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Association of CD40L gene polymorphism with severe Plasmodium falciparum malaria in Indian population.

Abstract Many host genetic factors are associated with the disease severity and fatal outcome of falciparum malaria. CD40L gene has been found to be one of the most important factors associated with malaria in African countries. This study was aimed to investigate the possible association of CD40L gene polymorphism in severe falciparum malaria in Indian adults.
PMID
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Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Keywords
Journal Title journal of vector borne diseases
Publication Year Start




PMID- 28352049
OWN - NLM
STAT- MEDLINE
DA  - 20170329
DCOM- 20170414
LR  - 20170414
IS  - 0972-9062 (Print)
IS  - 0972-9062 (Linking)
VI  - 54
IP  - 1
DP  - 2017 Jan-Mar
TI  - Association of CD40L gene polymorphism with severe Plasmodium falciparum malaria 
      in Indian population.
PG  - 74-79
AB  - BACKGROUND & OBJECTIVES: Many host genetic factors are associated with the
      disease severity and fatal outcome of falciparum malaria. CD40L gene has been
      found to be one of the most important factors associated with malaria in African 
      countries. This study was aimed to investigate the possible association of CD40L 
      gene polymorphism in severe falciparum malaria in Indian adults. METHODS: One
      hundred fifteen adult cases with severe falciparum malaria were included in the
      study. Two single- nucleotide polymorphisms (SNPs) of CD40L gene, CD40L-726(C/T) 
      and CD40L+220(C/T) were investigated, and the possible association with different
      clinical sub-phenotypes of severe falciparum malaria were analyzed. RESULTS:
      Statistically no significant difference was observed in the incidence of
      CD40L-726C between the patients and control group. The incidence of CD40L+220C
      allele was found to be significantly higher (OR, 2.25; p = 0.03) in male patients
      compared to controls but no significant difference was observed in females.
      Haplotype data showed the susceptibility of -726T/+220C haplotype to severe
      malaria whereas -726C/+220T was associated with protection against severe
      malaria. CD40L+220C allele was associated with severe malarial anaemia in males
      (chi2 = 6.60; p = 0.01). INTERPRETATION & CONCLUSION: CD40L gene polymorphism was
      found to be associated with severe falciparum malaria in Indian population
      especially in severe malarial anaemia. CD40L may be considered as a factor of
      immunity in understanding the pathophysiology of falciparum malaria.
FAU - Purohit, Prasanta
AU  - Purohit P
AD  - Sickle Cell Clinic and Molecular Biology Laboratory, Veer Surendra Sai Institute 
      of Medical Sciences and Research (VIMSAR), Sambalpur, India.
FAU - Mohanty, Pradeep Kumar
AU  - Mohanty PK
AD  - Sickle Cell Clinic and Molecular Biology Laboratory; Department of Medicine, Veer
      Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Sambalpur,
      India.
FAU - Patel, Siris
AU  - Patel S
AD  - Sickle Cell Clinic and Molecular Biology Laboratory, Veer Surendra Sai Institute 
      of Medical Sciences and Research (VIMSAR), Sambalpur, India.
FAU - Das, Padmalaya
AU  - Das P
AD  - Department of Infectious Disease, Asian Institute of Public Health, Bhubaneswar, 
      India.
FAU - Das, Kishalaya
AU  - Das K
AD  - Sickle Cell Clinic and Molecular Biology Laboratory, Veer Surendra Sai Institute 
      of Medical Sciences and Research (VIMSAR), Sambalpur, India.
FAU - Panigrahi, Jogeswar
AU  - Panigrahi J
AD  - School of Life Sciences, Sambalpur University, Sambalpur, Odisha, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Vector Borne Dis
JT  - Journal of vector borne diseases
JID - 101212761
RN  - 147205-72-9 (CD40 Ligand)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - CD40 Ligand/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - India
MH  - Malaria, Falciparum/complications/*genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2017/03/30 06:00
MHDA- 2017/04/15 06:00
CRDT- 2017/03/30 06:00
AID - JVectorBorneDis_2017_54_1_74_203187 [pii]
PST - ppublish
SO  - J Vector Borne Dis. 2017 Jan-Mar;54(1):74-79.

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