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Impact of microRNA dynamics on cancer hallmarks: An oral cancer scenario.

Abstract MicroRNAs are endogenous small noncoding RNAs that negatively regulate gene expression at posttranscriptional level. The discovery of microRNAs has identified a new layer of gene regulation mechanisms, which play a pivotal role in development as well as in various cellular processes, such as proliferation, differentiation, cell growth, and cell death. Deregulated microRNA expression favors acquisition of cancer hallmark traits as well as transforms the tumor microenvironment, leading to tumor development and progression. Many recent studies have revealed altered expression of microRNAs in oral carcinoma with several microRNAs shown to have key biological role in tumorigenesis functioning either as tumor suppressors or as tumor promoters. MicroRNA expression levels correlate with clinicopathological variables and have a diagnostic and prognostic value in oral carcinoma. For these reasons, microRNA has been a hot topic in oral cancer research for the last few years. In this review, we attempt to summarize the present understanding of microRNA deregulation in oral carcinoma, their role in acquiring cancer hallmarks, and their potential diagnostic and prognostic value for oral cancer management.
PMID
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Authors

Mayor MeshTerms
Keywords

MicroRNA

angiogenesis

metastasis

oral cancer

proliferation

tumor microenvironment

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28347239
OWN - NLM
STAT- MEDLINE
DA  - 20170328
DCOM- 20170407
LR  - 20170407
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 3
DP  - 2017 Mar
TI  - Impact of microRNA dynamics on cancer hallmarks: An oral cancer scenario.
PG  - 1010428317695920
LID - 10.1177/1010428317695920 [doi]
AB  - MicroRNAs are endogenous small noncoding RNAs that negatively regulate gene
      expression at posttranscriptional level. The discovery of microRNAs has
      identified a new layer of gene regulation mechanisms, which play a pivotal role
      in development as well as in various cellular processes, such as proliferation,
      differentiation, cell growth, and cell death. Deregulated microRNA expression
      favors acquisition of cancer hallmark traits as well as transforms the tumor
      microenvironment, leading to tumor development and progression. Many recent
      studies have revealed altered expression of microRNAs in oral carcinoma with
      several microRNAs shown to have key biological role in tumorigenesis functioning 
      either as tumor suppressors or as tumor promoters. MicroRNA expression levels
      correlate with clinicopathological variables and have a diagnostic and prognostic
      value in oral carcinoma. For these reasons, microRNA has been a hot topic in oral
      cancer research for the last few years. In this review, we attempt to summarize
      the present understanding of microRNA deregulation in oral carcinoma, their role 
      in acquiring cancer hallmarks, and their potential diagnostic and prognostic
      value for oral cancer management.
FAU - Manasa, V G
AU  - Manasa VG
AD  - Laboratory of Cell Cycle Regulation and Molecular Oncology, Division of Cancer
      Research, Regional Cancer Centre, Thiruvananthapuram, India.
FAU - Kannan, S
AU  - Kannan S
AD  - Laboratory of Cell Cycle Regulation and Molecular Oncology, Division of Cancer
      Research, Regional Cancer Centre, Thiruvananthapuram, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Cell Proliferation/genetics
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Mouth Neoplasms/*genetics/pathology
MH  - Prognosis
MH  - Tumor Microenvironment/genetics
OTO - NOTNLM
OT  - *MicroRNA
OT  - *angiogenesis
OT  - *metastasis
OT  - *oral cancer
OT  - *proliferation
OT  - *tumor microenvironment
EDAT- 2017/03/30 06:00
MHDA- 2017/04/08 06:00
CRDT- 2017/03/29 06:00
AID - 10.1177/1010428317695920 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Mar;39(3):1010428317695920. doi: 10.1177/1010428317695920.

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