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Squared-Off Nuclei and "Appliqué" Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients.

Abstract The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "appliqué" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the appliqué pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the american journal of dermatopathology
Publication Year Start




 
PMID- 28323778
OWN - NLM
STAT- In-Process
DA  - 20170321
LR  - 20170321
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 39
IP  - 4
DP  - 2017 Apr
TI  - Squared-Off Nuclei and "Applique" Pattern as a Histopathological Clue to
      Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 
      46 Patients.
PG  - 275-278
LID - 10.1097/DAD.0000000000000651 [doi]
AB  - The histopathological diagnosis of periocular sebaceous carcinoma can be
      difficult in poorly differentiated cases showing few mature sebocytes. The
      authors examined 50 periocular sebaceous carcinomas from 46 patients to determine
      the frequency of 2 features seen in this neoplasm, namely cells with squared-off 
      nuclei and so-called "applique" pattern (peritumoral subnecrosis of peripherally 
      located neoplastic cells). Neoplastic cells with squared-off nuclei were found in
      varying numbers in both the intraepithelial and dermal (invasive) components in
      all neoplasms, whereas the applique pattern was observed in a third of the cases.
      It is concluded that these features, taken together, may serve as a clue for the 
      diagnosis of periocular sebaceous carcinoma.
FAU - Broekaert, Sigrid M C
AU  - Broekaert SM
AD  - *Department of Dermatology, Venereology and Allergology, University Medical
      Center Gottingen, Gottingen, Germany; daggerDermatohistology and Oral Pathology
      Laboratory, Munich, Germany; double daggerDepartment of Pathology, Faculty of
      Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic; section
      signBioptical Laboratory, Pilsen, Czech Republic; paragraph signDepartment of
      Pathology, University of Texas-MD Anderson Cancer Center, Houston, TX;
      ||Department of Pathology, University Medical Center Gottingen, Gottingen,
      Germany; **Dermatopathology Laboratory, Zurich, Switzerland; and
      daggerdaggerDepartment of Dermatology, University Hospital, Zurich, Switzerland.
FAU - Flux, Katharina
AU  - Flux K
FAU - Kyrpychova, Liubov
AU  - Kyrpychova L
FAU - Kacerovska, Denisa
AU  - Kacerovska D
FAU - Ivan, Doina
AU  - Ivan D
FAU - Schon, Michael P
AU  - Schon MP
FAU - Strobel, Philipp
AU  - Strobel P
FAU - Michal, Michal
AU  - Michal M
FAU - Denisjuk, Natalja
AU  - Denisjuk N
FAU - Kerl, Katrin
AU  - Kerl K
FAU - Kazakov, Dmitry V
AU  - Kazakov DV
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
EDAT- 2017/03/23 06:00
MHDA- 2017/03/23 06:00
CRDT- 2017/03/22 06:00
AID - 10.1097/DAD.0000000000000651 [doi]
AID - 00000372-201704000-00005 [pii]
PST - ppublish
SO  - Am J Dermatopathol. 2017 Apr;39(4):275-278. doi: 10.1097/DAD.0000000000000651.

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