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Relationship of oestrogen receptor alpha gene polymorphisms with risk for benign prostatic hyperplasia and prostate cancer in Chinese men.

Abstract The relationship of oestrogen receptor with benign prostatic hyperplasia (BPH) and prostate cancer (PC) is not clear at present. This study aimed to investigate the molecular mechanism underlying the occurrence and development of BPH and prostate.Two hundred forty-four PC cases, 260 BPH patients, and 222 healthy men were recruited from Han people in China, and the oestrogen receptor alpha (ESRα) gene polymorphism (rs2234693 [PvuII] and rs9340799 [XbaI]) on intron 1 was determined. The relationship of gene polymorphism with PC and BPH was evaluated with Logistic regression, and the linkage disequilibrium and haplotyping were assessed with SHEsis software.The risk for PC in BPH patients with PvuII C allele was higher (OR = 1.437, 95% CI: 1.110-1.859), but the differentiation degree of cancer cells was relatively better in PC patients with PvuII C allele (OR = 0.419, 95% CI: 0.285-0.616), and most of them are circumscribed (OR = 0.706, 95% CI: 0.485-1.02). There was significant linkage disequilibrium between PvuII and XbaI. The genotype TTAG not only induced BPH (OR = 6.260, 95% CI: 1.407-27.852), but increased the risk for PC (OR = 6.696, 95% CI: 1.504-29.801). However, the genotype TTAG in BPH patients had no relationship with the risk for PC (P > 0.05). Furthermore, men with haplotype TG were more likely to suffer PC (OR = 9.168, 95% CI: 2.393-35.119), but men with haplotype TA and enlarged prostate had a low risk for PC (OR = 0.708, 95% CI: 0.551-0.912).These results show the relationship between ESRα gene polymorphism and susceptibility to PC and BPH in Chinese men, and the ethnic and regional difference as well.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28353585
OWN - NLM
STAT- MEDLINE
DA  - 20170329
DCOM- 20170407
LR  - 20170407
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 13
DP  - 2017 Mar
TI  - Relationship of oestrogen receptor alpha gene polymorphisms with risk for benign 
      prostatic hyperplasia and prostate cancer in Chinese men.
PG  - e6473
LID - 10.1097/MD.0000000000006473 [doi]
AB  - The relationship of oestrogen receptor with benign prostatic hyperplasia (BPH)
      and prostate cancer (PC) is not clear at present. This study aimed to investigate
      the molecular mechanism underlying the occurrence and development of BPH and
      prostate.Two hundred forty-four PC cases, 260 BPH patients, and 222 healthy men
      were recruited from Han people in China, and the oestrogen receptor alpha
      (ESRalpha) gene polymorphism (rs2234693 [PvuII] and rs9340799 [XbaI]) on intron 1
      was determined. The relationship of gene polymorphism with PC and BPH was
      evaluated with Logistic regression, and the linkage disequilibrium and
      haplotyping were assessed with SHEsis software.The risk for PC in BPH patients
      with PvuII C allele was higher (OR = 1.437, 95% CI: 1.110-1.859), but the
      differentiation degree of cancer cells was relatively better in PC patients with 
      PvuII C allele (OR = 0.419, 95% CI: 0.285-0.616), and most of them are
      circumscribed (OR = 0.706, 95% CI: 0.485-1.02). There was significant linkage
      disequilibrium between PvuII and XbaI. The genotype TTAG not only induced BPH (OR
      = 6.260, 95% CI: 1.407-27.852), but increased the risk for PC (OR = 6.696, 95%
      CI: 1.504-29.801). However, the genotype TTAG in BPH patients had no relationship
      with the risk for PC (P > 0.05). Furthermore, men with haplotype TG were more
      likely to suffer PC (OR = 9.168, 95% CI: 2.393-35.119), but men with haplotype TA
      and enlarged prostate had a low risk for PC (OR = 0.708, 95% CI:
      0.551-0.912).These results show the relationship between ESRalpha gene
      polymorphism and susceptibility to PC and BPH in Chinese men, and the ethnic and 
      regional difference as well.
FAU - Han, Zihua
AU  - Han Z
AD  - aLuqiao Division of Affiliated Taizhou Hospital of Wenzhou Medical College
      bCentral Lab of Affiliated Taizhou Hospital of Wenzhou Medical College, Taizhou
      City, Zhejiang Province, China.
FAU - Zhang, Lingzhi
AU  - Zhang L
FAU - Zhu, Rujian
AU  - Zhu R
FAU - Luo, Lifei
AU  - Luo L
FAU - Zhu, Min
AU  - Zhu M
FAU - Fan, Lilong
AU  - Fan L
FAU - Wang, Guanfu
AU  - Wang G
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Estrogen Receptor alpha)
SB  - AIM
SB  - IM
MH  - Adenocarcinoma/*genetics
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian Continental Ancestry Group/genetics
MH  - Case-Control Studies
MH  - China
MH  - Estrogen Receptor alpha/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Prostatic Hyperplasia/*genetics
MH  - Prostatic Neoplasms/*genetics
EDAT- 2017/03/30 06:00
MHDA- 2017/04/08 06:00
CRDT- 2017/03/30 06:00
AID - 10.1097/MD.0000000000006473 [doi]
AID - 00005792-201703310-00031 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Mar;96(13):e6473. doi: 10.1097/MD.0000000000006473.

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