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PMID- 28317362
OWN - NLM
STAT- MEDLINE
DA  - 20170320
DCOM- 20170403
LR  - 20170403
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 34
IP  - 4
DP  - 2016 Aug 01
TI  - [Application of carbon nanoparticles as lymph node tracers in patients with cN0
      lingual squamous cell carcinoma un-dergoing neck dissection].
PG  - 408-413
LID - 10.7518/hxkq.2016.04.018 [doi]
AB  - OBJECTIVE: This study aimed to investigate the value of carbon nanoparticles as
      lymph node tracers in neck dissection for cN0 lingual squamous cell carcinoma
      patients. METHODS: Ninety-six patients with cN0 lingual squamous cell carcinoma
      were recruited to undergo surgical treatment were randomly divided into two
      groups, namely, the carbon nanoparticle-labeled group (the experimental group, 50
      cases) and the control group (46 cases). Carbon nanoparticle suspension was
      injected into the submucosal layer around the site of the primary tumor at three 
      or four points (0.1 mL for each point) 12 h before surgery. Supraomohyoid neck
      dissection (SOHND, Levels to ) or comprehensive neck dissection (CND, Levels to )
      were performed based on the size and location of the primary tumor. All the lymph
      nodes were dissected and separated from the ex vivo surgical specimens for
      histopathological evaluation. The number, size, location, and pathological result
      of all the lymph nodes were compared between the two groups. Statistical analyses
      were conducted by SPSS 19.0 software. RESULTS: A total of 1 137 lymph nodes were 
      detected in 31 SOHND patients. The average number of lymph nodes detected in the 
      experimental group was (43.79+/-19.23) /case, which was significantly higher than
      that in the control group [(30.82+/-8.77) /case] (P=0.019). Level covered the
      largest number of lymph nodes in the two groups. However, the number and
      proportion of lymph nodes found in Level of the experimental group were
      significantly higher than those of the control group (P=0.000). A total of 3 938 
      lymph nodes were detected in 65 CND patients. The average number of lymph nodes
      detected in the experimental group [(66.67+/-20.02) /case] was larger than that
      in the control group [(53.03+/-20.98) /case] (P=0.026). The difference in the
      lymph node location between the two groups was not statistically significant
      (P=0.354). In the two neck dissection methods, both the proportion of minute
      lymph nodes and the accuracy of the detected lymph nodes in the experimental
      group were significantly larger than those in the control groups (P=0.000).
      Compared with the control group, more metastases were proven by the carbon
      nanoparticle-labeled lymph nodes (P=0.000) in the experimental group.
      CONCLUSIONS: Carbon nanoparticles as lymph node tracers in patients with cN0
      lingual squamous cell carcinoma undergoing neck dissection can increase the
      number of detected lymph nodes, especially the minute nodes. Such nanoparticles
      can further ensure the thoroughness of neck dissection and the accuracy of
      clinicopathological stage.
FAU - Tingting, Li
AU  - Tingting L
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
FAU - Canhua, Jiang
AU  - Canhua J
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
FAU - Jie, Chen
AU  - Jie C
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
FAU - Limeng, Wu
AU  - Limeng W
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
FAU - Ruipu, Zhang
AU  - Ruipu Z
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
FAU - Xinchun, Jian
AU  - Xinchun J
AD  - Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South
      University, Changsha 410008, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 7440-44-0 (Carbon)
SB  - D
SB  - IM
MH  - Carbon
MH  - *Carcinoma, Squamous Cell
MH  - Humans
MH  - Lymph Nodes
MH  - Lymphatic Metastasis
MH  - *Nanoparticles
MH  - Neck
MH  - *Neck Dissection
MH  - *Otorhinolaryngologic Neoplasms
MH  - Thyroid Neoplasms
OTO - NOTNLM
OT  - *carbon nanoparticles
OT  - *lingual squamous cell carcinoma
OT  - *lymph node tracers
OT  - *neck dissection
EDAT- 2017/03/21 06:00
MHDA- 2017/04/04 06:00
CRDT- 2017/03/21 06:00
AID - 10.7518/hxkq.2016.04.018 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Aug 1;34(4):408-413. doi:
      10.7518/hxkq.2016.04.018.

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