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Cell-Based Models for Development of Antiatherosclerotic Therapies.

Abstract The leading cause of death worldwide is cardiovascular disease. Among the conditions related to the term, the most prominent one is the development of atherosclerotic plaques in the walls of arteries. The situation gets even worse with the fact that the plaque development may stay asymptomatic for a prolonged period of time. When it manifests as a cardiovascular disorder, it is already too late: the unfortunate individual is prescribed with a plethora of synthetic drugs, which are of debatable efficacy in the prevention of atherosclerotic lesions and safety. Cell models could be useful for the purpose of screening substances potentially effective against atherosclerosis progression and effective in reduction of already present plaques. In this overview, we present studies making use of in vitro and ex vivo models of atherosclerosis development that can prove valuable for clinical applications.
PMID
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Authors

Mayor MeshTerms

Models, Biological

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28286766
OWN - NLM
STAT- MEDLINE
DA  - 20170313
DCOM- 20170317
LR  - 20170317
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Cell-Based Models for Development of Antiatherosclerotic Therapies.
PG  - 5198723
LID - 10.1155/2017/5198723 [doi]
AB  - The leading cause of death worldwide is cardiovascular disease. Among the
      conditions related to the term, the most prominent one is the development of
      atherosclerotic plaques in the walls of arteries. The situation gets even worse
      with the fact that the plaque development may stay asymptomatic for a prolonged
      period of time. When it manifests as a cardiovascular disorder, it is already too
      late: the unfortunate individual is prescribed with a plethora of synthetic
      drugs, which are of debatable efficacy in the prevention of atherosclerotic
      lesions and safety. Cell models could be useful for the purpose of screening
      substances potentially effective against atherosclerosis progression and
      effective in reduction of already present plaques. In this overview, we present
      studies making use of in vitro and ex vivo models of atherosclerosis development 
      that can prove valuable for clinical applications.
FAU - Zakiev, Emile R
AU  - Zakiev ER
AUID- ORCID: 0000-0002-3811-3399
AD  - Institute of General Pathology and Pathophysiology, Moscow, Russia; INSERM UMR_S 
      1166-ICAN Faculte de Medecine Pitie-Salpetriere, Paris, France.
FAU - Nikiforov, Nikita G
AU  - Nikiforov NG
AUID- ORCID: 0000-0002-2082-2429
AD  - Institute of General Pathology and Pathophysiology, Moscow, Russia.
FAU - Orekhov, Alexander N
AU  - Orekhov AN
AUID- ORCID: 0000-0002-6495-1628
AD  - Institute of General Pathology and Pathophysiology, Moscow, Russia; Institute for
      Atherosclerosis Research, Skolkovo Innovation Center, Moscow, Russia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170214
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*metabolism/pathology/*therapy
MH  - Humans
MH  - *Models, Biological
MH  - Plaque, Atherosclerotic/*metabolism/pathology/*therapy
PMC - PMC5329658
COI - The authors declare that there are no competing interests.
EDAT- 2017/03/14 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/14 06:00
PHST- 2016/10/09 [received]
PHST- 2017/01/11 [accepted]
AID - 10.1155/2017/5198723 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:5198723. doi: 10.1155/2017/5198723. Epub 2017 Feb 14.

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