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Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series.

Abstract Glanzmann thrombasthenia is a severe defect of platelet function caused by an inherited deficiency or dysfunction of the glycoprotein IIb/IIIa complex, the platelet fibrinogen receptor. Patients with Glanzmann thrombasthenia experience lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis. Surgery is usually very challenging, requiring close cooperation among surgeons, hematologists, and anesthesiologists. For anatomic reasons, oral surgery is particularly difficult owing to the inherent risk of hemorrhage and the difficulty in achieving local hemostasis. In the present report, we describe 3 successful cases of oral surgery in patients with Glanzmann thrombasthenia and report the surgical and hematologic management of each case.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of oral and maxillofacial surgery : official journal of the american association of oral and maxillofacial surgeons
Publication Year Start




PMID- 28341450
OWN - NLM
STAT- MEDLINE
DA  - 20170325
DCOM- 20170419
LR  - 20170419
IS  - 1531-5053 (Electronic)
IS  - 0278-2391 (Linking)
VI  - 75
IP  - 2
DP  - 2017 Feb
TI  - Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series.
PG  - 256-259
LID - S0278-2391(16)30910-7 [pii]
LID - 10.1016/j.joms.2016.09.048 [doi]
AB  - Glanzmann thrombasthenia is a severe defect of platelet function caused by an
      inherited deficiency or dysfunction of the glycoprotein IIb/IIIa complex, the
      platelet fibrinogen receptor. Patients with Glanzmann thrombasthenia experience
      lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis. Surgery
      is usually very challenging, requiring close cooperation among surgeons,
      hematologists, and anesthesiologists. For anatomic reasons, oral surgery is
      particularly difficult owing to the inherent risk of hemorrhage and the
      difficulty in achieving local hemostasis. In the present report, we describe 3
      successful cases of oral surgery in patients with Glanzmann thrombasthenia and
      report the surgical and hematologic management of each case.
CI  - Copyright (c) 2016 American Association of Oral and Maxillofacial Surgeons.
      Published by Elsevier Inc. All rights reserved.
FAU - Segna, Eleonora
AU  - Segna E
AD  - Resident, Department of Maxillofacial Surgery and Odontostomatology, IRCCS
      Fondazione Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
      Electronic address: [email protected]
FAU - Artoni, Andrea
AU  - Artoni A
AD  - Consultant, Hemophilia and Thrombosis Center, IRCCS Fondazione Ca' Granda
      Ospedale Maggiore Policlinico di Milano, Milano, Italy.
FAU - Sacco, Raffaele
AU  - Sacco R
AD  - Consultant, Department of Maxillofacial Surgery and Odontostomatology, IRCCS
      Fondazione Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
FAU - Gianni, Aldo Bruno
AU  - Gianni AB
AD  - Professor, Department of Maxillofacial Surgery and Odontostomatology, IRCCS
      Fondazione Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20161006
PL  - United States
TA  - J Oral Maxillofac Surg
JT  - Journal of oral and maxillofacial surgery : official journal of the American
      Association of Oral and Maxillofacial Surgeons
JID - 8206428
SB  - AIM
SB  - D
SB  - IM
MH  - Adolescent
MH  - Blood Loss, Surgical/prevention & control
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Oral Surgical Procedures/*adverse effects/methods
MH  - Radicular Cyst/complications/surgery
MH  - Thrombasthenia/*complications
MH  - Tooth Extraction/adverse effects/methods
MH  - Young Adult
EDAT- 2017/03/28 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/03/26 06:00
PHST- 2015/07/03 [received]
PHST- 2016/09/23 [revised]
PHST- 2016/09/26 [accepted]
AID - S0278-2391(16)30910-7 [pii]
AID - 10.1016/j.joms.2016.09.048 [doi]
PST - ppublish
SO  - J Oral Maxillofac Surg. 2017 Feb;75(2):256-259. doi: 10.1016/j.joms.2016.09.048. 
      Epub 2016 Oct 6.

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