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Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal Carcinoma.

Abstract The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to correlate with the prognosis of many malignancies. This study evaluated the prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma (NPC). A retrospective analysis of clinical and pathological data of 140 NPC patients without distant metastasis during initial treatment was conducted to identify correlations between NLR, LMR, and PLR and clinicopathological features, overall survival, and progression-free survival. Cox proportional hazard regression analysis was used to reveal the independent factors affecting the prognosis of NPC patients. NLR was associated with T staging, N staging, and overall clinical stage grouping of the NPC patients (P < 0.05). NLR ≥ 2.28, LMR < 2.26, and PLR ≥ 174 were significantly associated with a relatively short overall survival (P < 0.05). In addition, NLR ≥ 2.28 was significantly associated with a relatively short progression-free survival (P < 0.05). Cox proportional hazard regression analysis showed that NLR was an independent prognostic factor in NPC. Pretreatment NLR, LMR, and PLR might be a useful complement to TNM staging in the prognostic assessment of NPC patients.
PMID
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Authors

Mayor MeshTerms

Blood Platelets

Lymphocytes

Monocytes

Nasopharyngeal Neoplasms

Neutrophils

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28321405
OWN - NLM
STAT- MEDLINE
DA  - 20170321
DCOM- 20170322
LR  - 20170322
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte
      Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal
      Carcinoma.
PG  - 3047802
LID - 10.1155/2017/3047802 [doi]
AB  - The peripheral blood neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte
      ratio (LMR), and platelet to lymphocyte ratio (PLR) have been reported to
      correlate with the prognosis of many malignancies. This study evaluated the
      prognostic value of pretreatment NLR, LMR, and PLR in nasopharyngeal carcinoma
      (NPC). A retrospective analysis of clinical and pathological data of 140 NPC
      patients without distant metastasis during initial treatment was conducted to
      identify correlations between NLR, LMR, and PLR and clinicopathological features,
      overall survival, and progression-free survival. Cox proportional hazard
      regression analysis was used to reveal the independent factors affecting the
      prognosis of NPC patients. NLR was associated with T staging, N staging, and
      overall clinical stage grouping of the NPC patients (P &lt; 0.05). NLR &gt;/= 2.28, LMR
      &lt; 2.26, and PLR &gt;/= 174 were significantly associated with a relatively short
      overall survival (P &lt; 0.05). In addition, NLR &gt;/= 2.28 was significantly
      associated with a relatively short progression-free survival (P &lt; 0.05). Cox
      proportional hazard regression analysis showed that NLR was an independent
      prognostic factor in NPC. Pretreatment NLR, LMR, and PLR might be a useful
      complement to TNM staging in the prognostic assessment of NPC patients.
FAU - Lu, Aiying
AU  - Lu A
AD  - Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and
      Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical
      Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
FAU - Li, Haifeng
AU  - Li H
AD  - Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi
      543002, China.
FAU - Zheng, Yuming
AU  - Zheng Y
AD  - Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and
      Molecular Mechanism, Wuzhou, Guangxi 543002, China.
FAU - Tang, Minzhong
AU  - Tang M
AD  - Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and
      Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical
      Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
FAU - Li, Jun
AU  - Li J
AD  - Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and
      Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical
      Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
FAU - Wu, Huihui
AU  - Wu H
AD  - Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi
      543002, China.
FAU - Zhong, Weiming
AU  - Zhong W
AD  - Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi
      543002, China.
FAU - Gao, Jianquan
AU  - Gao J
AD  - Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, Guangxi
      543002, China.
FAU - Ou, Ningjiang
AU  - Ou N
AD  - Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi
      543002, China.
FAU - Cai, Yonglin
AU  - Cai Y
AUID- ORCID: 0000-0002-2001-1351
AD  - Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and
      Molecular Mechanism, Wuzhou, Guangxi 543002, China; Department of Clinical
      Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi 543002, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170222
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - Nasopharyngeal carcinoma
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Blood Platelets
MH  - Child
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Lymphocyte Count
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - *Monocytes
MH  - *Nasopharyngeal Neoplasms/blood/mortality
MH  - *Neutrophils
MH  - Platelet Count
MH  - Survival Rate
PMC - PMC5340935
COI - The authors declare that there is no conflict of interests.
EDAT- 2017/03/23 06:00
MHDA- 2017/03/23 06:01
CRDT- 2017/03/22 06:00
PHST- 2016/06/28 [received]
PHST- 2016/10/03 [accepted]
AID - 10.1155/2017/3047802 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:3047802. doi: 10.1155/2017/3047802. Epub 2017 Feb 22.