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PMID- 28326725
OWN - NLM
STAT- MEDLINE
DA  - 20170322
DCOM- 20170412
LR  - 20170412
IS  - 1000-1182 (Print)
IS  - 1000-1182 (Linking)
VI  - 35
IP  - 1
DP  - 2017 Feb 01
TI  - [Analysis of salivary protease spectrum in chronic periodontitis].
PG  - 37-42
LID - 10.7518/hxkq.2017.01.005 [doi]
AB  - OBJECTIVE: This study aimed to investigate the difference in salivary protease
      expression in patients with chronic periodontitis and normal individuals.
      METHODS: The stimulating saliva in patients with chronic periodontitis and normal
      individuals were collected. Protein chip technology was adapted to analyze
      salivary protease spectrum. RESULTS: Among the 34 proteases in the chip,
      disintegrin and metalloproteinase (ADAM)8, matrix metalloproteinase (MMP)-8,
      MMP-12, neprilysin/CD10, and uridylyl phosphate adenosine/urokinase showed a
      significantly increased concentration in the saliva of chronic periodontitis
      patients compared with those in the saliva of normal individuals (P<0.01). By
      contrast, the concentrations of ADAM9, a disintegrin and metalloproteinase with
      thrombospondin motifs (ADAMTS)1, ADAMTS13, cathepsin B, E, L, V, X/Z/P,
      kallikrein 6, 7, 11, 13, MMP-9, proteinase 3, presenilin-1, and proprotein
      convertase 9 sharply decreased (P<0.05). CONCLUSIONS: The results demonstrated
      that protease spectrum in the saliva of chronic periodontitis patients and normal
      individuals significantly differed. Analysis of salivary protease spectrum is a
      potential clinical method to examine, diagnose, and monitor chronic
      periodontitis.
FAU - Qian, Li
AU  - Qian L
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Xuedong, Zhou
AU  - Xuedong Z
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Yaping, Fan
AU  - Yaping F
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Tengyu, Yang
AU  - Tengyu Y
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Songtao, Wu
AU  - Songtao W
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Yu, Yu
AU  - Yu Y
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Jiao, Chen
AU  - Jiao C
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Ping, Zhang
AU  - Ping Z
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
FAU - Yun, Feng
AU  - Yun F
AD  - State Key Laboratory of Oral Diseases, West China Hospital of Stomatology,
      Sichuan University, Chengdu 610041, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Hua Xi Kou Qiang Yi Xue Za Zhi
JT  - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal 
      of stomatology
JID - 9422648
RN  - EC 3.4.24.34 (MMP8 protein, human)
RN  - EC 3.4.24.34 (Matrix Metalloproteinase 8)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - D
SB  - IM
MH  - *Chronic Periodontitis
MH  - Humans
MH  - Matrix Metalloproteinase 8
MH  - Matrix Metalloproteinase 9
MH  - Saliva
OAB - Publisher: ADAM8MMP-8-12/CD10/P<0.01ADAM9ADAMTS113BELVX/Z/P671113MMP-9319P<0.05 .
OABL- eng
OTO - NOTNLM
OT  - *chronic periodontitis
OT  - *protease spectrum
OT  - *saliva
EDAT- 2017/03/23 06:00
MHDA- 2017/04/13 06:00
CRDT- 2017/03/23 06:00
AID - 10.7518/hxkq.2017.01.005 [doi]
PST - ppublish
SO  - Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Feb 1;35(1):37-42. doi:
      10.7518/hxkq.2017.01.005.

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