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Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract: A systematic meta-analysis with PRISMA guidelines.

Abstract The level of p53 protein expression in sinonasal squamous cell carcinoma (SNSCC) has been estimated, but the results remain inconsistent and the point of consensus has not been reached. This study was first determined to evaluate the clinical effects of p53 expression in SCC of the sinonasal tract.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28328848
OWN - NLM
STAT- MEDLINE
DA  - 20170322
DCOM- 20170410
LR  - 20170410
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 12
DP  - 2017 Mar
TI  - Clinical effects of p53 overexpression in squamous cell carcinoma of the
      sinonasal tract: A systematic meta-analysis with PRISMA guidelines.
PG  - e6424
LID - 10.1097/MD.0000000000006424 [doi]
AB  - BACKGROUND: The level of p53 protein expression in sinonasal squamous cell
      carcinoma (SNSCC) has been estimated, but the results remain inconsistent and the
      point of consensus has not been reached. This study was first determined to
      evaluate the clinical effects of p53 expression in SCC of the sinonasal tract.
      METHODS: According to the preferred reporting items for systematic reviews and
      meta-analyses (PRISMA) statement criteria, the potential literature was searched 
      from diverse databases. The pooled odds ratios (ORs) with corresponding 95%
      confidence intervals (CIs) were calculated to assess the strength of association 
      between p53 expression and SNSCC. RESULTS: Final 17 eligible studies were
      included in a total of 258 cases and 748 controls. The result of p53 expression
      was shown to be notably higher in SNSCC than in benign sinonasal papillomas and
      normal sinonasal mucosa (OR = 26.93, P < 0.001; OR = 39.79, P < 0.001;
      respectively). Subgroup analyses of ethnicity revealed that p53 expression had
      significant association with SNSCC in Asian and Caucasian populations in cancer
      versus benign sinonasal papillomas or normal sinonasal mucosa. The expression of 
      p53 was notably higher in moderately or poorly differentiated SNSCC than in
      well-differentiated SNSCC (OR = 3.51, P = 0.021), while p53 expression was not
      associated with histological type. CONCLUSION: The results suggested that p53
      overexpression may be correlated with the carcinogenesis and progression of
      SNSCC. The p53 gene may become a novel drug target of SNSCC. Additional studies
      on the correlation of p53 expression with clinicopathological features are
      needed.
FAU - Wang, Xiaowei
AU  - Wang X
AD  - Department of ENT, Peking Union Medical College Hospital, Peking Union Medical
      College, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Lv, Wei
AU  - Lv W
FAU - Qi, Fang
AU  - Qi F
FAU - Gao, Zhiqiang
AU  - Gao Z
FAU - Yang, Hua
AU  - Yang H
FAU - Wang, Weiqing
AU  - Wang W
FAU - Gao, Yali
AU  - Gao Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - Carcinoma, squamous cell of head and neck
SB  - AIM
SB  - IM
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*pathology
MH  - Head and Neck Neoplasms/*pathology
MH  - Humans
MH  - Odds Ratio
MH  - Paranasal Sinus Neoplasms/*pathology
MH  - Tumor Suppressor Protein p53/*biosynthesis
PMC - PMC5371485
EDAT- 2017/03/23 06:00
MHDA- 2017/04/11 06:00
CRDT- 2017/03/23 06:00
AID - 10.1097/MD.0000000000006424 [doi]
AID - 00005792-201703240-00051 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Mar;96(12):e6424. doi: 10.1097/MD.0000000000006424.

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