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Electroacupuncture for tapering off long-term benzodiazepine use: study protocol of randomized controlled trial.

Abstract Conventional approaches for benzodiazepine tapering have their limitations. Anecdotal studies have shown that acupuncture is a potential treatment for facilitating successful benzodiazepine tapering. As of today, there was no randomized controlled trial examining its efficacy and safety. The purpose of the study is to evaluate the efficacy of using electroacupuncture as an adjunct treatment to gradual tapering of benzodiazepine doses in complete benzodiazepine cessation in long-term benzodiazepine users.
PMID
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Authors

Mayor MeshTerms

Electroacupuncture

Keywords

Acupuncture

Benzodiazepine discontinuation

RCT

Sham

Withdrawal

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28359309
OWN - NLM
STAT- MEDLINE
DA  - 20170331
DCOM- 20170417
LR  - 20170417
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Mar 31
TI  - Electroacupuncture for tapering off long-term benzodiazepine use: study protocol 
      of randomized controlled trial.
PG  - 183
LID - 10.1186/s12906-017-1692-5 [doi]
AB  - BACKGROUND: Conventional approaches for benzodiazepine tapering have their
      limitations. Anecdotal studies have shown that acupuncture is a potential
      treatment for facilitating successful benzodiazepine tapering. As of today, there
      was no randomized controlled trial examining its efficacy and safety. The purpose
      of the study is to evaluate the efficacy of using electroacupuncture as an
      adjunct treatment to gradual tapering of benzodiazepine doses in complete
      benzodiazepine cessation in long-term benzodiazepine users. METHODS/DESIGN: The
      study protocol of a randomized, assessor- and subject-blinded, controlled trial
      is presented. One hundred and forty-four patients with histories of using
      benzodiazepines in >/=50% of days for more than 3 months will be randomly
      assigned in a 1:1 ratio to receive either electroacupuncture or placebo
      electroacupuncture combined with gradual benzodiazepine tapering schedule. Both
      experimental and placebo treatments will be delivered twice per week for 4 weeks.
      Major assessments will be conducted at baseline, week 6 and week 16
      post-randomization. Primary outcome is the cessation rate of benzodiazepine use. 
      Secondary outcomes include the percentage change in the doses of benzodiazepine
      usage and the severity of withdrawal symptoms experienced based on the
      Benzodiazepine Withdrawal Symptom Questionnaire, insomnia as measured by the
      Insomnia Severity Index, and anxiety and depressive symptoms as evaluated by the 
      Hospital Anxiety and Depression Scale. Adverse events will also be measured at
      each study visit. DISCUSSION: Results of this study will provide high quality
      evidence of the efficacy and safety of electroacupuncture as an adjunct treatment
      for benzodiazepine tapering in long-term users. TRIAL REGISTRATION:
      ClinicalTrials.gov NCT02475538 .
FAU - Yeung, Wing-Fai
AU  - Yeung WF
AD  - The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong SAR, China.
FAU - Chung, Ka-Fai
AU  - Chung KF
AD  - Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong SAR,
      China. [email protected]
FAU - Zhang, Zhang-Jin
AU  - Zhang ZJ
AD  - School of Chinese Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR,
      China.
FAU - Chan, Wai-Chi
AU  - Chan WC
AD  - Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong SAR,
      China.
FAU - Zhang, Shi-Ping
AU  - Zhang SP
AD  - School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, 
      Hong Kong SAR, China.
FAU - Ng, Roger Man-Kin
AU  - Ng RM
AD  - Department of Psychiatry, Kowloon Hospital, 147A Argyle Street, Kowloon, Hong
      Kong SAR, China.
FAU - Chan, Connie Lai-Wah
AU  - Chan CL
AD  - Department of Psychiatry, United Christian Hospital, 130 Hip Wo Street, Kwun
      Tong, Kowloon, Hong Kong SAR, China.
FAU - Ho, Lai-Ming
AU  - Ho LM
AD  - School of Public Health, University of Hong Kong, Pokfulam, Hong Kong SAR, China.
FAU - Yu, Yee-Man
AU  - Yu YM
AD  - The Hong Kong Polytechnic University, Hunghom, Kowloon, Hong Kong SAR, China.
FAU - Lao, Li-Xing
AU  - Lao LX
AD  - School of Chinese Medicine, University of Hong Kong, Pokfulam, Hong Kong SAR,
      China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170331
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 12794-10-4 (Benzodiazepines)
SB  - IM
MH  - Adult
MH  - Anxiety/*drug therapy
MH  - Benzodiazepines/administration & dosage/*adverse effects
MH  - Clinical Protocols
MH  - *Electroacupuncture
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sleep Initiation and Maintenance Disorders/*drug therapy
MH  - Substance Withdrawal Syndrome/etiology/*therapy
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
PMC - PMC5374579
OTO - NOTNLM
OT  - *Acupuncture
OT  - *Benzodiazepine discontinuation
OT  - *RCT
OT  - *Sham
OT  - *Withdrawal
EDAT- 2017/04/01 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/04/01 06:00
PHST- 2016/12/15 [received]
PHST- 2017/03/16 [accepted]
AID - 10.1186/s12906-017-1692-5 [doi]
AID - 10.1186/s12906-017-1692-5 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Mar 31;17(1):183. doi: 10.1186/s12906-017-1692-5.

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