PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.

Abstract Background. Dendritic cells could be involved in immune surveillance of highly immunogenic tumors such as melanoma. Their role in the progression melanocytic nevi to melanoma is however a matter of controversy. Methods. The number of dendritic cells within epidermis, in peritumoral zone, and within the lesion was counted on slides immunohistochemically stained for CD1a, CD1c, DC-LAMP, and DC-SIGN in 21 of dysplastic nevi, 27 in situ melanomas, and 21 invasive melanomas. Results. We found a significant difference in the density of intraepidermal CD1c+ cells between the examined lesions; the mean CD1c cell count was 7.00/mm(2) for invasive melanomas, 2.94 for in situ melanomas, and 13.35 for dysplastic nevi. The differences between dysplastic nevi and melanoma in situ as well as between dysplastic nevi and invasive melanoma were significant. There was no correlation in number of positively stained cells between epidermis and dermis. We did not observe any intraepidermal DC-LAMP+ cells neither in melanoma in situ nor in invasive melanoma as well as any intraepidermal DC-SIGN+ cells in dysplastic nevi. Conclusion. It was shown that the number of dendritic cells differs between dysplastic nevi, in situ melanomas, and invasive melanomas. This could eventually suggest their participation in the development of melanoma.
PMID
Related Publications

Cyclin D1 and D3 expression in melanocytic skin lesions.

Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.

Cell cycle analysis can differentiate thin melanomas from dysplastic nevi and reveals accelerated replication in thick melanomas.

IMP-3 EXPRESSION IN BENIGN MELANOCYTIC NEVI, DYSPLASTIC NEVI AND MALIGNANT MELANOMA: PRELIMINARY FINDINGS IN BULGARIAN PATIENTS.

Mast cells in melanocytic skin lesions. An immunohistochemical and quantitative study.

Authors

Mayor MeshTerms
Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28331853
OWN - NLM
STAT- MEDLINE
DA  - 20170323
DCOM- 20170418
LR  - 20170418
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
PG  - 6803756
LID - 10.1155/2017/6803756 [doi]
AB  - Background. Dendritic cells could be involved in immune surveillance of highly
      immunogenic tumors such as melanoma. Their role in the progression melanocytic
      nevi to melanoma is however a matter of controversy. Methods. The number of
      dendritic cells within epidermis, in peritumoral zone, and within the lesion was 
      counted on slides immunohistochemically stained for CD1a, CD1c, DC-LAMP, and
      DC-SIGN in 21 of dysplastic nevi, 27 in situ melanomas, and 21 invasive
      melanomas. Results. We found a significant difference in the density of
      intraepidermal CD1c+ cells between the examined lesions; the mean CD1c cell count
      was 7.00/mm2 for invasive melanomas, 2.94 for in situ melanomas, and 13.35 for
      dysplastic nevi. The differences between dysplastic nevi and melanoma in situ as 
      well as between dysplastic nevi and invasive melanoma were significant. There was
      no correlation in number of positively stained cells between epidermis and
      dermis. We did not observe any intraepidermal DC-LAMP+ cells neither in melanoma 
      in situ nor in invasive melanoma as well as any intraepidermal DC-SIGN+ cells in 
      dysplastic nevi. Conclusion. It was shown that the number of dendritic cells
      differs between dysplastic nevi, in situ melanomas, and invasive melanomas. This 
      could eventually suggest their participation in the development of melanoma.
FAU - Dyduch, Grzegorz
AU  - Dyduch G
AD  - Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical
      College, Grzegorzecka 16, 31-351 Krakow, Poland.
FAU - Tyrak, Katarzyna Ewa
AU  - Tyrak KE
AD  - II Chair of Internal Medicine, Faculty of Medicine, Jagiellonian University
      Medical College, Skawinska 8, 31-066 Krakow, Poland.
FAU - Glajcar, Anna
AU  - Glajcar A
AD  - Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical
      College, Grzegorzecka 16, 31-351 Krakow, Poland.
FAU - Szpor, Joanna
AU  - Szpor J
AD  - Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical
      College, Grzegorzecka 16, 31-351 Krakow, Poland.
FAU - Ulatowska-Bialas, Magdalena
AU  - Ulatowska-Bialas M
AUID- ORCID: 0000-0001-7233-2213
AD  - Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical
      College, Grzegorzecka 16, 31-351 Krakow, Poland.
FAU - Okon, Krzysztof
AU  - Okon K
AUID- ORCID: 0000-0002-1921-5007
AD  - Chair of Pathomorphology, Faculty of Medicine, Jagiellonian University Medical
      College, Grzegorzecka 16, 31-351 Krakow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170226
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1C protein, human)
RN  - 0 (Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD1/*metabolism
MH  - Cell Count
MH  - Child
MH  - Dendritic Cells/*pathology
MH  - Dysplastic Nevus Syndrome/diagnosis/metabolism/*pathology
MH  - Epidermis/metabolism/pathology
MH  - Female
MH  - Glycoproteins/*metabolism
MH  - Humans
MH  - Male
MH  - Melanoma/diagnosis/metabolism/*pathology
MH  - Middle Aged
PMC - PMC5346357
COI - The authors declare that there is no conflict of interests regarding the
      publication of this paper.
EDAT- 2017/03/24 06:00
MHDA- 2017/04/19 06:00
CRDT- 2017/03/24 06:00
PHST- 2016/12/18 [received]
PHST- 2017/01/30 [revised]
PHST- 2017/02/06 [accepted]
AID - 10.1155/2017/6803756 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:6803756. doi: 10.1155/2017/6803756. Epub 2017 Feb 26.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>