PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28314259
OWN - NLM
STAT- MEDLINE
DA  - 20170318
DCOM- 20170411
LR  - 20170411
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 3
DP  - 2017 Mar
TI  - Mast Cells in Mammary Carcinogenesis: Host or Tumor Supporters?
PG  - 1013-1021
AB  - BACKGROUND/AIM: The effects of mast cells on carcinogenesis is not yet fully
      understood. This work aimed to disclose the role of mast cells in mammary
      carcinogenesis in a rat model. MATERIALS AND METHODS: Mammary tumors were induced
      by the administration of N-methyl-N-nitrosourea (MNU) in three groups of rats.
      Animals from one group were treated with ketotifen immediately after MNU
      administration, and animals from another only received ketotifen after the
      development of the first mammary tumor. The biochemical profile was determined.
      Mammary tumors were evaluated by histopathology and immunohistochemistry.
      RESULTS: Animals from ketotifen-treated groups developed fewer mammary tumors,
      higher number of mammary lesions and had lower histamine levels when compared to 
      non-treated animals. Animals treated with ketotifen immediately after MNU
      exhibited the lowest proliferative and apoptotic indexes. CONCLUSION: The mainly 
      positive effect of the inhibition of mast cell degranulation seems to be the
      reduction of tumor proliferation when the mast cell degranulation was inhibited
      before tumor development.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Faustino-Rocha, Ana I
AU  - Faustino-Rocha AI
AD  - Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences,
      University of Tras-os-Montes and Alto Douro, Vila Real, Portugal
      [email protected]
AD  - Center for the Research and Technology of Agro-Environmental and Biological
      Sciences (CITAB), University of Tras-os-Montes and Alto Douro, Vila Real,
      Portugal.
AD  - Animal and Veterinary Research Center (CECAV), School of Agrarian and Veterinary 
      Sciences, University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
AD  - Organic Chemistry, Natural Products and Foodstuffs (QOPNA), Mass Spectrometry
      Center, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
FAU - Gama, Adelina
AU  - Gama A
AD  - Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences,
      University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
AD  - Animal and Veterinary Research Center (CECAV), School of Agrarian and Veterinary 
      Sciences, University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
FAU - Neuparth, Maria J
AU  - Neuparth MJ
AD  - Advanced Polytechnic and University Cooperative (CESPU), Institute of Research
      and Advanced Training in Health Sciences and Technologies (IINFACTS), Gandra,
      Portugal.
AD  - Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of
      Sports, University of Porto, Porto, Portugal.
FAU - Oliveira, Paula A
AU  - Oliveira PA
AD  - Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences,
      University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
AD  - Center for the Research and Technology of Agro-Environmental and Biological
      Sciences (CITAB), University of Tras-os-Montes and Alto Douro, Vila Real,
      Portugal.
FAU - Ferreira, Rita
AU  - Ferreira R
AD  - Organic Chemistry, Natural Products and Foodstuffs (QOPNA), Mass Spectrometry
      Center, Department of Chemistry, University of Aveiro, Aveiro, Portugal.
FAU - Ginja, Mario
AU  - Ginja M
AD  - Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences,
      University of Tras-os-Montes and Alto Douro, Vila Real, Portugal.
AD  - Center for the Research and Technology of Agro-Environmental and Biological
      Sciences (CITAB), University of Tras-os-Montes and Alto Douro, Vila Real,
      Portugal.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 684-93-5 (Methylnitrosourea)
RN  - X49220T18G (Ketotifen)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Cell Transformation, Neoplastic
MH  - Female
MH  - Immunohistochemistry
MH  - Ketotifen/chemistry
MH  - Mammary Neoplasms, Animal/chemically induced/*physiopathology
MH  - Mammary Neoplasms, Experimental/chemically induced/*physiopathology
MH  - Mast Cells/*cytology
MH  - Methylnitrosourea/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - *Degranulation
OT  - *MNU
OT  - *ketotifen
OT  - *mammary tumors
OT  - *mast cells
OT  - *rat
EDAT- 2017/03/21 06:00
MHDA- 2017/04/12 06:00
CRDT- 2017/03/19 06:00
PHST- 2017/01/19 [received]
PHST- 2017/02/25 [revised]
PHST- 2017/02/28 [accepted]
AID - 37/3/1013 [pii]
AID - 10.21873/anticanres.11411 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Mar;37(3):1013-1021.

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