PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Eotaxin and IL-4 levels are increased in induced sputum and correlate with sputum eosinophils in patients with nonasthmatic eosinophilic bronchitis.

Abstract Nonasthmatic eosinophilic bronchitis (NAEB) is characterized by chronic cough and airway eosinophilic inflammation. Airway and systemic inflammation cytokine profile have not been comprehensively described in patients with NAEB.The aim of the study was to identify the cytokine profile in sputum and serum of NAEB patients. Furthermore, the relationship between cytokines and clinical features would be evaluated.Induced sputum and serum were collected from untreated NAEB patients and healthy subjects. The cytokine profile in sputum and serum was analyzed by a bead-based multiplex cytokine assay including 21 cytokines.The levels of EGF, eotaxin, GM-CSF, GRO, IFN-γ, IL-1β, IL-4, IL-6, IL-17A, IP-10, MIP-1α, and TNF-α in sputum were significantly higher in NAEB patients than that in healthy subjects (all P < 0.05). Values of area under the receiver operating characteristic curve (AUROC) of these cytokines were all above 0.750. The concentrations of eotaxin and IL-4 were positively correlated with sputum eosinophil percentage (r = 0.726, P = 0.002; r = 0.511, P = 0.043; respectively). No significant correlations between other cytokines (EGF, GM-CSF, GRO, IFN-γ, IL-1β, IL-6, IL-17A, IP-10, MIP-1α, and TNF-α) in sputum and sputum eosinophil percentage were found. The level of IL-4 in serum was slightly higher in NAEB patients than in healthy subjects. However, there was no correlation between serum IL-4 levels and sputum eosinophil percentage.We identified the cytokine profile in sputum and serum from NAEB patients. Sputum eotaxin and IL-4 could have the potential to become the biomarkers for NAEB and might be useful to assist in the diagnosis of NAEB.
PMID
Related Publications

Increases in airway eosinophilia and a th1 cytokine during the chronic asymptomatic phase of asthma.

Apoptotic eosinophils in sputum from asthmatic patients correlate negatively with levels of IL-5 and eotaxin.

Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis.

Increased S-nitrosothiol levels in nonasthmatic eosinophilic bronchitis compared with cough variant asthma.

Exhaled nitric oxide measurement is useful for the exclusion of nonasthmatic eosinophilic bronchitis in patients with chronic cough.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28353595
OWN - NLM
STAT- MEDLINE
DA  - 20170329
DCOM- 20170406
LR  - 20170413
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 13
DP  - 2017 Mar
TI  - Eotaxin and IL-4 levels are increased in induced sputum and correlate with sputum
      eosinophils in patients with nonasthmatic eosinophilic bronchitis.
PG  - e6492
LID - 10.1097/MD.0000000000006492 [doi]
AB  - Nonasthmatic eosinophilic bronchitis (NAEB) is characterized by chronic cough and
      airway eosinophilic inflammation. Airway and systemic inflammation cytokine
      profile have not been comprehensively described in patients with NAEB.The aim of 
      the study was to identify the cytokine profile in sputum and serum of NAEB
      patients. Furthermore, the relationship between cytokines and clinical features
      would be evaluated.Induced sputum and serum were collected from untreated NAEB
      patients and healthy subjects. The cytokine profile in sputum and serum was
      analyzed by a bead-based multiplex cytokine assay including 21 cytokines.The
      levels of EGF, eotaxin, GM-CSF, GRO, IFN-gamma, IL-1beta, IL-4, IL-6, IL-17A,
      IP-10, MIP-1alpha, and TNF-alpha in sputum were significantly higher in NAEB
      patients than that in healthy subjects (all P &lt; 0.05). Values of area under the
      receiver operating characteristic curve (AUROC) of these cytokines were all above
      0.750. The concentrations of eotaxin and IL-4 were positively correlated with
      sputum eosinophil percentage (r = 0.726, P = 0.002; r = 0.511, P = 0.043;
      respectively). No significant correlations between other cytokines (EGF, GM-CSF, 
      GRO, IFN-gamma, IL-1beta, IL-6, IL-17A, IP-10, MIP-1alpha, and TNF-alpha) in
      sputum and sputum eosinophil percentage were found. The level of IL-4 in serum
      was slightly higher in NAEB patients than in healthy subjects. However, there was
      no correlation between serum IL-4 levels and sputum eosinophil percentage.We
      identified the cytokine profile in sputum and serum from NAEB patients. Sputum
      eotaxin and IL-4 could have the potential to become the biomarkers for NAEB and
      might be useful to assist in the diagnosis of NAEB.
FAU - Zhang, Rui
AU  - Zhang R
AD  - aState Key Laboratory of Respiratory Disease, National Clinical Research Center
      for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First
      Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical
      University, Guangzhou, Guangdong bDepartment of Respiratory and Critical Care
      Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou
      University, Zhengzhou, Henan, China.
FAU - Luo, Wei
AU  - Luo W
FAU - Liang, Zhenyu
AU  - Liang Z
FAU - Tan, Yaxia
AU  - Tan Y
FAU - Chen, Ruchong
AU  - Chen R
FAU - Lu, Wenju
AU  - Lu W
FAU - Zhong, Nanshan
AU  - Zhong N
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Chemokines)
RN  - 0 (IL4 protein, human)
RN  - 207137-56-2 (Interleukin-4)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Breath Tests
MH  - Bronchitis/immunology/*metabolism
MH  - Case-Control Studies
MH  - Chemokines/*metabolism
MH  - Cross-Sectional Studies
MH  - Eosinophilia/immunology/*metabolism
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoglobulin E
MH  - Interleukin-4/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/metabolism
MH  - Sputum/immunology/*metabolism
MH  - Young Adult
PMC - PMC5380279
EDAT- 2017/03/30 06:00
MHDA- 2017/04/07 06:00
CRDT- 2017/03/30 06:00
AID - 10.1097/MD.0000000000006492 [doi]
AID - 00005792-201703310-00041 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Mar;96(13):e6492. doi: 10.1097/MD.0000000000006492.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>