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Implication of overexpression of dishevelled-associated activator of morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary Arterial Hypertension (IPAH).

Abstract Idiopathic pulmonary arterial hypertension (IPAH) is a rare, fatal disease of unknown pathogenesis. Evidence from our recent study suggests that IPAH pathogenesis is related to upregulation of the Wnt/planar cell polarity (Wnt/PCP) pathway. We used microscopic observation and immunohistochemical techniques to identify expression patterns of cascading proteins-namely Wnt-11, dishevelled-2 (Dvl-2), and dishevelled-associated activator of morphogenesis 1 (Daam-1)-in pulmonary arteries.
PMID
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Authors

Mayor MeshTerms
Keywords

Daam-1

IPAH

Overexpression

Smooth muscle cells

Wnt/PCP pathway

Journal Title diagnostic pathology
Publication Year Start




PMID- 28288669
OWN - NLM
STAT- MEDLINE
DA  - 20170314
DCOM- 20170317
LR  - 20170319
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Mar 14
TI  - Implication of overexpression of dishevelled-associated activator of
      morphogenesis 1 (Daam-1) for the pathogenesis of human Idiopathic Pulmonary
      Arterial Hypertension (IPAH).
PG  - 25
LID - 10.1186/s13000-017-0614-7 [doi]
AB  - BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is a rare, fatal
      disease of unknown pathogenesis. Evidence from our recent study suggests that
      IPAH pathogenesis is related to upregulation of the Wnt/planar cell polarity
      (Wnt/PCP) pathway. We used microscopic observation and immunohistochemical
      techniques to identify expression patterns of cascading proteins-namely Wnt-11,
      dishevelled-2 (Dvl-2), and dishevelled-associated activator of morphogenesis 1
      (Daam-1)-in pulmonary arteries. METHODS: We analyzed sections of formalin-fixed
      and paraffin-embedded autopsied lung tissues obtained from 9 IPAH cases, 7
      associated pulmonary arterial hypertension cases, and 16 age-matched controls
      without pulmonary arterial abnormalities. Results of microscopic observation were
      analyzed in relation to the cellular components and size of pulmonary arteries.
      RESULTS: Varying rates of positive reactivity to Dvl-2 and Daam-1 were confirmed 
      in all cellular components of pulmonary arteries, namely, endothelial cells,
      myofibroblasts, and medial smooth muscle cells. In contrast, none of these
      components was reactive to Wnt-11. No specific expression patterns were observed 
      for endothelial cells or myofibroblasts under any experimental conditions.
      However, marked expression of Dvl-2 and Daam-1 was confirmed in smooth muscle
      cells. In addition, Dvl-2 was depleted while Daam-1 expression was elevated in
      IPAH, in contrast with specimens from associated pulmonary arterial hypertension 
      cases and controls. CONCLUSIONS: High Daam-1 expression may upregulate the
      Wnt/PCP pathway and cause IPAH.
FAU - Yanai, Shun
AU  - Yanai S
AD  - Department of Pediatrics, Toho University School of Medicine, 6-11-1 Omori-nishi,
      Ota-ku, Tokyo, 143-8541, Japan.
FAU - Wakayama, Megumi
AU  - Wakayama M
AD  - Department of Surgical Pathology, Toho University School of Medicine, 6-11-1
      Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan. [email protected]
FAU - Nakayama, Haruo
AU  - Nakayama H
AD  - Department of Neurosurgery, Toho University Ohashi Medical Center, 2-17-6 Ohashi,
      Meguro-ku, Tokyo, 153-8515, Japan.
FAU - Shinozaki, Minoru
AU  - Shinozaki M
AD  - Department of Surgical Pathology, Toho University School of Medicine, 6-11-1
      Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
FAU - Tsukuma, Hisayuki
AU  - Tsukuma H
AD  - Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540,
      Japan.
FAU - Tochigi, Naobumi
AU  - Tochigi N
AD  - Department of Surgical Pathology, Toho University School of Medicine, 6-11-1
      Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
FAU - Nemoto, Tetsuo
AU  - Nemoto T
AD  - Department of Surgical Pathology, Toho University School of Medicine, 6-11-1
      Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
FAU - Saji, Tsutomu
AU  - Saji T
AD  - Advanced and Integrated Cardiovascular Research Course in the Young and
      Adolescence, Toho University School of Medicine, 5-21-16 Omori-nishi, Ota-ku,
      Tokyo, 143-8540, Japan.
FAU - Shibuya, Kazutoshi
AU  - Shibuya K
AD  - Department of Surgical Pathology, Toho University School of Medicine, 6-11-1
      Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DAAM1 protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*biosynthesis
MH  - Adolescent
MH  - Adult
MH  - Familial Primary Pulmonary Hypertension/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Up-Regulation
MH  - Wnt Signaling Pathway/*physiology
MH  - Young Adult
PMC - PMC5348773
OTO - NOTNLM
OT  - Daam-1
OT  - IPAH
OT  - Overexpression
OT  - Smooth muscle cells
OT  - Wnt/PCP pathway
EDAT- 2017/03/16 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/03/15 06:00
PHST- 2016/11/14 [received]
PHST- 2017/02/20 [accepted]
AID - 10.1186/s13000-017-0614-7 [doi]
AID - 10.1186/s13000-017-0614-7 [pii]
PST - epublish
SO  - Diagn Pathol. 2017 Mar 14;12(1):25. doi: 10.1186/s13000-017-0614-7.

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