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Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland.

Abstract Newborns are a population in which antibiotic consumption is extremely high. Targeted antibiotic therapy should help to reduce antibiotics consumption. The aim of this study was an assessment of antibiotic usage in bloodstream infections treatment in the Polish Neonatology Surveillance Network (PNSN) and determining the possibility of applying this kind of data in infection control, especially for the evaluation of standard methods of microbiological diagnostics.
PMID
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Authors

Mayor MeshTerms

Drug Utilization

Infant, Very Low Birth Weight

Keywords

Antimicrobial consumption

Bloodstream infections

Infection surveillance

Neonatal infections

Journal Title annals of clinical microbiology and antimicrobials
Publication Year Start




PMID- 28359268
OWN - NLM
STAT- MEDLINE
DA  - 20170331
DCOM- 20170417
LR  - 20170417
IS  - 1476-0711 (Electronic)
IS  - 1476-0711 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Mar 31
TI  - Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream
      infections among very low birth weight neonates in Poland.
PG  - 20
LID - 10.1186/s12941-017-0196-y [doi]
AB  - BACKGROUND: Newborns are a population in which antibiotic consumption is
      extremely high. Targeted antibiotic therapy should help to reduce antibiotics
      consumption. The aim of this study was an assessment of antibiotic usage in
      bloodstream infections treatment in the Polish Neonatology Surveillance Network
      (PNSN) and determining the possibility of applying this kind of data in infection
      control, especially for the evaluation of standard methods of microbiological
      diagnostics. METHODS: Data were collected between 01.01.2009 and 31.12.2013 in
      five teaching NICUs from the PNSN. The duration of treatment in days (DOT) and
      the defined daily doses (DDD) were used for the assessment of antibiotics
      consumption. RESULTS: The median DOT for a single case of BSI amounted to 8.0
      days; whereas the median consumption expressed in DDD was 0.130. In the case of
      laboratory confirmed BSI, median DOT was 8 days, and consumption-0.120 DDD.
      Median length of therapy was shorter for unconfirmed cases: 7 days, while the
      consumption of antibiotics was higher-0.140 DDD (p < 0.0001). High consumption of
      glycopeptides expressed in DOTs was observed in studied population, taking into
      account etiology of infection. CONCLUSIONS: Even application of classical methods
      of microbiological diagnostics significantly reduces the consumption of
      antibiotics expressed by DDD. However, the high consumption of glycopeptides
      indicates the necessity of applying rapid diagnostic assays. Nevertheless, the
      assessment of antibiotic consumption in neonatal units represents a
      methodological challenge and requires the use of different measurement tools.
FAU - Rozanska, A
AU  - Rozanska A
AD  - Chair of Microbiology, Jagiellonian University Medical College, 18 Czysta Street,
      31-121, Krakow, Poland. [email protected]
FAU - Wojkowska-Mach, J
AU  - Wojkowska-Mach J
AD  - Chair of Microbiology, Jagiellonian University Medical College, 18 Czysta Street,
      31-121, Krakow, Poland.
FAU - Adamski, P
AU  - Adamski P
AD  - Institute of Nature Conservation Polish Academy of Sciences, Krakow, Poland.
FAU - Borszewska-Kornacka, M
AU  - Borszewska-Kornacka M
AD  - Clinic of Neonatology and Intensive Neonatal Care, Warsaw Medical University,
      Warsaw, Poland.
FAU - Gulczynska, E
AU  - Gulczynska E
AD  - Clinic of Neonatology, Polish Mother's Memorial Hospital-Research Institute,
      Lodz, Poland.
FAU - Nowiczewski, M
AU  - Nowiczewski M
AD  - Clinic of Neonatology, Polish Mother's Memorial Hospital-Research Institute,
      Lodz, Poland.
FAU - Helwich, E
AU  - Helwich E
AD  - Clinic of Neonatology and Intensive Neonatal Care, Institute of Mother and Child,
      Warsaw, Poland.
FAU - Kordek, A
AU  - Kordek A
AD  - Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland.
FAU - Pawlik, D
AU  - Pawlik D
AD  - Clinic of Neonatology, Jagiellonian University Medical College, Krakow, Poland.
FAU - Bulanda, M
AU  - Bulanda M
AD  - Chair of Microbiology, Jagiellonian University Medical College, 18 Czysta Street,
      31-121, Krakow, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170331
PL  - England
TA  - Ann Clin Microbiol Antimicrob
JT  - Annals of clinical microbiology and antimicrobials
JID - 101152152
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - *Drug Utilization
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Very Low Birth Weight
MH  - Neonatal Sepsis/*diagnosis/*drug therapy
MH  - Poland
PMC - PMC5374675
OTO - NOTNLM
OT  - Antimicrobial consumption
OT  - Bloodstream infections
OT  - Infection surveillance
OT  - Neonatal infections
EDAT- 2017/04/01 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/01 06:00
PHST- 2016/03/05 [received]
PHST- 2017/03/23 [accepted]
AID - 10.1186/s12941-017-0196-y [doi]
AID - 10.1186/s12941-017-0196-y [pii]
PST - epublish
SO  - Ann Clin Microbiol Antimicrob. 2017 Mar 31;16(1):20. doi:
      10.1186/s12941-017-0196-y.

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