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The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer.

Abstract Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.
PMID
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Authors

Mayor MeshTerms
Keywords

Schistosoma haematobium

bladder

estrogen-DNA adduct

estrogen-like metabolites

squamous cell carcinoma

urogenital schistosomiasis

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28345469
OWN - NLM
STAT- MEDLINE
DA  - 20170327
DCOM- 20170407
LR  - 20170407
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 3
DP  - 2017 Mar
TI  - The role of estradiol metabolism in urogenital schistosomiasis-induced bladder
      cancer.
PG  - 1010428317692247
LID - 10.1177/1010428317692247 [doi]
AB  - Urogenital schistosomiasis is a neglected tropical disease that can lead to
      bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains
      unclear, although there is evidence that the human blood fluke Schistosoma
      haematobium, the infectious agent of urogenital schistosomiasis, releases
      estradiol-like metabolites. These kind of compounds have been implicated in other
      cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital 
      schistosomiasis-induced bladder cancer, here we review, interpret, and discuss
      findings of estradiol-like metabolites detected in both the parasite and in the
      human urine during urogenital schistosomiasis. Moreover, we predict pathways and 
      enzymes that are involved in the production of these metabolites emphasizing
      their potential effects on the dysregulation of the tumor suppressor gene p53
      expression during urogenital schistosomiasis. Enhanced understanding of these
      potential carcinogens may not only shed light on urogenital
      schistosomiasis-induced neoplasia of the bladder, but would also facilitate
      development of interventions and biomarkers for this and other
      infection-associated cancers at large.
FAU - Vale, Nuno
AU  - Vale N
AD  - 1 UCIBIO/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences,
      University of Porto, Porto, Portugal.
FAU - Gouveia, Maria J
AU  - Gouveia MJ
AD  - 1 UCIBIO/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences,
      University of Porto, Porto, Portugal.
AD  - 2 Center for the Study of Animal Science, ICETA, University of Porto, Porto,
      Portugal.
FAU - Rinaldi, Gabriel
AU  - Rinaldi G
AD  - 3 Department of Microbiology, Immunology, & Tropical Medicine and Research Center
      for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George
      Washington University, Washington, DC, USA.
AD  - 4 The Wellcome Trust Sanger Institute, Cambridge, UK.
FAU - Santos, Julio
AU  - Santos J
AD  - 5 Clinica da Sagrada Esperanca, Luanda, Angola.
AD  - 6 Experimental Pathology and Therapeutics Group, Research Center of Instituto
      Portugues de Oncologia, Porto, Portugal.
FAU - Santos, Lucio Lara
AU  - Santos LL
AD  - 6 Experimental Pathology and Therapeutics Group, Research Center of Instituto
      Portugues de Oncologia, Porto, Portugal.
FAU - Brindley, Paul J
AU  - Brindley PJ
AD  - 3 Department of Microbiology, Immunology, & Tropical Medicine and Research Center
      for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George
      Washington University, Washington, DC, USA.
FAU - da Costa, Jose M Correia
AU  - da Costa JM
AD  - 2 Center for the Study of Animal Science, ICETA, University of Porto, Porto,
      Portugal.
AD  - 7 Department of Infectious Diseases, R&D Unit, National Health Institute Doutor
      Ricardo Jorge (INSA), Porto, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (DNA Adducts)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Neoplastic/*pathology
MH  - DNA Adducts/genetics
MH  - Estradiol/*metabolism
MH  - Humans
MH  - Reactive Oxygen Species/metabolism
MH  - Schistosoma haematobium/*metabolism
MH  - Schistosomiasis haematobia/*parasitology/*pathology
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Urinary Bladder/pathology
MH  - Urinary Bladder Neoplasms/metabolism/parasitology
OTO - NOTNLM
OT  - *Schistosoma haematobium
OT  - *bladder
OT  - *estrogen-DNA adduct
OT  - *estrogen-like metabolites
OT  - *squamous cell carcinoma
OT  - *urogenital schistosomiasis
EDAT- 2017/03/28 06:00
MHDA- 2017/04/08 06:00
CRDT- 2017/03/28 06:00
AID - 10.1177/1010428317692247 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Mar;39(3):1010428317692247. doi: 10.1177/1010428317692247.

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