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Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia Syndrome.

Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in East Asia with high mortality. Few studies have examined markers that suggest SFTS in febrile patients. To determine useful biochemical markers for SFTS, patients aged 18 years or older with SFTS or microbiologically confirmed community-onset bacteremia with thrombocytopenia (BT) at presentation between June 2013 and December 2015 were included from two tertiary university hospitals in Republic of Korea retrospectively. Eleven patients with SFTS and 62 patients with bacteremia and thrombocytopenia were identified in the study period. Age and sex did not show significant difference among two groups. Fever was more commonly observed but comorbidities were less common in SFTS than in BT (P < 0.05, each). The areas under the curves of serum ferritin, C-reactive protein, white blood cell count, serum procalcitonin, and fibrinogen were above 0.9, indicating the discriminative power of these biomarkers (1.000, 0.991, 0.963, 0.931, and 0.934, resp., all P < 0.05). The optimal cutoff value of serum ferritin was 3,822‚ÄČng/mL in this study. These results suggest that hyperferritinemia is a typical laboratory feature of SFTS, and the serum ferritin level can be used as a marker for clinicians suspecting SFTS.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title disease markers
Publication Year Start




PMID- 28348452
OWN - NLM
STAT- MEDLINE
DA  - 20170328
DCOM- 20170420
LR  - 20170420
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Linking)
VI  - 2017
DP  - 2017
TI  - Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia
      Syndrome.
PG  - 6727184
LID - 10.1155/2017/6727184 [doi]
AB  - Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease
      in East Asia with high mortality. Few studies have examined markers that suggest 
      SFTS in febrile patients. To determine useful biochemical markers for SFTS,
      patients aged 18 years or older with SFTS or microbiologically confirmed
      community-onset bacteremia with thrombocytopenia (BT) at presentation between
      June 2013 and December 2015 were included from two tertiary university hospitals 
      in Republic of Korea retrospectively. Eleven patients with SFTS and 62 patients
      with bacteremia and thrombocytopenia were identified in the study period. Age and
      sex did not show significant difference among two groups. Fever was more commonly
      observed but comorbidities were less common in SFTS than in BT (P &lt; 0.05, each). 
      The areas under the curves of serum ferritin, C-reactive protein, white blood
      cell count, serum procalcitonin, and fibrinogen were above 0.9, indicating the
      discriminative power of these biomarkers (1.000, 0.991, 0.963, 0.931, and 0.934, 
      resp., all P &lt; 0.05). The optimal cutoff value of serum ferritin was 3,822 ng/mL 
      in this study. These results suggest that hyperferritinemia is a typical
      laboratory feature of SFTS, and the serum ferritin level can be used as a marker 
      for clinicians suspecting SFTS.
FAU - Kim, Uh Jin
AU  - Kim UJ
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Oh, Tae Hoon
AU  - Oh TH
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Kim, Bansuk
AU  - Kim B
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Kim, Seong Eun
AU  - Kim SE
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Kang, Seung-Ji
AU  - Kang SJ
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Park, Kyung-Hwa
AU  - Park KH
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Jung, Sook-In
AU  - Jung SI
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
FAU - Jang, Hee-Chang
AU  - Jang HC
AUID- ORCID: 0000-0002-3407-8493
AD  - Department of Infectious Diseases, Chonnam National University Medical School,
      Gwangju, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170228
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-12-9 (Calcitonin)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Calcitonin/blood
MH  - Case-Control Studies
MH  - Female
MH  - Ferritins/*blood
MH  - Fibrinogen/metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phlebotomus Fever/*blood
MH  - Syndrome
MH  - Thrombocytopenia/*blood
PMC - PMC5350410
COI - The authors have declared that no competing interests exist.
EDAT- 2017/03/30 06:00
MHDA- 2017/04/21 06:00
CRDT- 2017/03/29 06:00
PHST- 2016/11/16 [received]
PHST- 2017/02/08 [accepted]
AID - 10.1155/2017/6727184 [doi]
PST - ppublish
SO  - Dis Markers. 2017;2017:6727184. doi: 10.1155/2017/6727184. Epub 2017 Feb 28.

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