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Rocuronium-induced neuromuscular block and sugammadex in pediatric patient with duchenne muscular dystrophy: A case Report.

Abstract Anesthetic management of patients with Duchenne muscular dystrophy (DMD) is complicated because these patients are more sensitive to nondepolarizing neuromuscular blocking agents (NMBAs) and are vulnerable to postoperative complications, such as postoperative residual curarization and respiratory failure. Sugammadex is a new reversal agent for aminosteroidal NMBAs, but its safety in children is controversial.
PMID
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Authors

Mayor MeshTerms

Muscular Dystrophy, Duchenne

Keywords
Journal Title medicine
Publication Year Start




PMID- 28353578
OWN - NLM
STAT- MEDLINE
DA  - 20170329
DCOM- 20170407
LR  - 20170407
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 13
DP  - 2017 Mar
TI  - Rocuronium-induced neuromuscular block and sugammadex in pediatric patient with
      duchenne muscular dystrophy: A case Report.
PG  - e6456
LID - 10.1097/MD.0000000000006456 [doi]
AB  - INTRODUCTION: Anesthetic management of patients with Duchenne muscular dystrophy 
      (DMD) is complicated because these patients are more sensitive to nondepolarizing
      neuromuscular blocking agents (NMBAs) and are vulnerable to postoperative
      complications, such as postoperative residual curarization and respiratory
      failure. Sugammadex is a new reversal agent for aminosteroidal NMBAs, but its
      safety in children is controversial. CLINICAL FEATURES: An 11-year-old boy with
      DMD underwent general anesthesia for a percutaneous nephrolithotomy. We used
      rocuronium bromide and sugammadex to reverse the deep neuromuscular block.
      Reversal of neuromuscular block was done 15 minutes after administration of 2
      mg/kg of sugammadex. The patient's recovery from anesthesia was uneventful, and
      he was discharged to the postoperative recovery ward. CONCLUSION: A delayed
      recovery was achieved, but no adverse events were observed, such as
      recurarization or hypersensitivity to sugammadex. We report safe use of 2 mg/kg
      of sugammadex to reverse a deep neuromuscular block in a child with DMD.
FAU - Kim, Ji Eun
AU  - Kim JE
AD  - Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital
      Cheonan, Dongnam-gu, Cheonan, Chungcheongnam-do, Korea.
FAU - Chun, Hea Rim
AU  - Chun HR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Androstanols)
RN  - 0 (Neuromuscular Nondepolarizing Agents)
RN  - 0 (gamma-Cyclodextrins)
RN  - 361LPM2T56 (Sugammadex)
RN  - WRE554RFEZ (rocuronium)
SB  - AIM
SB  - IM
MH  - Androstanols/*antagonists & inhibitors
MH  - Anesthesia, General
MH  - Child
MH  - Humans
MH  - Male
MH  - *Muscular Dystrophy, Duchenne
MH  - Neuromuscular Blockade/*methods
MH  - Neuromuscular Nondepolarizing Agents/*antagonists & inhibitors
MH  - gamma-Cyclodextrins/*pharmacology
EDAT- 2017/03/30 06:00
MHDA- 2017/04/08 06:00
CRDT- 2017/03/30 06:00
AID - 10.1097/MD.0000000000006456 [doi]
AID - 00005792-201703310-00024 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Mar;96(13):e6456. doi: 10.1097/MD.0000000000006456.

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