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Research progress on bisphosphonate-related osteonecrosis of the jaws.

Abstract Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is clinically characterized by exposed bones, formation of sequestrum, pain, and halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments for this disease are currently unavailable. Thus, prevention plays an important role in the management of BRONJ. This review summarizes research progress on pathogenesis, risk factors, clinical characteristics, treatment, and prevention of this condition.
PMID
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Authors

Mayor MeshTerms

Bisphosphonate-Associated Osteonecrosis of the Jaw

Keywords

bisphosphonates

jaws

osteonecrosis

Journal Title hua xi kou qiang yi xue za zhi = huaxi kouqiang yixue zazhi = west china journal of stomatology
Publication Year Start




PMID- 28326724
OWN - NLM
STAT- MEDLINE
DA  - 20170322
DCOM- 20170412
LR  - 20170412
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 1
DP  - 2017 Feb 01
TI  - [Research progress on bisphosphonate-related osteonecrosis of the jaws].
PG  - 29-36
LID - 10.7518/hxkq.2017.01.004 [doi]
AB  - Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been
      widely used for treatment of several diseases. In recent years, dentists and oral
      and maxillofacial surgeons reported continuously increasing cases of
      bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is
      clinically characterized by exposed bones, formation of sequestrum, pain, and
      halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments
      for this disease are currently unavailable. Thus, prevention plays an important
      role in the management of BRONJ. This review summarizes research progress on
      pathogenesis, risk factors, clinical characteristics, treatment, and prevention
      of this condition.
FAU - Jian, Pan
AU  - Jian P
AD  - State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery,
      West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
FAU - Qizhang, Wang
AU  - Qizhang W
AD  - State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery,
      West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
FAU - Jiyuan, Liu
AU  - Jiyuan L
AD  - State Key Laboratory of Oral Diseases, Dept. of Oral and Maxillofacial Surgery,
      West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - 0 (Bone Density Conservation Agents)
RN  - 0 (Diphosphonates)
SB  - D
SB  - IM
MH  - *Bisphosphonate-Associated Osteonecrosis of the Jaw
MH  - Bone Density Conservation Agents
MH  - Bone Resorption
MH  - Diphosphonates
MH  - Humans
MH  - Jaw
MH  - Risk Factors
MH  - Treatment Outcome
OAB - Publisher: BPsBRONJBRONJBRONJ.
OABL- eng
OTO - NOTNLM
OT  - *bisphosphonates
OT  - *jaws
OT  - *osteonecrosis
EDAT- 2017/03/23 06:00
MHDA- 2017/04/13 06:00
CRDT- 2017/03/23 06:00
AID - 10.7518/hxkq.2017.01.004 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):29-36. doi:
      10.7518/hxkq.2017.01.004.

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