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Validity of a New Kit Measuring Salivary Lactate Dehydrogenase Level for Screening Gingivitis.

Abstract Aim. The aim of this study was to determine the usefulness of a new kit that can evaluate salivary lactate dehydrogenase (LD) level in real time for screening gingivitis. Materials and Methods. The study included 70 systemic healthy volunteers [29 males and 41 females; mean age ± SD: 24.1 ± 2.6 years]. Resting saliva was collected from each participant and LD level was evaluated in real time using the kit (a color-changing sheet with an integer scale ranging from 1 to 10). A dentist measured probing pocket depth, clinical attachment level, and the proportion of sites with bleeding on probing (% BOP) at six sites on all teeth. Gingivitis was diagnosed when the BOP value was ≥20%. Results. Salivary LD level was positively correlated with mean % BOP (odds ratio: 1.47, 95% confidence interval: 1.132-1.916, and P < 0.001) in a logistic regression model. The sensitivity and specificity of the kit were 0.89 and 0.98, respectively, at a cut-off value of 8.0 for LD level. Conclusions. The new kit for measurement of salivary LD level may be a useful tool to screen for gingivitis in young adults, which contributes to early detection of future periodontitis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title disease markers
Publication Year Start




PMID- 28337048
OWN - NLM
STAT- MEDLINE
DA  - 20170324
DCOM- 20170420
LR  - 20170420
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 2017
DP  - 2017
TI  - Validity of a New Kit Measuring Salivary Lactate Dehydrogenase Level for
      Screening Gingivitis.
PG  - 9547956
LID - 10.1155/2017/9547956 [doi]
AB  - Aim. The aim of this study was to determine the usefulness of a new kit that can 
      evaluate salivary lactate dehydrogenase (LD) level in real time for screening
      gingivitis. Materials and Methods. The study included 70 systemic healthy
      volunteers [29 males and 41 females; mean age +/- SD: 24.1 +/- 2.6 years].
      Resting saliva was collected from each participant and LD level was evaluated in 
      real time using the kit (a color-changing sheet with an integer scale ranging
      from 1 to 10). A dentist measured probing pocket depth, clinical attachment
      level, and the proportion of sites with bleeding on probing (% BOP) at six sites 
      on all teeth. Gingivitis was diagnosed when the BOP value was &gt;/=20%. Results.
      Salivary LD level was positively correlated with mean % BOP (odds ratio: 1.47,
      95% confidence interval: 1.132-1.916, and P &lt; 0.001) in a logistic regression
      model. The sensitivity and specificity of the kit were 0.89 and 0.98,
      respectively, at a cut-off value of 8.0 for LD level. Conclusions. The new kit
      for measurement of salivary LD level may be a useful tool to screen for
      gingivitis in young adults, which contributes to early detection of future
      periodontitis.
FAU - Ekuni, Daisuke
AU  - Ekuni D
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Yamane-Takeuchi, Mayu
AU  - Yamane-Takeuchi M
AUID- ORCID: 0000-0002-6886-5495
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Kataoka, Kota
AU  - Kataoka K
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Yokoi, Aya
AU  - Yokoi A
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Taniguchi-Tabata, Ayano
AU  - Taniguchi-Tabata A
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Mizuno, Hirofumi
AU  - Mizuno H
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Miyai, Hisataka
AU  - Miyai H
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Uchida, Yoko
AU  - Uchida Y
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Fukuhara, Daiki
AU  - Fukuhara D
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Sugiura, Yoshio
AU  - Sugiura Y
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
FAU - Tomofuji, Takaaki
AU  - Tomofuji T
AUID- ORCID: 0000-0002-7806-3365
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan; Advanced Research Center for Oral and Craniofacial Sciences,
      Okayama University Dental School, Okayama, Japan.
FAU - Morita, Manabu
AU  - Morita M
AD  - Department of Preventive Dentistry, Okayama University Graduate School of
      Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku,
      Okayama, Japan.
LA  - eng
PT  - Evaluation Studies
PT  - Journal Article
DEP - 20170226
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Reagent Kits, Diagnostic)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gingivitis/*diagnosis
MH  - Humans
MH  - L-Lactate Dehydrogenase/*analysis
MH  - Male
MH  - Reagent Kits, Diagnostic/*standards
MH  - Saliva/*chemistry
MH  - Sensitivity and Specificity
PMC - PMC5346391
COI - The authors have no conflict of interests to declare.
EDAT- 2017/03/25 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/03/25 06:00
PHST- 2016/12/14 [received]
PHST- 2017/02/03 [revised]
PHST- 2017/02/07 [accepted]
AID - 10.1155/2017/9547956 [doi]
PST - ppublish
SO  - Dis Markers. 2017;2017:9547956. doi: 10.1155/2017/9547956. Epub 2017 Feb 26.

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