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Acute organophosphorus intoxications in pregnant women.

Abstract Acute organophosphorus pesticides (OPs) poisoning during pregnancy are rare events, not well documented in the literature. We conducted a retrospective analysis of outcomes in seven cases of suicidal ingestion of OP in pregnant women. This intoxication was most often serious. Indeed, five of seven parturients had an initial Glasgow score < 9 and the POP score was ≥ 3 in all parturients. Five patients required mechanical ventilation for a mean duration of 3,4 days. All patients reported favorable outcomes but in more than half of the cases fetuses had unfavorable outcomes (fetal death in utero). Two mechanisms can explain these fetal complications. The first mechanism is fetal hypoxia, associated or not with a state of shock, which can be reflected in the Fetal Heart Rate (FHR) by tachycardia or decelerations and result in intrauterine fetal death. The second mechanism is the passage of these pesticides through the placental barrier representing a potential risk to the fetus due to the alteration of the microsomal enzyme systems.
PMID
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Authors

Mayor MeshTerms

Pregnancy Outcome

Keywords

Organophosphorus

acute intoxication

complications

fetus

pregnancy

Journal Title the pan african medical journal
Publication Year Start




PMID- 28293343
OWN - NLM
STAT- MEDLINE
DA  - 20170315
DCOM- 20170329
LR  - 20170330
IS  - 1937-8688 (Electronic)
VI  - 25
DP  - 2016
TI  - [Acute organophosphorus intoxications in pregnant women].
PG  - 227
LID - 10.11604/pamj.2016.25.227.11041 [doi]
AB  - Acute organophosphorus pesticides (OPs) poisoning during pregnancy are rare
      events, not well documented in the literature. We conducted a retrospective
      analysis of outcomes in seven cases of suicidal ingestion of OP in pregnant
      women. This intoxication was most often serious. Indeed, five of seven
      parturients had an initial Glasgow score &lt; 9 and the POP score was &gt;/= 3 in all
      parturients. Five patients required mechanical ventilation for a mean duration of
      3,4 days. All patients reported favorable outcomes but in more than half of the
      cases fetuses had unfavorable outcomes (fetal death in utero). Two mechanisms can
      explain these fetal complications. The first mechanism is fetal hypoxia,
      associated or not with a state of shock, which can be reflected in the Fetal
      Heart Rate (FHR) by tachycardia or decelerations and result in intrauterine fetal
      death. The second mechanism is the passage of these pesticides through the
      placental barrier representing a potential risk to the fetus due to the
      alteration of the microsomal enzyme systems.
FAU - Barhoumi, Mohamed Hafed
AU  - Barhoumi MH
AD  - Service d'Anesthesie et de Reanimation CHU Ibn El Jazzar Kairouan, Tunisie.
FAU - Bannour, Badra
AU  - Bannour B
AD  - Service de Gynecologie et d'Obstetrique CHU Ibn El Jazzar Kairouan, Tunisie.
FAU - Barhoumi, Tarek
AU  - Barhoumi T
AD  - Direction Regionale de la Sante Kairouan, Tunisie.
FAU - Jouini, Rami
AU  - Jouini R
AD  - Service d'Anesthesie et de Reanimation CHU Ibn El Jazzar Kairouan, Tunisie.
FAU - Marwene, Nadia
AU  - Marwene N
AD  - Service de Gynecologie et d'Obstetrique CHU Ibn El Jazzar Kairouan, Tunisie.
FAU - Fatnassi, Mohamed Ridha
AU  - Fatnassi MR
AD  - Service de Gynecologie et d'Obstetrique CHU Ibn El Jazzar Kairouan, Tunisie.
LA  - fre
PT  - Journal Article
TT  - Intoxications aigues aux organophosphores chez la femme enceinte.
DEP - 20161207
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Pesticides)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Female
MH  - Fetal Death/etiology
MH  - Fetal Hypoxia/etiology
MH  - Heart Rate, Fetal
MH  - Humans
MH  - Organophosphate Poisoning/*complications/physiopathology
MH  - Pesticides/*poisoning
MH  - Pregnancy
MH  - Pregnancy Complications/*physiopathology
MH  - *Pregnancy Outcome
MH  - Respiration, Artificial
MH  - Retrospective Studies
MH  - Tachycardia/etiology
MH  - Young Adult
PMC - PMC5337298
OTO - NOTNLM
OT  - *Organophosphorus
OT  - *acute intoxication
OT  - *complications
OT  - *fetus
OT  - *pregnancy
COI - Les auteurs ne declarent aucun conflit d'interet.
EDAT- 2017/03/16 06:00
MHDA- 2017/03/31 06:00
CRDT- 2017/03/16 06:00
PHST- 2016/10/26 [received]
PHST- 2016/11/14 [accepted]
AID - 10.11604/pamj.2016.25.227.11041 [doi]
AID - PAMJ-25-227 [pii]
PST - epublish
SO  - Pan Afr Med J. 2016 Dec 7;25:227. doi: 10.11604/pamj.2016.25.227.11041.
      eCollection 2016.

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