and CC genotype (OR = 1.84, 95% CI = 1.11-3.06, and P = 0.018) of rs1050998 were associated with increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60-0.98, and P = 0.036) of rs8123 exhibited decreased MI risk, while the other two tagSNPs had no significant effect. Consistently, the haplotype rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02-1.96, and P = 0.037). Further stratified analysis unveiled a more apparent association with MI risk among younger subjects (≤60 years old). Taken together, our results provided the first evidence that CXCL16 polymorphisms significantly impacted MI risk in Chinese subjects.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title disease markers
Publication Year Start




PMID- 28286356
OWN - NLM
STAT- MEDLINE
DA  - 20170313
DCOM- 20170314
LR  - 20170315
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 2017
DP  - 2017
TI  - The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a
      Chinese Han Population.
PG  - 9463272
LID - 10.1155/2017/9463272 [doi]
AB  - CXCL16 has been demonstrated to be involved in the development of atherosclerosis
      and myocardial infarction (MI). Nonetheless, the role of the CXCL16 polymorphisms
      on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in
      CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 
      670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on
      individual susceptibility to MI. Multivariate logistic regression analysis showed
      that C allele (OR = 1.31, 95% CI = 1.03-1.66, and P = 0.029) and CC genotype (OR 
      = 1.84, 95% CI = 1.11-3.06, and P = 0.018) of rs1050998 were associated with
      increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60-0.98, and P = 0.036) of
      rs8123 exhibited decreased MI risk, while the other two tagSNPs had no
      significant effect. Consistently, the haplotype
      rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and
      A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02-1.96, and
      P = 0.037). Further stratified analysis unveiled a more apparent association with
      MI risk among younger subjects (</=60 years old). Taken together, our results
      provided the first evidence that CXCL16 polymorphisms significantly impacted MI
      risk in Chinese subjects.
FAU - Xu, Shun
AU  - Xu S
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Institute of Biochemistry & Molecular
      Biology, Guangdong Medical University, Zhanjiang, China.
FAU - Cheng, Jie
AU  - Cheng J
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Department of Clinical Laboratory, The
      Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
FAU - Cai, Meng-Yun
AU  - Cai MY
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Institute of Biochemistry & Molecular
      Biology, Guangdong Medical University, Zhanjiang, China.
FAU - Liang, Li-Li
AU  - Liang LL
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Institute of Biochemistry & Molecular
      Biology, Guangdong Medical University, Zhanjiang, China.
FAU - Cen, Jin-Ming
AU  - Cen JM
AD  - Department of Cardiovascular Disease, The First People's Hospital of Foshan,
      Foshan, China.
FAU - Yang, Xi-Li
AU  - Yang XL
AD  - Department of Cardiovascular Disease, The First People's Hospital of Foshan,
      Foshan, China.
FAU - Chen, Can
AU  - Chen C
AD  - Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong
      Medical University, Zhanjiang, China.
FAU - Liu, Xinguang
AU  - Liu X
AUID- ORCID: 0000-0001-6963-1386
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Institute of Biochemistry & Molecular
      Biology, Guangdong Medical University, Zhanjiang, China.
FAU - Xiong, Xing-Dong
AU  - Xiong XD
AUID- ORCID: 0000-0003-4956-0917
AD  - Institute of Aging Research, Guangdong Medical University, Dongguan, China;
      Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong
      Medical University, Dongguan, China; Institute of Biochemistry & Molecular
      Biology, Guangdong Medical University, Zhanjiang, China.
LA  - eng
PT  - Journal Article
DEP - 20170214
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (CXCL16 protein, human)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, Scavenger)
SB  - IM
MH  - Aged
MH  - Asian Continental Ancestry Group/genetics
MH  - Case-Control Studies
MH  - Chemokines, CXC/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Scavenger/*genetics
PMC - PMC5329692
COI - The authors declare no conflict of interests.
EDAT- 2017/03/14 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/14 06:00
PHST- 2016/09/13 [received]
PHST- 2016/12/25 [revised]
PHST- 2017/01/22 [accepted]
AID - 10.1155/2017/9463272 [doi]
PST - ppublish
SO  - Dis Markers. 2017;2017:9463272. doi: 10.1155/2017/9463272. Epub 2017 Feb 14.

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