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PMID- 28294085
OWN - NLM
STAT- Publisher
DA  - 20170315
LR  - 20170315
IS  - 1748-5460 (Electronic)
IS  - 0022-2151 (Linking)
DP  - 2017 Mar 15
TI  - Serum cytokine profile of laryngeal squamous cell carcinoma patients.
PG  - 1-7
LID - 10.1017/S0022215117000573 [doi]
AB  - OBJECTIVES: This study aimed to evaluate serum cytokine concentrations in healthy
      individuals and laryngeal squamous cell carcinoma patients. METHODS: A total of
      59 laryngeal squamous cell carcinoma patients and 44 healthy controls were
      included. Multiplex analysis of interleukins 2, 4, 5, 6, 10, 12, 13 and 17 and
      interferon-gamma with respect to the presence of laryngeal carcinoma,
      tumour-node-metastasis T stage, nodal involvement and larynx subsite was
      performed. RESULTS: Statistical analysis revealed no difference in serum cytokine
      levels between patients and healthy controls. The serum interleukin-12
      concentration was significantly higher in patients with early (T1-2) than in
      those with late (T3-4) stage disease and without nodal involvement (p < 0.05).
      Serum interleukin-10 levels were significantly higher in T3-4 stage than in T1-2 
      stage patients (p < 0.05). Additionally, serum interleukin 10, 12 and 13
      concentrations (p < 0.05) and interleukin-6 concentration (p < 0.01) were
      significantly higher in patients with T1-2 stage supraglottic vs glottic tumours.
      CONCLUSION: Serum cytokines level cannot be used as laryngeal squamous cell
      carcinoma markers. Progression from T1-2 to T3-4 stage is followed by decreased
      serum interleukin-12 levels and increased interleukin-10 levels. Nodal
      involvement is associated with lower serum interleukin-12 levels. In patients
      with early stage tumours, serum interleukin 6, 10, 12 and 13 concentrations are
      significantly higher in those with supraglottic vs glottic tumours.
FAU - Sotirovic, J
AU  - Sotirovic J
AD  - Department of Otorhinolaryngology,Military Medical Academy,Belgrade,Serbia.
FAU - Peric, A
AU  - Peric A
AD  - Department of Otorhinolaryngology,Military Medical Academy,Belgrade,Serbia.
FAU - Vojvodic, D
AU  - Vojvodic D
AD  - Institute for Medical Research, Military Medical Academy,Belgrade,Serbia.
FAU - Baletic, N
AU  - Baletic N
AD  - Department of Otorhinolaryngology,Military Medical Academy,Belgrade,Serbia.
FAU - Zaletel, I
AU  - Zaletel I
AD  - Institute of Histology and Embryology 'Aleksandar D Kostic', School of Medicine, 
      University of Belgrade,Belgrade,Serbia.
FAU - Stanojevic, I
AU  - Stanojevic I
AD  - Institute for Medical Research, Military Medical Academy,Belgrade,Serbia.
FAU - Erdoglija, M
AU  - Erdoglija M
AD  - Department of Otorhinolaryngology,Military Medical Academy,Belgrade,Serbia.
FAU - Milojevic, M
AU  - Milojevic M
AD  - Department of Otorhinolaryngology,Military Medical Academy,Belgrade,Serbia.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - England
TA  - J Laryngol Otol
JT  - The Journal of laryngology and otology
JID - 8706896
OTO - NOTNLM
OT  - Squamous Cell
OT  - Carcinoma
OT  - Larynx
OT  - Th1-Th2 Balance
EDAT- 2017/03/16 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/03/16 06:00
AID - S0022215117000573 [pii]
AID - 10.1017/S0022215117000573 [doi]
PST - aheadofprint
SO  - J Laryngol Otol. 2017 Mar 15:1-7. doi: 10.1017/S0022215117000573.

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